Korean J Cerebrovasc Surg.  2003 Sep;5(2):153-157.

Protracted Perihematomal Edema after Fibrinolysis Therapy with Urokinase

• Seo DH

Abstract

There is increasing evidence that thrombin is directly involved in the pathogenesis of cerebral edema after intracerebral hemorrhage. Some authors emphasize that early removal of hematoma using plasminogen activator can be an effective intervention that interrupts the cascade of events leading to increasing edema formation and white matter injury. Recently, there are many reports of the edema intensification following plasminogen activator-induced lysis of the intracerebral clot. The author reports a case who showed protracted perihematomal edema after hematoma evacuation and fibrinolysis therapy with urokinase. Considering that the benefit obtained from fibrinolysis therapy may be offset by an accentuation of its toxic edematous effect, further investigation into the use of urokinase for hematoma evacuation should be undertaken.

Keyword

Intracerebral hemorrhage; Edema; Urokinase

MeSH Terms

Brain Edema
Cerebral Hemorrhage
Edema*
Fibrinolysis*
Hematoma
Plasminogen
Plasminogen Activators
Thrombin
Urokinase-Type Plasminogen Activator*
Plasminogen
Plasminogen Activators
Thrombin
Urokinase-Type Plasminogen Activator