- Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling
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Krishnan J, Choi S
- KMID: 1806244
- Genomics Inform.
- 2012 Sep;10(3):153-166.
- doi: 10.5808/GI.2012.10.3.153
A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of... -
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- Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population
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Kim EJ, Chung WC, Lee KM, Paik CN, Jung SH, Lee BI, Chae HS, Choi KY
- KMID: 1792982
- J Korean Med Sci.
- 2012 Jan;27(1):72-77.
- doi: 10.3346/jkms.2012.27.1.72
The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of... -
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- Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation
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Lim BJ, Lee D, Hong SW, Jeong HJ
- KMID: 1727993
- Yonsei Med J.
- 2011 Jul;52(4):610-615.
- doi: 10.3349/ymj.2011.52.4.610
PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We... -
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- Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System
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Leem E, Jeong KH, Won SY, Shin WH, Kim SR
- KMID: 2349687
- Exp Neurobiol.
- 2016 Aug;25(4):147-155.
- doi: 10.5607/en.2016.25.4.147
Although accumulating evidence suggests that microglia-mediated neuroinflammation may be crucial for the initiation and progression of Parkinson's disease (PD), and that the control of neuroinflammation may be a useful strategy... -
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- An In Vitro Model to Probe the Regulation of Adipocyte Differentiation under Hyperglycemia
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Shilpa K, Dinesh T, Lakshmi BS
- KMID: 2174291
- Diabetes Metab J.
- 2013 Jun;37(3):176-180.
- doi: 10.4093/dmj.2013.37.3.176
BACKGROUND: The aim of this study was an in vitro investigation of the effect of high glucose concentration on adipogenesis, as prolonged hyperglycemia alters adipocyte differentiation. METHODS: 3T3-L1 preadipocytes differentiated in... -
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- Acanthopanax koreanum Nakai modulates the immune response by inhibiting TLR 4-dependent cytokine production in rat model of endotoxic shock
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Jung MG, Do GM, Shin JH, Ham YM, Park SY, Kwon O
- KMID: 2313695
- Nutr Res Pract.
- 2013 Dec;7(6):460-465.
The hepatoprotective activity of Acanthopanax koreanum Nakai extract (AE) was investigated against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-induced liver failure rats compared with that of acanthoic acid (AA) isolated from AE. Although D-GalN/LPS (250... -
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- Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4
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Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ
- KMID: 1786107
- J Korean Med Sci.
- 2014 May;29(5):662-668.
- doi: 10.3346/jkms.2014.29.5.662
The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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- Immunotoxicological Effects of Aripiprazole: In vivo and In vitro Studies
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Baek KS, Ahn S, Lee J, Kim JH, Kim HG, Kim E, Kim JH, Sung NY, Yang S, Kim MS, Hong S, Kim JH, Cho JY
- KMID: 2285580
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):365-372.
- doi: 10.4196/kjpp.2015.19.4.365
Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole.... -
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- Comparison of the effect of three licorice varieties on cognitive improvement via an amelioration of neuroinflammation in lipopolysaccharide-induced mice
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Cho MJ, Kim JH, Park CH, Lee AY, Shin YS, Lee JH, Park CG, Cho EJ
- KMID: 2442292
- Nutr Res Pract.
- 2018 Jun;12(3):191-198.
- doi: 10.4162/nrp.2018.12.3.191
BACKGROUND/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a... -
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- Association of Single Nucleotide Polymorphisms in the MD-2 Gene Promoter Region With Der p 2 Allergy
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Liao EC, Chang CY, Wu CC, Wang GJ, Tsai JJ
- KMID: 2260462
- Allergy Asthma Immunol Res.
- 2015 May;7(3):249-255.
- doi: 10.4168/aair.2015.7.3.249
PURPOSE: Sensitization to house dust mite (Dermatophagoides pteronyssinus) is a considerable risk factor for the progression of allergic disease. The group 2 allergen from Dermatophagoides pteronyssinus, Der p 2, is... -
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- EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model
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Kim MH, Chang HM, Kim TW, Lee SK, Park JS, Kim YH, Lee TY, Jang SJ, Suh CW, Lee TS, Kim SH, Lee SG
- KMID: 1779166
- J Korean Med Sci.
- 2009 Jun;24(3):474-480.
- doi: 10.3346/jkms.2009.24.3.474
EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12, IFN-gamma, and GM-CSF in vitro. To study the effects of these cytokines stimulated by EC-18 on cancer cells, we applied... -
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