- "Physiological spaces and multicompartmental pharmacokinetic models": Fundamentals that pharmacokinetics textbooks do not tell you
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Yim DS
- KMID: 2351804
- Transl Clin Pharmacol.
- 2015 Dec;23(2):35-37.
- doi: 10.12793/tcp.2015.23.2.35
No abstract available. -
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- Clearance
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Holford N, Yim DS
- KMID: 2351806
- Transl Clin Pharmacol.
- 2015 Dec;23(2):42-45.
- doi: 10.12793/tcp.2015.23.2.42
This tutorial deals with basic concepts of clearance, the most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration and elimination rate... -
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- Physiological spaces and multicompartmental pharmacokinetic models
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Atkinson A
- KMID: 2351805
- Transl Clin Pharmacol.
- 2015 Dec;23(2):38-41.
- doi: 10.12793/tcp.2015.23.2.38
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic... -
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- Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers
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Lee J, Kim A, Yu KS, Chung JY, Yim SV, Kim BH
- KMID: 2351808
- Transl Clin Pharmacol.
- 2015 Dec;23(2):49-53.
- doi: 10.12793/tcp.2015.23.2.49
Olmesartan is an angiotensin receptor blocker (ARB) and is widely used in clinical practice to treat hypertension. To compare the pharmacokinetic (PK) parameters and tolerability of two oral formulations of... -
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- Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425
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Shin YG, Meijering , van Heuveln FH, Wieling J, Halladay J, Sahasranaman S, Hop CE
- KMID: 2351810
- Transl Clin Pharmacol.
- 2015 Dec;23(2):59-65.
- doi: 10.12793/tcp.2015.23.2.59
The development and validation of a method for the determination of concentrations of thiocyanate in human plasma are described here. A modified colorimetric method of Bowler was used with the... -
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- A quantitative approach for cardiovascular safety evaluation of a generic drug
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Son M, Kim Y, Chae DW, Park K
- KMID: 2351809
- Transl Clin Pharmacol.
- 2015 Dec;23(2):54-58.
- doi: 10.12793/tcp.2015.23.2.54
In generic drug development, comparative pharmacokinetic (PK) studies are conducted to assess equivalence in pharmacokinetics and safety profiles between test and reference formulations. However, there is no established quantitative approach... -
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- Population pharmacokinetic analysis of the multiple peaks phenomenon in sumatriptan
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Lee J, Lim MS, Seong SJ, Park SM, Gwon MR, Han S, Lee SM, Kim W, Yoon YR, Yoo HD
- KMID: 2351811
- Transl Clin Pharmacol.
- 2015 Dec;23(2):66-74.
- doi: 10.12793/tcp.2015.23.2.66
The objective of this study was to develop a population pharmacokinetic (PK) model for sumatriptan, which frequently shows an atypical absorption profile with multiple peaks. Sumatriptan, a selective agonist for... -
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- Serious adverse events during clinical trial for pharmacokinetic interaction between telmisartan and chlorthalidone in healthy Korean subjects: A case report
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Seong SJ, Yoon YR, Lim MS
- KMID: 2351807
- Transl Clin Pharmacol.
- 2015 Dec;23(2):46-48.
- doi: 10.12793/tcp.2015.23.2.46
Telmisartan is an angiotensin II receptor antagonist and chlorthalidone is a thiazide-like diuretics. In this study, we report serious adverse events (SAEs) during clinical trial for pharmacokinetic interaction between telmisartan... -
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