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Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells

Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ

Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of...
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Multiple Intracranial Hemorrhage Following Intravenous Recombinant Plasminogen Activator in the Patients Taking Rivaroxaban

Ryu JC, Kwon JH, Choi SH, Kim WJ

No abstract available.
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Overexpression of Plasminogen Activator Inhibitor-1 in Advanced Gastric Cancer with Aggressive Lymph Node Metastasis

Suh YS, Yu J, Kim BC, Choi B, Han TS, Ahn HS, Kong SH, Lee HJ, Kim WH, Yang HK

PURPOSE: The purpose of this study is to investigate differentially expressed genes using DNA microarray between advanced gastric cancer (AGC) with aggressive lymph node (LN) metastasis and that with a...
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Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132

Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI

  • KMID: 1502511
  • Biomol Ther.
  • 2013 Mar;21(2):107-113.
Plasminogen activator inhibitor-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue plasminogen activator (tPA). In CNS, tPA/PAI-1 activity is involved in the regulation...
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Plasminogen Activator Inhibitor Type 1 (PAI-1) A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma

Lim JE, Park MS, Kim EY, Jung JY, Kang YA, Kim YS, Kim SK, Shim HS, Cho BC, Chang J

  • KMID: 2320460
  • Tuberc Respir Dis.
  • 2013 Oct;75(4):140-149.
BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1), an important regulator of plasminogen activator system which controls degradation of extracellular membrane and progression of tumor cells, and PAI-1 gene polymorphic variants...
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Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease

Han MY

PURPOSE: To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients. METHODS: PCR-RFLP of PAI- 1 promotor...
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Polymorphism of Plasminogen Activator Inhibitor-1 and Development of Diabetic Renal Failure in Koreans

Kim Y, Jin H, Sohn SS, Park B, Lee SH, Lee TW, Ihm CG, Kim MJ

  • KMID: 2079446
  • Korean J Nephrol.
  • 2005 Mar;24(2):223-229.
BACKGROUND: An elevated plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a factor for the development of macroangiopathy including myocardial infarction, and an association between polymorphism of the...
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Plasminogen Activator Inhibitor-1 in Asthma

  • KMID: 2090084
  • Korean J Asthma Allergy Clin Immunol.
  • 2004 Jun;24(2):176-185.
Plasminogen activator inhibitor (PAI)-1 is a serine protease that, in addition to its major role in hemostasis, is known to play an essential role in tissue remodeling. Recent evidence indicates...
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Plasminogen Activator Inhibitor Type 1 Gene Polymorphism in Patients with Minimal Change Nephrotic Syndrome

Kim YM, Hong HK, Kim SD, Cho BS

  • KMID: 2197650
  • J Korean Soc Pediatr Nephrol.
  • 2004 Apr;8(1):26-32.
PURPOSE: Hypercoagulability is present in patients with nephrotic syndrome. Plasminogen activator inhibitor type 1(PAI-1) is a major inhibitor of plasminogen activators. PAI-1 inactivates both tissue plasminogen activator(tPA) and urokinase plasminogen...
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Urokinase Plasminogen Activator Receptor Gene Expression and Clinico-Pathologic Feature in Gastric Cancer Patients

Kim YG, Lee KH, Kim MK, Lee JL, Hyun MS, Kim SH, Kim HS

  • KMID: 2372332
  • J Korean Gastric Cancer Assoc.
  • 2004 Dec;4(4):207-212.
PUPOSE: Invasion and metastasis in solid tumors require the action of tumor-associated proteases. The serine protease urokinase-type plasminogen (uPA) and receptor (uPAR) appear to have a major function in these...
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Invasion-Metastasis by Hepatocyte Growth Factor/c-Met Signaling Concomitant with Induction of Urokinase Plasminogen Activator in Human Pancreatic Cancer: Role as Therapeutic Target

Lee KH, Hyun MS, Kim JR

  • KMID: 2166178
  • Cancer Res Treat.
  • 2003 Jun;35(3):207-212.
PURPOSE: Increased expression of the hepatocytes growth factor (HGF) receptor (c-Met) and urokinase type plasminogen activator (uPA) correlate with the development and metastasis of cancers. However, the mechanisms by which...
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Plasminogen Activator Inhibitor-1 (PAI-1)/tissue Plasminogen Activator (t-PA) Levels and PAI-1 4G/5G Promoter Polymorphism in Type 2 Diabetes with Microalbuminuria

Kwon SH, Park YJ, Jeong IK, Koh JJ, Park KS, Kim SY, Lee HK

  • KMID: 1767997
  • J Korean Diabetes Assoc.
  • 2003 Jun;27(3):186-198.
BACKGROUND: Persistent microalbuminuria in diabetic patients is a risk factor of cardiovascular mortality. Increased plasma plasminogen activator inhibitor type-1 (PAI-1) levels have been observed in diabetic patients with overt nephropathy....
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Relationship Between Diabetic Nephropathy and Plasminogen Activator Inhibitor-1

Cha BS, Kim HJ

  • KMID: 1767996
  • J Korean Diabetes Assoc.
  • 2003 Jun;27(3):179-185.
No abstract available.
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Expression of Urokinase-type Plasminogen Activator (uPA) and Plasminogen Activator Inhibitor-1 (PAI-1) in Gallbladder Carcinoma

Lee KH, Kang HJ, Lee SY, Park MH

  • KMID: 1979366
  • Korean J Pathol.
  • 2003 Dec;37(6):384-392.
BACKGROUND: There are evidences that uPA and its inhibitor play a key role in tumor spread. We studied whether uPA and PAI-1 expressions could serve as prognostic parameters along with...
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Epidermal Growth Factor Dependent Expression of Plasminogen Activator and Plasminogen Activator Inhibitor in Rat Hepatocytes in Primary Culture

Yoon WH, Choi JH, Jung YJ, Lee BH, Kim TD, Song IS, Bae JS, Lim K, Hwang BD

  • KMID: 2095927
  • J Korean Surg Soc.
  • 2001 Sep;61(3):237-246.
PURPOSE: In order to clarify the the role of epidermal growth factor (EGF) in the regulation of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) during liver regeneration, we investigated...
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Polymorphisms of Angiotensin Converting Enzyme and Plasminogen Activator Inhibitor-1 Genes in Diabetic Nephropathy and Macroangiopathy in NIDDM Patients

Yoon JW, Jo SK, Han SY, Cha DR, Cho WY, Kim HK

  • KMID: 2079176
  • Korean J Nephrol.
  • 2001 Jul;20(4):565-575.
BACKGROUND: Although development of DM nephropathy in NIDDM patients is associated with poorly controlled blood sugar level and hypertension, relationship of genetic factor is also emphasized. Recent studies showed...
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Fibrinogen, Factor VII and Plasminogen Activator Inhibitor-1 Genotypes and the Risk of Coronary Artery Disease

Kim HK, Song KS, Jee SH, Shim WH, Shin JS

  • KMID: 2083431
  • Korean J Hematol.
  • 2001 Feb;36(1):79-89.
OBJECTIVE: The aims of this study were to investigate the extent to which specific known polymorphisms of fibrinogen, factor VII (FVII) and PAI-1 genes are associated with their respective plasma...
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Plasminogen Activator Inhibitor-1, c-erbB2, and p53 Protein Overexpression and Prognosis in Gastric Adenocarcinoma

Park A, Jin SY, Kim DW, Lee DW

  • KMID: 2011740
  • Korean J Pathol.
  • 2000 Aug;34(8):559-566.
Despite its fall in incidence, gastric adenocarcinoma remains a common disease with dismal prognosis worldwide. A better understanding of its tumorigenesis and biologic properties of tumor cells related to invasion...
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Clinical Significance of Urokinase - type Plasminogen Activator Receptor ( uPAR ) Expression in Breast Cancer Tissues

Gong SJ, Rha SY, Jung HC, Park JO, Yoo NC, Roh JK, Yang WI, Lee KS, Min JS, Kim BS, Chung HC

  • KMID: 2137111
  • J Korean Cancer Assoc.
  • 2000 Feb;32(1):53-59.
PURPOSE: Cancer invasion is induced by several proteolytic enzyme systems associated with the destruction of basement membrane and extracellular matrix. Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have been reported as...
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Interleuken-1beta induces bone resorption by regulation of prostaglandin E2 synthesis and plasminogen activator activity, and TGF-beta inhibits bone resorption of rat bone cells

Kim YH, Lee YJ, Chung KR, Park YG

  • KMID: 1576263
  • Korean J Orthod.
  • 2000 Dec;30(6):713-721.
Bone cells produce multiple growth factors and cytokines that have effects on bone metabolism and can be incorporated into the bone matrix. The present study was designed to extend these...
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