Korean Circ J.  1993 Jun;23(3):356-362. 10.4070/kcj.1993.23.3.356.

Clinical significance of plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in chronic stable angina

• Choi YJ
• Park SS
• Park SW
• Sohn DW
• Oh BH
• Lee MM
• Park YB
• Choi YS
• Seo JD
• Lee YW

• KMID: 2229227
• DOI: http://doi.org/10.4070/kcj.1993.23.3.356

Abstract

BACKGROUND
Impaired fibrinolytic system has been considered to play an important role in the pathogenesis of coronary artery disease, especially associated with thrombus formation. To evaluate the pathogenetic role of fibrinolytic system in coronary artery disease, major determinants of fibrinolytic system, tissue plasminogen activator(t-PA) and palsminogen activator inhibitor-1(PAI-1) levels were measured in control(n=7) and chronic stable angina patients(n=7). METHODS: Blood samplings were done in resting state, venous occlusion and peak exercise. Levels of plasma t-PA antigen and PAI-1 antigen were measured by ELISA method. RESULTS: 1) In resting state, there was no significant difference in plasma level of t-PA(control group : 9.15+/-2.82ng/ml vs, study group ; 9.65+/-3.53ng/ml) and PAI-1(control group ; 20.27+/-9.98ng/ml vs, study group ; 17.43+/-3.53ng/ml) between each group. 2) With venous occlusion test, increment of plasma t-PA level was noted in both groups which was lower in patient group, however, this difference in increment was not statistically significant. 3) Increased plasma t-PA level was noted after exercise in both groups. 4) Plasma level of PAI-1 was not significantly changed after venous occlusion or exercise in both groups. CONCLUSIONS: In patients with chronic stable angina, there was no definite evidence of impaired fibriolytic system although plasma t-PA increased somewhat less after venous occlusion in patients with chronic stable angina than control.

Keyword

Coronary artery disease; Tissue type plasminogen activator; Plasminogen activator inhibitor-1

MeSH Terms

Angina, Stable*
Coronary Artery Disease
Enzyme-Linked Immunosorbent Assay
Humans
Plasma*
Plasminogen Activator Inhibitor 1
Plasminogen Activators*
Plasminogen*
Thrombosis
Tissue Plasminogen Activator*
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators
Tissue Plasminogen Activator