Korean J Obstet Gynecol.
2004 Sep;47(9):1680-1683.
Thromboxane in Pregnancy-Induced Hypertension
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, College of Medicine, Konkuk University, Chung-Ju, Korea.
- 2Department of Laboratory Medicine, College of Medicine, Konkuk University, Chung-Ju, Korea.
- 3Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Chung-Ju, Korea.
Abstract
OBJECTIVE
High thromboxane level evidence supports pivotal involvement of TxA2 in pathophysiology of pregnancy induced hypertension and provides a strong rationale for pursuing TxA2-blocking strategies in drug development.
METHODS
The stable metabolites of TXA2 (Thromboxane B2) in maternal blood of 12 patients with mild preeclampsia, 4 patients with severe preeclampsia and 14 normal parturients were measured by competitive enzyme immunoassay.
RESULTS
TxB2 concentrations were not increased in mild preeclampsia (101 +/- 12 pg/mL, n=12) as compared with normal pregnancy (150 +/- 15 pg/mL, n=14), but they were significantly increased in severe preeclampsia (454 +/- 102 pg/mL, p<0.0001, n=4).
CONCLUSION
Maternal plasma thromboxane is increased only in severe preeclampsia. Thus, increased thromboxane A2 biosynthesis correlates with disease severity and may have a pathogenetic role in pregnancy-induced hypertension. These findings provide a rationale for the use of aspirin in the treatment as well as in the prevention of this disorder.
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