- Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers
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Park SR
- KMID: 2150754
- Immune Netw.
- 2012 Dec;12(6):230-239.
- doi: 10.4110/in.2012.12.6.230
Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination and somatic hypermutation for... -
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- The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
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Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG
- KMID: 756078
- Exp Mol Med.
- 2007 Aug;39(4):544-555.
We have investigated the function and mechanisms of the CARM1-SNF5 complex in T3-dependent transcriptional activation. Using specific small interfering RNAs (siRNA) to knock down coactivators in HeLa alpha2 cells, we... -
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- Role of PI3K/Akt Pathway in the Activation of IkappaB/NF-kappaB Pathway in Lung Epithelial Cells
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Lee SM, Kim YK, Hwang YH, Lee CH, Lee HS, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG
- KMID: 2158847
- Tuberc Respir Dis.
- 2003 May;54(5):551-562.
- doi: 10.4046/trd.2003.54.5.551
BACKGROUND: NF-kappaB is a characteristic transcriptional factor which has been shown to regulate production of acute inflammatory mediators and to be involved in the pathogenesis of many inflammatory lung diseases.... -
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- Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes
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Choi EH, Kim HS, Chanock SJ, Lee HJ
- KMID: 2278622
- Korean J Pediatr.
- 2005 May;48(5):495-499.
PURPOSE: Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in... -
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- Signaling Pathway of the Bacterial Lipopolysaccharide-induced Generation of Nitric Oxide in Rat Primary Astorcytes
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Kwang S, Park RK, Lee SY, Park MC
- KMID: 2340348
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):881-893.
OBJECTIVES: Nitric oxide(NO)plays an important role in pathophysiology of stroke and various neurodegenerative diseases. This study is designed to elucidate the mechanisms by which signaling pathway of LPS-stimulated NO... -
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- Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells
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Park GH, Song HM, Jeong JB
- KMID: 2378813
- Biomol Ther.
- 2017 May;25(3):337-343.
- doi: 10.4062/biomolther.2016.114
Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic... -
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- Triptolide-induced Transrepression of IL-8 NF-kappaB in Lung Epithelial Cells
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Jee YK, Kim YS, Yun SY, Kim YH, Choi EK, Park JS, Kim KY, Chea GN, Kwak SJ, Lee KY
- KMID: 2160056
- Tuberc Respir Dis.
- 2001 Jan;50(1):52-66.
- doi: 10.4046/trd.2001.50.1.52
BACKGROUND: NF-κB is the most important transcriptional factor in Il-8 gene expression. Triptolide is a new compound that recently has been shown to inhibit NF-κB activation. The purpose of this... -
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- Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription
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Lee J, Chun SK, Son GH, Kim K
- KMID: 2407090
- Endocrinol Metab.
- 2015 Sep;30(3):381-388.
- doi: 10.3803/EnM.2015.30.3.381
BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we... -
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- Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer
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Song HM, Park GH, Eo HJ, Jeong JB
- KMID: 2170525
- Biomol Ther.
- 2016 Mar;24(2):140-146.
- doi: 10.4062/biomolther.2015.109
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. Activating transcription factor 3 (ATF3) is associated with apoptosis in human colon... -
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- Analysis of Glucocorticoid Response Element and TPA Response Element of Rat Thyrotropin-Releasing Hormine Gene by Site-Directed Mutagenesis
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Kim SW, Kim JW, Kim YS, Choi YK, Yang IM, Woo JT, Chung WW
- KMID: 2199458
- J Korean Soc Endocrinol.
- 1999 Jun;14(2):278-292.
BACKGROUND: We previously demonstrated that a GRE/TRE composite sequence, which is located between 200 bp and 220 bp relative to the transcriptional start site of rat TRH gene, is responsible... -
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- Chromatin organization and transcriptional activation of Hox genes
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Lee JY, Min H, Wang X, Khan AA, Kim MH
- KMID: 2168900
- Anat Cell Biol.
- 2010 Mar;43(1):78-85.
- doi: 10.5115/acb.2010.43.1.78
Spatially and temporally programmed expression of the Hox genes along the antero-posterior (A-P) axis is essential for correct pattern formation during embryonic development. An accumulating body of evidence indicates the... -
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- Small Double-Stranded RNA Mediates the Anti-Cancer Effects of p21(WAF1/ClP1) Transcriptional Activation in a Human Glioma Cell Line
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Dong Z, Dang Y, Chen Y
- KMID: 2386458
- Yonsei Med J.
- 2014 Mar;55(2):324-330.
PURPOSE: This study was conducted to investigate the small double-stranded RNA (dsRNA) mediated anti-tumor effects of p21(WAF1/ClP1) (p21) transcriptional activation in vitro in the human glioma SHG-44 cell line. MATERIALS AND... -
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- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta
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Kim SK, Avila JJ, Massett MP
- KMID: 2466570
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):53-68.
- doi: 10.4196/kjpp.2020.24.1.53
The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON,... -
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- Expression of G1 cell cycle related genes in triamcinolone acetonide treated keloid fibroblasts
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Woo SH, Seul JH, Suh SI, Baek WK, Suh MH
- KMID: 1941847
- J Korean Soc Plast Reconstr Surg.
- 1998 Feb;25(2):178-190.
The effect of triamcinolone acetonide(TA) on the expression of Gl related genes was investigated the cultured keloid fibroblast. The addition of TA to the culture medium resulted in growth inhibition... -
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- (E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-kappaB
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Kim Y, Jeong EJ, Han Lee IS, Kim MY, Cho JY
- KMID: 2150478
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):91-99.
- doi: 10.4196/kjpp.2016.20.1.91
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported... -
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- The Role of NF-kappaB RelA Subunit for Tax-inhibition of p53 Transcriptional Activity in Human T-cell Lymphotrophic Virus Type 1
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Jeong SJ, Lee JD, Jeong MH
- KMID: 1963271
- J Bacteriol Virol.
- 2004 Sep;34(3):231-237.
Human T-cell lymphotrophic virus type I (HTLV-I) is a causative agent of adult T-cell leukemia (ATL). The viral transcriptional activator Tax encoded by the HTLV-I genome is thought to play... -
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- Inhibitory mechanism on NF-kB transactivation by dexamethasone in pulmonary epithelial cells
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Lee KY, Kim YS, Ko MH, Park JS, Jee YK, Kim KY, Kwak SJ
- KMID: 2160221
- Tuberc Respir Dis.
- 2000 May;48(5):682-698.
- doi: 10.4046/trd.2000.48.5.682
Glucocorticoid receptor (GR) functions as a suppressor of inflammation by inhibiting the expression of many cytokine gene activated by NF-κB. The goal of this study is to investigate the mechanism... -
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- Radiation-induced Apoptotic Signaling Pathway in HL - 60 Cells
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Ahn SJ, Park RK, Lee SR, Chung WK, Nah BS, Nam TK, Chung HT, Moon SR, Kang HK, Park SJ
- KMID: 2137123
- J Korean Cancer Assoc.
- 2000 Feb;32(1):156-167.
PURPOSE: The mechanical insights of death of cancer cells by ionizing radiation are not yet clearly defined. Recent evidences have demonstrated that radiation therapy may induce cell death via activation of signaling pathway... -
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- Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor gamma Activity and on Glucose Uptake by Thiazolidinediones
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Lee KW, Ku YH, Kim M, Ahn BY, Chung SS, Park KS
- KMID: 2281640
- Diabetes Metab J.
- 2011 Aug;35(4):340-347.
- doi: 10.4093/dmj.2011.35.4.340
BACKGROUND: Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic beta-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor gamma (PPARgamma),... -
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- Hyperglycemia-induced Activation of Nuclear Transcription Factor kappaB in Cultured Fibroblasts and Endothelial Cells
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Kim KH, Kim BC, Lee KS
- KMID: 2250207
- Korean J Dermatol.
- 2003 Apr;41(4):423-428.
BACKGROUND: A common endpoint of hyperglycemia dependent cellular changes is the generation of reactive oxygen intermediates (ROIs) and the presence of elevated oxidative stress. Therefore, oxidative stress is supposed to... -
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