Korean J Asthma Allergy Clin Immunol.  2005 Mar;25(1):34-38.

Thromboxane A2 Receptor (T924C) Polymorphism is Associated with Lower Pulmonary Function in Korean Children with Asthma

Abstract

BACKGROUND
Thromboxane A2 and its receptor (TBXA2R) are involved in the constriction of vascular and respiratory smooth muscle, which may play a role in the thickening and remodeling of the airway. Thromboxane A2 receptor polymorphism was recently found to be associated with asthma.
OBJECTIVE
We evaluated whether thromboxane A2 receptor (T924C) gene polymorphism is associated with the asthma phenotype and pulmonary function in Korean children with atopic asthma. METHOD: The subjects comprised 240 atopic asthmatic and 106 non-atopic healthy children. Asthma phenotypes and bronchial responsiveness to methacholine were determined by a physician. Thromboxane A2 receptor polymorphism was genotyped using PCR-RFLP assays. RESULT: The genotype frequency of thromboxane A2 receptor polymorphism was not statistically different between atopic asthma and non-atopic healthy controls. In contrast, the FEV1 (%) and FEF25~75%(%) were lower in children with homozygous (CC) and heterozygous (CT) for mutant alleles compared to those with wild type (TT) alleles especially in atopic asthmatic children, whereas there were no differences of those parameters in the normal controls. CONCLUSION: In Korean children with atopic asthma, a significant association was observed between the thromboxane A2 receptor (T924C) polymorphism and spirometric data such as FEV1 (%) and FEF25~75%(%). These results suggest that thromboxane A2 receptor polymorphism would be a disease- modifying gene in childhood asthma.

MeSH Terms

Alleles
Asthma*
Child*
Constriction
Genotype
Humans
Methacholine Chloride
Muscle, Smooth
Phenotype
Receptors, Thromboxane A2, Prostaglandin H2*
Thromboxane A2*
Methacholine Chloride
Receptors, Thromboxane A2, Prostaglandin H2
Thromboxane A2