Korean J Thorac Cardiovasc Surg.
2008 Aug;41(4):484-488.
Thrombolytic Therapy for Repeated Prosthetic Valvular Thrombosis That's Associated with Pregnancy under Heparin Anticoagulation
- Affiliations
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- 1Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Yongsan Hospital, Chung-Ang University College of Medicine, Korea.
- 2Department of Thoracic and Cardiovascular Surgery, Seoul Paik Hospital, Inje University College of Medicine, Korea. yongin@hotmail.com
Abstract
- During long-term anticoagulation treatment with using heparin in a pregnant patient with a mechanical mitral prosthesis, we observed several anticoagulation-related complications, including repeated prosthetic valve thrombosis. This was found to be caused by heparin resistance due to an anti-thrombin III deficiency. Thrombolytic therapy using urokinase or tissue plasminogen activator (tPA) was successful and safe for her as well as her baby.
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