J Korean Ophthalmol Soc.  1997 Apr;38(4):692-697.

Treatment of Total Hyphema Following Trauma and Surgery with Tissue Plasminogen Activator

• Chung SM
• Koo TH
• Kim MH
• Kim SM

Abstract

Delayed clearing from the total hyphema resulting from ocular trauma and surgery causes intractable glaucoma and corneal staining by blood-pigments such as hemoglobin and small amounts of hemosiderin. The management of hyphema includes supportive medical care such as bed rest and surgical procedures such as paracentesis and removal of blood clot to enhance the secretory function of trabecular meshwork. However, surgical intervention has many complications and should be used only when it is absolutely necessary. We used the recombinant intraocular tissue plasminogen activator as a method for minimizing complications and sequeles in three patients with total hyphema. Hyphema resolved in all patients who had been treated with 10ug of recombinant tissue plasminogen activator following 5 days medical treatment. In study, we experienced a case of vitreous hemorrhage. In conclusion, we recommend that eyes with complicated large or total hyphema may be considered for intracameral tissue plasminogen activator as a first procedure comparing to surgical intervention, but further invesigation is needed for timing and dosage of drug usage.

Keyword

Hyphema; Tissue plasminogen activator

MeSH Terms

Bed Rest
Glaucoma
Hemosiderin
Humans
Hyphema*
Paracentesis
Tissue Plasminogen Activator*
Trabecular Meshwork
Vitreous Hemorrhage
Hemosiderin
Tissue Plasminogen Activator