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Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator

Lee C, Na JU, Lee JH, Han SK, Choi PC, Lee YH, Park SO, Shin DH

OBJECTIVE: Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed...
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Low- versus Standard-Dose Intravenous Alteplase in the Context of Bridging Therapy for Acute Ischemic Stroke: A Korean ENCHANTED Study

Kim JS, Kim YJ, Lee KB, Cha JK, Park JM, Hwang Y, Kim EG, Rha JH, Koo J, Kim J, Kim YJ, Seo WK, Kim DE, Robinson T, Lindley RI, Wang X, Chalmers J, Anderson C

BACKGROUND AND PURPOSE: Following the positive results from recent trials on endovascular therapy (EVT), bridging therapy (intravenous alteplase plus EVT) is increasingly being used for the treatment of acute ischemic...
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Ischemic Stroke Caused by a Hyaluronic Acid Gel Embolism Treated with Tissue Plasminogen Activator

Lee S, Jung JH, Seo J, Kim EG

No abstract available.
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Clinical Results of the Intra-Arterial Thrombolysis with Stent Retriever Device Weather Perfusion Diffusion Mismatching and Intravenous Tissue Plasminogen Activator Administration

Kim YJ, Cho KW, Kim SR, Yoo DS, Park HK, Ji C

OBJECTIVE: Intraarterial thrombolysis (IA-Tx) with stent retriever is accepted as an additional treatment for selected patients and the clinical benefit is well reported. Each intravenous tissue plasminogen activator administration (IV-tPA)...
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Emergent Double-barrel Bypass Shortly after Intravenous Administration of Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke

Choi JH, Park HS

Although intravenous recombinant tissue plasminogen activator (IV rt-PA) is effective in many cases of acute ischemic stroke, the neurologic symptoms can worsen after IV rt-PA because of sustained vessel occlusion....
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Association between the Alu Insertion/Deletion Polymorphism in the Tissue-Type Plasminogen Activator Gene and Mirtazapine Response in Koreans with Major Depression

Kim D, Chang HS, Won E, Ham BJ, Lee MS

OBJECTIVES: To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder...
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Intravenous Tissue Plasminogen Activator Improves the Outcome in Very Elderly Korean Patients with Acute Ischemic Stroke

Choi JC, Lee JS, Park TH, Park SS, Cho YJ, Park JM, Kang K, Lee KB, Lee SJ, Ko Y, Kim JG, Lee J, Cho KH, Kim JT, Yu KH, Lee BC, Oh MS, Cha JK, Kim DH, Nah HW, Kim DE, Ryu WS, Kim BJ, Bae HJ, Kim WJ, Shin DI, Yeo MJ, Sohn SI, Hong JH, Lee J, Hong KS

BACKGROUND AND PURPOSE: In a recent pooled analysis of randomized clinical trials (RCTs), intravenous tissue plasminogen activator (TPA) improves the outcome in patients aged > or =80 years. However, it...
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Combined Phacoemulsification, Synechiolysis without Gonioprism Lens and Intracameral Tissue Plasminogen Activator Injection for Angle-Closure Glaucoma

Cho SH, Kee CW

PURPOSE: In this study we evaluated the safety and efficacy of combined phacoemulsification and synechiolysis without aid of gonioprism lens and intraoperative intracameral tissue plasminogen activator (tPA) injection for angle-closure...
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Outcomes of Endovascular Mechanical Thrombectomy and Intravenous Tissue Plasminogen Activator for the Treatment of Vertebrobasilar Stroke

Brinjikji , Rabinstein AA, Clofta HJ

  • KMID: 2400170
  • J Clin Neurol.
  • 2014 Jan;10(1):17-23.
BACKGROUND AND PURPOSE: Aggressive treatment of posterior-circulation occlusions is important due to the high rates of morbidity and mortality associated with these infarctions. A large administrative database was evaluated to...
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Zinc-Triggered Induction of Tissue Plasminogen Activator and Plasminogen in Endothelial Cells and Pericytes

Cho MK, Sun ES, Kim YH

Cerebral amyloid angiopathy (CAA) is common in patients with Alzheimer's disease (AD) and may contribute to cerebral hemorrhage. We previously demonstrated that tissue plasminogen activator (tPA) and plasminogen (PLG) accumulated...
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Recanalization Rate and its Associated Factors after Intravenous Tissue Plasminogen Activator Thrombolysis for Acute Major Cerebral Arterial Occlusion

Yoon WK, Kim YW, Kim SR, You SH, Park IS, Kim SD, Baik MW

  • KMID: 2089921
  • Korean J Cerebrovasc Surg.
  • 2007 Dec;9(4):265-270.
PURPOSE: To investigate the recanalization rate after intravenous administration of recombinant tissue plasminogen activator (IV-tPA) for acute major arterial occlusion of the anterior cerebral circulation and to investigate the relationship...
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Efficacy of tissue Plasminogen Activator in Patients with Massive Subarachnoid Hemorrhage by Aneurysmal Rupture

Kwon S, Park JB, Kim HJ, Kwun BD

  • KMID: 2256664
  • Korean J Cerebrovasc Surg.
  • 2006 Sep;8(3):200-205.
OBJECTIVE: There is a close relationship between the amount of hematoma and vasospasm in aneurysmal subarachnoid hemorrhage (SAH). Tissue plasminogen activator (t-PA) has been used as a safe agent to...
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A Case of Femoral Artery Thrombosis Following Cardiac Cathetherization Treated with Recombinant Tissue Plasminogen Activator in Neonate

Han JJ, Ko HK, Yoo Y, Jang GY, Son CS, Lee JW, Kang CH

  • KMID: 1852895
  • J Korean Pediatr Cardiol Soc.
  • 2006 Sep;10(3):334-338.
Femoral artery thrombosis is an uncommon but potentially serious complication following pediatric cardiac catheterization. Treatment options of thrombosis include intravenous heparin infusion, thrombolytic therapy such as streptokinase, urokinase and tissue...
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Effects of Neodymium:YAG Laser and Tissue Plasminogen Activator on Massive Diabetic Premacular Hemorrhage

Park YH, Lee WK, Chung J, Kim HS, Lee YC

  • KMID: 2337406
  • J Korean Ophthalmol Soc.
  • 2006 Jun;47(6):971-976.
PURPOSE: To investigate the combined therapeutic effects of Neodymium:YAG (Nd:YAG) laser membranotomy and intravitreal tissue plasminogen activator (tPA) on massive diabetic premacular hemorrhage. METHODS: The authors performed Nd:YAG laser membranotomy...
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The Effect of Primary Percutaneous Coronary Intervention after the Administration of Tirofiban Alone or Tirofiban Combined with Low dose Alteplase in Patients with Acute Myocardial Infarction on ST Elevation Resolution, TIMI Flow and Short-Term Clinical Outcomes

Kim SP, Cho JH, Chae DR, Yeom SM, Jeon WJ, Kim SH, O YS, Yang HS, Kim DH, Bae Y, Kim JY, Jeong MH

BACKGROUND AND OBJECTIVES: The combination of platelet glycoprotein IIb/IIIa inhibitors and a low dose thrombolytic agent may produce early Thrombolysis In Myocardial Infarction (TIMI) 3 flow and a high rate...
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The Effect of Recombinant Tissue Plasminogen Activator on the Intracerebral Hematomas in Experimental Cat Models

Jo KW, Kim SR, You SH, Kim SD, Park IS, Baik MW

  • KMID: 1956357
  • J Korean Neurosurg Soc.
  • 2005 Apr;37(4):287-292.
OBJECTIVE: Recent clinical studies have demonstrated that intracisternal administration of recombinant tissue plasminogen activator(rt-PA) can facilitate the normal clearing of blood from the subarachnoid space. Urokinase, a first generation fibrinolytic...
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Retnal Toxicty of Intravitreal Tissue Plasminogen Activator with C3F8 Injection in Rabbit Eyes

Kim KS, Rhee K, Huh K

  • KMID: 2125996
  • J Korean Ophthalmol Soc.
  • 2004 Jul;45(7):1181-1188.
PURPOSE: To determine the concentration at which a mixed injection of tissue plasminogen activator (tPA) and C3F8 gas is toxic, we studied the histopathological changes in the rabbit retina. METHODS:...
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The Effect of Tissue Plasminogen Activator on Intimal Hyperplasia after Balloon Injury to Rat Aorta

Lee JK, Kwun WH, Hwang JS, Suh BY, Kwun KB

  • KMID: 1941029
  • J Korean Soc Vasc Surg.
  • 2004 Dec;20(2):186-191.
PURPOSE: Thrombus formation enhances both neointima formation and clinical restenosis after vascular injury or angioplasty. Thrombotic occlusions and intimal hyperplasia limit the success of vascular reconstructive procedures. Thrombolysis is expected...
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Effects of local irrigation and intravenous administration of human tissue-type plasminogen activator on microvascular thrombosis

Ryu SH, Seo IY, Park HJ, Oh HK, Ryu SY, Kim OJ, Choi JH

  • KMID: 2183952
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2003 Sep;25(5):398-404.
This study was performed to evaluate the effect of local irrigation and intravenous administration of human tissue-type plasminogen activator (t-PA). Nine rabbits weighing about 2 kg were used. After exposure...
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Pneumatic Displacement of Submacular Hemorrhage with Intravitreal Injection of SF6 Gas without Tissue Plasminogen Activator

Ahn YS, Lee SJ, Park S

  • KMID: 2206748
  • J Korean Ophthalmol Soc.
  • 2003 Dec;44(12):2811-2815.
PURPOSE: To assess the efficacy and safety of intravitreal injection of SF6 gas for the displacement of submacular hemorrhage without use of tissue plasminogen activator (tPA) METHODS: Three hundred microliter...
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