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Duloxetine-Induced Liver Injury in Patients with Major Depressive Disorder

Kang SG, Park YM, Lee HJ, Yoon B

  • KMID: 2316095
  • Psychiatry Investig.
  • 2011 Sep;8(3):269-271.
Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also...
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New oral anticoagulants

Oh S

The most important and widely-prescribed drug for anticoagulation is a vitamin K antagonist such as warfarin although it has several limitations in clinical use. New oral anticoagulants (NOACs) have been...
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Two Cases of Hyponatremia Induced by Duloxetine for Treating Peripheral Neuropathic Pain

Ra JE, Hwang IK, Seo BS, Lee JK, Mok YM, Kim H, Lee JE

  • KMID: 2264795
  • Korean J Med.
  • 2012 Dec;83(6):813-816.
Duloxetine is a balanced serotonin and norepinephrine reuptake inhibitor available for treating peripheral neuropathic pain. The occurrence of hyponatremia as an adverse event of duloxetine treatment, but it has not...
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Acute Dystonia after Using Single Dose Duloxetine: Case Report

Karakas Ugurlu G, Onen S, Bayindirli D, Caykoylu A

  • KMID: 2316253
  • Psychiatry Investig.
  • 2013 Mar;10(1):95-97.
Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor which is known to be effective in depression and anxiety disorders. The common adverse effects include dry mouth, nausea,...
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A Case of Serotonin Syndrome Induced by Fluoxetine and Duloxetine Independently in a Same Patient

You S, Noh JS

  • KMID: 2287474
  • Korean J Psychopharmacol.
  • 2012 Apr;23(2):74-77.
Here we report a case of serotonin syndrome caused by fluoxetine 20 mg and duloxetine 60 mg independently eight week apart. A 65-year old man developed fever, agitation and change...
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Effect of Duloxetine in Functional Gastrointestinal Disorder : In the Perspective of 'Brain-Gut Axis'

Lee SS, Park SS

  • KMID: 1985571
  • Korean J Psychosom Med.
  • 2012 Dec;20(2):135-138.
The pathophysiology of functional gastrointestinal disorder(FGID) is not completely understood, but the importance of the 'Brain-Gut Axis(BGA)' model in FGID is being increasingly recognized. The BGA model is a bidirectional,...
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Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide

Chun JS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC

Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic...
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Rapid-Onset Hyponatremia Induced by Duloxetine in a Middle-Aged Male with Depression and Somatic Symptoms

Choi JS, Lee HW, Lee JY, Jung HY

  • KMID: 2316166
  • Psychiatry Investig.
  • 2012 Mar;9(1):83-84.
Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine developed rapidly after starting the medication in a middle-aged male...
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Successful Prasugrel Rescue Therapy in Clopidogrel Resistant Patients Who Had Recurrent Stent Thrombosis of Drug-Eluting-Stent: The Role of Prasugrel in Clopidogrel Nonresponders

Lee SH, Kim BK, Oh J, Park JS, Lee DJ, Lee HC, Kim JH, Hong MK

Stent thrombosis is a very serious problem after drug-eluting stent (DES) implantation even though its incidence is about or less than 1%. As the clopidogrel resistance is expected to play...
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Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome Caused by Topical Ophthalmic Use of Dorzolamide

Kim JW, Shin SY

  • KMID: 2247975
  • Korean J Dermatol.
  • 2009 Mar;47(3):317-321.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the potentially life-threatening, acute hypersensitivity reaction to inciting drugs. These diseases have been often associated with systemic carbonic anhydrase inhibitor such...
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Comparison of Hematologic Changes between Rivaroxaban and Aspirin for Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty

Song MH, Kim BH, Ahn SJ, Yoo SH, Kim YJ

PURPOSE: To compare the hematologic changes and the rates of transfusion of patients using rivaroxaban or aspirin for venous thromboembolism prophylaxis after a total knee arthroplasty. MATERIALS AND METHODS: Among patients...
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Diagnosis and Treatment of Fibromyalgia Syndrome

Lee SS

  • KMID: 2267843
  • Korean J Med.
  • 2013 May;84(5):650-658.
Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and various accompanying symptoms including fatigue, sleep disturbances, and cognitive dysfunction. While the etiology of fibromyalgia is unclear, accumulating data suggest...
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Stroke Update 2011: New Antithrombotics

Seo KD, Lee KY

  • KMID: 2288709
  • Korean J Stroke.
  • 2012 Aug;14(2):62-66.
Several new antithrombotic drugs have been developed and approved to use in clinical practice recently. Dabigatran, a direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor, have been approved in...
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Medical Treatment of Atypical Femoral Fracture

Ha YC, Lee YK, Min BW

Unlike typical hip fractures, atypical femoral fractures occur at subtrochanteric or diaphyseal area. Characteritics of atypical femoral fractures include their location in the subtrochanteric region and femoral shaft, transverse or...
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New Oral Antiplatelet Agents

Kang MK, Chang K

  • KMID: 2267821
  • Korean J Med.
  • 2013 Jul;85(1):10-14.
Antiplatelet agents play an essential role in the treatment of acute coronary syndrome (ACS). Aspirin and thienopyridines comprise the major classes of antiplatelet therapies demonstrated to be of benefit in...
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Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder

Park YM, Lee BH, Lee HJ, Kang SG

  • KMID: 2315894
  • Psychiatry Investig.
  • 2010 Sep;7(3):228-230.
Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and...
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Long-Term Anticoagulation in the Extreme Elderly with the Newer Antithrombotics: Safe or Sorry?

Chiong JR, Cheung RJ

BACKGROUND AND OBJECTIVES: The prevalence of atrial fibrillation (AF) doubles in the extreme elderly and is higher than in the rest of the population. Warfarin therapy to prevent thromboembolic events...
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Roles of Serotonergic and Adrenergic Receptors in the Antinociception of Selective Cyclooxygenase-2 Inhibitor in the Rat Spinal Cord

Jeong HJ, Lee SH, Cho SY, Lee CS, Jeong CW, Yoon MH, Kim WM

BACKGROUND: The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic...
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Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice

Park CH, Shin TK, Lee HY, Kim SJ, Lee WS

The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia in mice. Male C57BL/6 mice were anesthetized,...
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Recent advances in the management of venous thromboembolism

Ageno W

Venous thromboembolism (VTE) is a spectrum of diseases that includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Anticoagulant treatment is the mainstay of therapy for VTE. Unfractionated heparin (UFH)...
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