- Thromboxane A2 Receptor (T924C) Polymorphism is Associated with Lower Pulmonary Function in Korean Children with Asthma
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- KMID: 2299780
- Korean J Asthma Allergy Clin Immunol.
- 2005 Mar;25(1):34-38.
BACKGROUND: Thromboxane A2 and its receptor (TBXA2R) are involved in the constriction of vascular and respiratory smooth muscle, which may play a role in the thickening and remodeling of the... -
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- Thromboxane in Pregnancy-Induced Hypertension
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Lee KC, Lee KM, Lee CH, Kim SJ, Yun BI, Chung DY
- KMID: 2077144
- Korean J Obstet Gynecol.
- 2004 Sep;47(9):1680-1683.
OBJECTIVE: High thromboxane level evidence supports pivotal involvement of TxA2 in pathophysiology of pregnancy induced hypertension and provides a strong rationale for pursuing TxA2-blocking strategies in drug development. METHODS: The stable... -
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- Thromboxane A2 Synthetase Inhibitor Plus Low Dose Aspirin : Can It Be a Salvage Treatment in Acute Stroke Beyond Thrombolytic Time Window
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An GH, Sim SY, Jwa CS, Kim GH, Lee JY, Kang JK
- KMID: 2066843
- J Korean Neurosurg Soc.
- 2011 Jul;50(1):1-5.
- doi: 10.3340/jkns.2011.50.1.1
OBJECTIVE: There is no proven regimen to reduce the severity of stroke in patients with acute cerebral infarction presenting beyond the thrombolytic time window. Ozagrel sodium, a selective thromboxane A2... -
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- Endoperoxides and Thromboxane A2 in Porcine Coronary Arteries with Regenerated Endothelium
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Kim JJ, Park SJ, Lee JK, Lee YW
- KMID: 1670927
- Korean Circ J.
- 1994 Apr;24(2):280-290.
- doi: 10.4070/kcj.1994.24.2.280
BACKGROUND: Endothelin-1 is a potent vasoconstrictor substance that causes slow and longlasting contractions of isolated blood vessels. In the aorta of the spontaneously hypertensive rat, endothelin-1 stimulates the release of... -
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- Two cases of Ticlopidine-induced neutropenia in patients with cardiovascular disease
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Chae GS, Yoo HS, Jee JH, Lee JM, Ahn JS, Lee JA, Park YS, Doo YC, Han KR, Oh DJ, Rhim CY
- KMID: 2228923
- Korean Circ J.
- 1998 Feb;28(2):280-283.
- doi: 10.4070/kcj.1998.28.2.280
Ticlopidine is an antiplatelet agent used as a drug to prevent the recurrence of cerebral infarction or ischemic heart disease. Close attention has recently been paid to the superiority of... -
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- Evaluation of Cerebrospinal Fluid Levels of Thromboxane B2 and 6-ketoprostaglandin F1alpha in Patients with Aneurysmal Subarachnoid Hemorrhage
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Kim SY, Yim MB, Son EI, Kim IH, Lee IK
- KMID: 2067786
- J Korean Neurosurg Soc.
- 1989 May;18(5):671-679.
In order to find out the relationship between arachidonic acid(AA) metabolites and the development of vasospasm following a subarachnoid hemorrhage(SAH), we evaluated the cerebrospinal fluid(CSF) levels of the two main... -
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- Stroke Update 2011: New Antithrombotics
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Seo KD, Lee KY
- KMID: 2288709
- Korean J Stroke.
- 2012 Aug;14(2):62-66.
Several new antithrombotic drugs have been developed and approved to use in clinical practice recently. Dabigatran, a direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor, have been approved in... -
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- Involvement of Thromboxane A2 in the Modulation of Pacemaker Activity of Interstitial Cells of Cajal of Mouse Intestine
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Kim JH, Choi SJ, Yeum CH, Yoon PJ, Choi S, Jun JY
- KMID: 2071642
- Korean J Physiol Pharmacol.
- 2008 Feb;12(1):25-30.
- doi: 10.4196/kjpp.2008.12.1.25
Although many studies show that thromboxane A2 (TXA2) has the action of gastrointestinal (GI) motility using GI muscle cells and tissue, there are no reports on the effects of TXA2... -
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- Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves
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Kim JH, Lee J, Kang S, Moon H, Chung KH, Kim KR
- KMID: 2374621
- Biomol Ther.
- 2016 Nov;24(6):659-664.
- doi: 10.4062/biomolther.2016.021
Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities.... -
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- Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells
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Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH
- KMID: 756282
- Exp Mol Med.
- 2009 Jan;41(1):17-24.
- doi: 10.3858/emm.2009.41.1.003
Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we... -
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- Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets
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Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ
- KMID: 2170686
- Biomol Ther.
- 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),... -
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- Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat
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Park SJ, Yoo HY, Kim HJ, Kim JK, Zhang YH, Kim SJ
- KMID: 2285441
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):59-64.
- doi: 10.4196/kjpp.2012.16.1.59
Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by... -
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- Disappearance of Hypoxic Pulmonary Vasoconstriction and O2-Sensitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia
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Yoo HY, Kim SJ
- KMID: 1500243
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):463-468.
- doi: 10.4196/kjpp.2013.17.5.463
Acute hypoxia induces contraction of pulmonary artery (PA) to protect ventilation/perfusion mismatch in lungs. As for the cellular mechanism of hypoxic pulmonary vasoconstriction (HPV), hypoxic inhibition of voltage-gated K+ channel... -
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- Effect of CLA (Conjugated Linoleic Acid) on the Anti-Atherosclerotic Factors in Human Hepatoma HepG2 Cells
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Oh H, Mun H, Lee M
- KMID: 2269778
- Korean J Nutr.
- 2004 Apr;37(3):182-192.
Conjugated linoleic acid (CLA) is the mixture of positional and geometric isomers of linoleic acid (LA), which is found abundantly in dairy products and meats. This study was performed to... -
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- Effect of Aprotinin on Changes in Plasma Thromboxane B2 and Endothelin-1 Concentratin after Extracorporeal Circulation
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Lim C, Yun TC, Kim YS, Kim SH, Lee JD, Rho JR, Song MK
- KMID: 1581859
- Korean J Thorac Cardiovasc Surg.
- 2000 Mar;33(3):221-229.
BACKGROUND: Thromboxane A2 and endothelin-1 are the potent vasoconstrictors affecting pulmonary pathophysiology in response to whole body inflammatin following CPB. Aprotinin, as an antiiflammatory agent, may decrease the release of such vasoactive... -
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- Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum
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Nguyen HB, Lee SY, Park SH, Han JH, Lee MY, Myung SC
- KMID: 1791427
- Korean J Physiol Pharmacol.
- 2015 May;19(3):257-262.
- doi: 10.4196/kjpp.2015.19.3.257
It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood.... -
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- The Inhibitory Effect of Eupatilin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Kim HD, Jeong JH
- KMID: 1432760
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):31-36.
- doi: 10.4196/kjpp.2013.17.1.31
The present study was undertaken to investigate the influence of eupatilin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used... -
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- Mechanisms of Platelet Activation and Integrin alphaIIbeta3
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Joo SJ
- KMID: 2028756
- Korean Circ J.
- 2012 May;42(5):295-301.
- doi: 10.4070/kcj.2012.42.5.295
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is... -
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- The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
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Je HD, Kim HD, La HO
- KMID: 2170648
- Biomol Ther.
- 2014 Mar;22(2):100-105.
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of... -
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- The Effect of The Coadministration of Vitamin E in Cyclosporine A(CsA) Induced Acute Nephrotoxicity in Rats
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Shin ES, Kim YW, Kim YJ, Park YH
- KMID: 2198894
- J Korean Soc Transplant.
- 1997 May;11(1):11-20.
Cyclosporine A(CsA) induced nephrotoxicity is a common clinical problem in the patients who underwent organ transplantation and subsequent immunosuppressive therapy. The precise pathophysiology of CsA induced nephrotoxicity still remains uncertain... -
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