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The role of tiotropium in the management of asthma

Park HW

Asthma is a chronic respiratory disease characterized by reversible airway obstruction that is secondary to an allergic inflammation and excessive smooth muscle contraction. Cholinergic signals were known to contribute significantly...
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Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma

Kang JY, Kim IK, Hur J, Kim SC, Lee SY, Kwon SS, Kim YK

BACKGROUND: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly...
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Effect of Inhaled Tiotropium on Spirometric Parameters in Patients with Tuberculous Destroyed Lung

Yum HK, Park IN

BACKGROUND: In Korea, patients with destroyed lung due to tuberculosis (TB) account for a significant portion of those affected by chronic pulmonary function impairment. The objective of our research was...
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A Comparison of International Guidelines for Pediatric Asthma Pharmacotherapy

Kwon TH, Sohn K, Baek IH

OBJECTIVE: International institutes such as Global institute for Asthma(GINA), KAAACI(Republic of Korea), NHLBI(USA), BTS(UK) and JSA(Japan) have published guidelines for asthma treatment. The aim of this study was to compare...
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Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma

Aalbers R, Park HS

Despite a range of efficacious therapies for asthma, including inhaled corticosteroids (ICS) and long-acting β₂-agonists (LABA), a significant proportion of patients have poor asthma control and retain a risk of...
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The Role of Tiotropium+Olodaterol Dual Bronchodilator Therapy in the Management of Chronic Obstructive Pulmonary Disease

Halpin DM

Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global Obstructive Lung Disease Initiative (GOLD). Long acting anti-muscarinics...
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Issues on Safety of Long-Acting Muscarinic Antagonist

Lee YD, Cho Y, Han MS

  • KMID: 2319504
  • Tuberc Respir Dis.
  • 2011 May;70(5):384-389.
The prevention of and the controlling of symptoms, reductions in the frequency of exacerbations, and disease severity are central to the pharmacologic therapy of chronic obstructive pulmonary disease (COPD). COPD...
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Add-on Therapy for Symptomatic Asthma despite Long-Acting Beta-Agonists/Inhaled Corticosteroid

Dreher M, Müller T

Asthma, remains symptomatic despite ongoing treatment with high doses of inhaled corticosteroids (ICS) in conjunction with long-acting beta-agonists (LABA), is classified as “severe” asthma. In the course of caring for...
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Effect of inhaled tiotropium on patients with COPD

Kang YI, Noh TJ, Choi HS, Choi CW, Park MJ, Kang HM, Yoo JH

  • KMID: 2305915
  • Korean J Med.
  • 2007 Aug;73(2):159-168.
BACKGROUND: Tiotropium is a long acting anticholinergic bronchodilator and it reduces exacerbations and improves the quality of life of patients with stable chronic obstructive pulmonary disease (COPD). The purpose of...
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Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation

Sunwoo J, Rhee SJ, Lee S, Lee SW, Jung J, Son H, Jang IJ

Chronic obstructive pulmonary disease (COPD) is a type of progressive, obstructive lung disease characterized by long-term poor airflow. The symptoms of COPD may be relieved and its progression delayed by...
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Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Lin J, Wan H, Kang J, Ma Q, Chen P, Jin M, Wang H, Liu S, Hao Q, Lin Y, Su L, Hu N

PURPOSE: Asthma affects approximately 30 million patients in China; however, tiotropium data for Chinese patients is limited. This study aimed to assess the efficacy and safety of tiotropium in Chinese...
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Comparison for the Effects of Triple Therapy with Salmeterol/Fluticasone Propionate and Tiotropium Bromide versus Individual Components in Patients of Severe COPD Combined with Bronchial Hyperresponsiveness

Sohn JY, Kim SR, Park SJ, Lee HB, Lee YC, Rhee YK

  • KMID: 2319294
  • Tuberc Respir Dis.
  • 2009 Dec;67(6):536-544.
BACKGROUND: A combination of salmeterol and fluticasone propionate (SFC) and tiotropium bromide (TIO) is commonly prescribed for COPD patients but there is little data on their effectiveness, particularly in COPD...
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Optimal Bronchodilation for COPD Patients: Are All Long-Acting β₂-Agonist/Long-Acting Muscarinic Antagonists the Same?

Miravitlles M, Baek S, Vithlani V, Lad R

Bronchodilators provide improvements in lung function and reductions in symptoms and exacerbations, and are the mainstay of pharmacological management of chronic obstructive pulmonary disease (COPD). The Global Initiative for Chronic...
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A Comparison of Tiotropium 18microgram, Once Daily and Ipratropium 40microgram, 4 Times Daily in a Double-Blind, Double-Dummy, Efficacy and Safety Study in Adults with Chronic Obstructive Pulmonary Disease

Kim SJ, Kim MS, Lee SH, Kim YK, Moon HS, Park SH, Lee SY, In KH, Lee CY, Kim YS, Kim HJ, Ahn CM, Kim SK, Kim KR, Cha SI, Jung TH, Kim MO, Park SS, Choi CW, Yoo JH, Kang HM, Koh WJ, Ham HS, Kang EH, Kwon OJ, Lee YD, Lee HB, Lee YC, Rhee YK, Shin WH, Kwon SY, Kim WJ, Yoo CG, Kim YW, Shim YS, Han SK, Park HK, Kim YS, Lee MK, Park SK, Kim MH, Lee WY, Yong SJ, Shin KC, Choi BW, Oh YM, Lim CM, Lee SD, Kim WS, Kim DS, Jung SS, Kim JO, Ko YC, Kim YC, Yoo NS

  • KMID: 2318618
  • Tuberc Respir Dis.
  • 2005 May;58(5):498-506.
BACKGROUND: This study compared the bronchodilator efficacy and safety of tiotropium inhalation capsules (18microgram once daily) with a ipratropium metered dose inhaler (2 puffs of 20microgram q.i.d.) in patients with...
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