- Dual Expression of Two Transgenes Introduced by Lentiviral Vectors
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Park SJ, Choi SJ, Park JY, Lee KH
- KMID: 1574120
- J Bacteriol Virol.
- 2005 Jun;35(2):157-164.
Lentiviruses can infect mitotic and non-dividing cells owing to the karyophilic properties of their pre-integrating complex, which allow its active import through the nucleopore. Thus lentiviral vectors derived from human... -
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- Chemicals as the Sole Transformers of Cell Fate
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Ebrahimi B
- KMID: 2164156
- Int J Stem Cells.
- 2016 May;9(1):9-20.
- doi: 10.15283/ijsc.2016.9.1.9
Forced expression of lineage-specific transcription factors in somatic cells can result in the generation of different cell types in a process named direct reprogramming, bypassing the pluripotent state. However, the... -
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- Evaluation of recombinant adenovirus-mediated gene delivery for expression of tracer genes in catecholaminergic neurons
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Kim ML, Han S, Lee SB, Kim JH, Ahn HK, Huh Y
- KMID: 2168889
- Anat Cell Biol.
- 2010 Jun;43(2):157-164.
- doi: 10.5115/acb.2010.43.2.157
Selective labeling of small populations of neurons of a given phenotype for conventional neuronal tracing is difficult because tracers can be taken up by all neurons at the injection site,... -
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- Molecular Nuclear Cardiac Imaging
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Lee DS, Paeng JC
- KMID: 2078810
- Korean J Nucl Med.
- 2004 Apr;38(2):175-179.
Molecular nuclear cardiac imaging has included Tc-99m Annexin imaging to visualize myocardial apoptosis, but is now usually associated with gene therapy and cell-based therapy. Cardiac gene therapy was not successful... -
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- An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions
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Lee JE, Han PL
- KMID: 1427106
- Exp Neurobiol.
- 2013 Jun;22(2):84-95.
- doi: 10.5607/en.2013.22.2.84
Animal models of Alzheimer disease (AD) are used to study the mechanisms underlying AD pathogenesis, genetic interactions with genes of interest, and environmental risk factors that cause sporadic AD as... -
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- Enhancement of Adenoviral Transduction and Immunogenecity of Transgenes by Soluble Coxsackie and Adenovirus Receptor-TAT Fusion Protein on Dendritic Cells
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Kim HS, Park MY, Park JS, Kim CH, Kim SG, Oh ST, Kim TG
- KMID: 1513151
- Immune Netw.
- 2006 Dec;6(4):192-198.
- doi: 10.4110/in.2006.6.4.192
BACKGROUND: Investigating strategy to enhance efficiency of gene transfer via adenovirus is critical to sustain gene expression in targeted cells or tissues to regulate immune responses. However, the use of... -
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- Development of Dual Reporter System of Mutant Dopamine 2 Receptor (D2R) and Sodium Iodide Symporter (NIS) Transgenes
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Hwang DW, Lee DS, Kang JH, Chang YS, Kim YH, Jeong JM, Chung JK, Lee MC
- KMID: 1990860
- Korean J Nucl Med.
- 2004 Aug;38(4):294-299.
PURPOSE: Both human NIS and mutant D2R transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide... -
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- Production of transgenic pigs using a pGFAP-CreER(T2)/EGFP(LoxP) inducible system for central nervous system disease models
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Hwang SU, Eun K, Yoon JD, Kim H, Hyun SH
- KMID: 2412134
- J Vet Sci.
- 2018 May;19(3):434-445.
- doi: 10.4142/jvs.2018.19.3.434
Transgenic (TG) pigs are important in biomedical research and are used in disease modeling, pharmaceutical toxicity testing, and regenerative medicine. In this study, we constructed two vector systems by using... -
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- Selective expression of death receptor 4 and induction of apoptosis by HPV E6
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Choi E, Koh H, Shin S, Kim K
- KMID: 2244946
- Korean J Gynecol Oncol Colposc.
- 2002 Jun;13(2):139-145.
Human papillomaviruses, especially type 16 and 18, have been known to be closely associated with human cervix cancer. The E6 and E7 proteins encoded by these viruses disrupt normal cell... -
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- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
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Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
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- Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice
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Wang AG, Moon HB, Lee YH, Yu SL, Kwon HJ, Han YH, Fang W, Lee TH, Jang KL, Kim SK, Yu DY, Lee DS
- KMID: 1103328
- Exp Mol Med.
- 2004 Dec;36(6):588-592.
Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are... -
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- Combination Gene Therapy Using IL-2 and GM-CSF Genes Transferred by a Defective Infectious Single Cycle Herpes Virus (DISC Virus) in Head and Neck Squamous Cell Cancer Model
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Kim SH, Hong WP, Choi EC, Yoon JH, Choi JJ, Yoon HC
- KMID: 2275629
- Korean J Otolaryngol-Head Neck Surg.
- 2001 Jan;44(1):71-79.
BACKGROUND AND OBJECTIVES: The Herpes Simplex type 2 Defective Infectious Single Cycle virus (DISC virus) is an attenuated virus originally produced as a viral vaccine, but it also serves as... -
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- Cardiac expression profiles of the naked DNA vectors encoding vascular endothelial growth factor and basic fibroblast growth factor
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Lee JS, Byun J, Kim JM, Kim CY, Kim BM, Chung JH, Jang Y, Kim DK
- KMID: 1089454
- Exp Mol Med.
- 2005 Oct;37(5):447-456.
We investigated expression profiles and biological effects of the naked DNA vectors in the heart. To this end, naked DNA vector was injected into the apex of the beating rat... -
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- Animal Models of Cancer in the Head and Neck Region
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Kim S
- KMID: 2007185
- Clin Exp Otorhinolaryngol.
- 2009 Jun;2(2):55-60.
- doi: 10.3342/ceo.2009.2.2.55
Animal models that resemble the cancers of the head and neck region are of paramount importance in studying the carcinogenesis of these diseases. Although several methods for modeling cancer in... -
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- Inducible Mouse Models for Cancer Drug Target Validation
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Jeong JH
- KMID: 2367561
- J Cancer Prev.
- 2016 Dec;21(4):243-248.
- doi: 10.15430/JCP.2016.21.4.243
Genetically-engineered mouse (GEM) models have provided significant contributions to our understanding of cancer biology and developing anticancer therapeutic strategies. The development of GEM models that faithfully recapitulate histopathological and clinical... -
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- The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein
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Park E, Choi Y, Ahn E, Park I, Yun Y
- KMID: 1009394
- Exp Mol Med.
- 2009 Oct;41(10):728-736.
- doi: 10.3858/emm.2009.41.10.079
The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified... -
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- Enhancement of Transduction Efficiency and Antitumor Effects of IL-12N220L-expressing Adenovirus by Co-delivery of DOTAP
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Youn JI, Jin HT, Sung YC
- KMID: 2150635
- Immune Netw.
- 2007 Dec;7(4):179-185.
- doi: 10.4110/in.2007.7.4.179
BACKGROUND: Adenovirus (Ad) vectors have been widely used for many gene therapy applications because of their high transduction ability and broad tropism. However, their utility for cancer gene therapy is... -
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- Probing the Utility of Vascular Smooth Muscle Cells as a Target Cell for ex vivo Cardiovascular Gene Therapy
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Byun J, Huh JE, Jung EA, Park SJ, Jeong JO, Gwon HC, Park SW, Kim DK
- KMID: 2227358
- Korean Circ J.
- 2000 Jun;30(6):729-736.
- doi: 10.4070/kcj.2000.30.6.729
BACKGROUND AND OBJECTIVES: Compared to other target cells examined for gene therapy, vascular smooth muscle cells (VSMCs) have the unique advantages including proximity to blood stream and relative abundance in... -
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- Host Immune Responses to Intradiscal Gene Transfer
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Moon SH, Kim H, Kwon EH, Park EH, Lee HM, Hahn SB, Kim NH, Gilbertson LG, Kang JD
- KMID: 2322876
- J Korean Soc Spine Surg.
- 2002 Jun;9(2):84-90.
PURPOSE: To elucidate host immune responses to intradiscal gene transfer. MATERIALS AND METHODS: Twenty rabbits were utilized. Ad/luciferase (adenovirus construct) were injected into nucleus pulposus of lumbar vertebrae. Group 1 received... -
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- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
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Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N
- KMID: 994399
- Exp Mol Med.
- 2010 Nov;42(11):759-767.
- doi: 10.3858/emm.2010.42.11.077
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how... -
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