Transl Clin Pharmacol.  2015 Dec;23(2):35-37. 10.12793/tcp.2015.23.2.35.

"Physiological spaces and multicompartmental pharmacokinetic models": Fundamentals that pharmacokinetics textbooks do not tell you

• Yim DS

• KMID: 2351804
• DOI: http://doi.org/10.12793/tcp.2015.23.2.35

Abstract

No abstract available.

MeSH Terms

Pharmacokinetics*

Figure

• 

  Figure 1. Key historical figures who contributed to the permeability-flow equation (Renkin equation).

Reference

References

1. Atkinson AJ Jr. Physiological spaces and multicompartmental pharmacokinetic models. Transl Clin Pharmacol. 2015; 23:35–37.

2. Paalzow LK. Torsten Teorell, the father of pharmacokinetics. Uppsala J Med Sci. 1995; 100:41–46.

3. Bowsher DJ, Avram MJ, Frederiksen MC, Asada A, Atkinson AJ Jr. Urea distribution kinetics analyzed by the simultaneous injection of urea and inulin: Demonstration that transcapillary exchange is rate limiting. J Pharmacol ExpTher. 1984; 230:269–274.

4. Bohr C. Über die spezifische Tätigkeit der Lungenbei der respiratorischen Gasaufnahme und ihr Verhaltenzu der durch die Alveolarwandstattfinden-den Gasdiffusion. Skand Arch Physiol. 1909; 22:221–280.

5. West JB. A Century of Pulmonary Gas Exchange. Am J Respir Crit Care Med. 2004; 169:897–902.

6. Kety S. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951; 3:1–41.

7. Elsenberg L. Obituary: Seymour S. Kety (1915–2000). Nature. 2000; 406:472.

8. Renkin EM. Effects of blood flow on diffusion kinetics in isolated perfused hindlegs of cats: a double circulation hypothesis. Am J Physiol. 1955; 183:125–136.

9. Stec GP, Atkinson AJ Jr. Analysis of the contributions of permeability and flow to intercompartmental clearance. J Pharmacokinet Biopharm. 1981; 9:167–180.

10. Sedek GS, Ruo TI, Frederiksen MC, Frederiksen JW, Shih S-R, Atkinson AJ Jr. Splanchnic tissues are a major part of the rapid distribution spaces of inulin, urea and theophylline. J Pharmacol Exp Ther. 1989; 251:1026–1031.

11. Bowsher DJ, Krejcie TC, Avram MJ, Chow MJ, Del Greco F, Atkinson AJ Jr. Reduction in slow intercompartmental clearance of urea during dialysis. J Lab Clin Med. 1985; 105:489–497.