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Congenital Double-Orifice Mitral Valve with Mitral Regurgitation due to Flail Leaflet in an Elderly Patient

Kim SJ, Shin ES, Lee SG

We report here on a case of double-orifice mitral valve with mitral regurgitation in a 75-year-old female who had complaints of mild dyspnea. Transthoracic and transesophageal echocardiography showed two orifices...
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Cutaneous Metastases of Pancreatic Carcinoma as a First Clinical Manifestation

Jun DW, Lee OY, Park CK, Choi HS, Yoon BC, Lee MH, Lee DH

Cutaneous metastases from pancreatic adenocarcinomas are rare lesions. The most common site of cutaneous metastasis is the umbilicus, and this is also known as the 'Sister Mary Joseph' nodule. A...
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Adult Onset Still's Disease as a Cause of Acute Severe Mitral and Aortic Regurgitation

Lee JS, Do IN, Kang DH, Joo SJ, Yoo B, Moon HB, Lee CK

Adult onset Still's disease (AOSD) is an uncommon acute systemic inflammatory disease of unknown origin. The clinical features include high spiking fever, arthralgia or arthritis, transient maculopapular rash, lymphadenopathy, hepatosplenomegaly,...
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Clear Cell Hepatocellular Carcinoma with Spontaneous Regression of Primary and Metastatic Lesions

Jeon SW, Lee MK, Lee YD, Seo HE, Cho CM, Tak WY, Kweon YO

The prognosis of advanced hepatocellular carcinoma (HCC) tends to be poor. Spontaneous regression of this lesion is extremely rare. In this report, we describe a case of HCC which spontaneously...
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A Case of Avascular Necrosis of the Femoral Head as Initial Presentation of Chronic Myelogenous Leukemia

Moon JY, Kim BS, Yun HR, Choi JH, Lee YY, Kim IS, Ahn MJ

Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hemopoietic stem cells characterized by abnormal proliferation and accumulation of immature granulocyte. Leukostasis is one of the complications of CML...
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Delayed Ventricular Septal Rupture after Percutaneous Coronary Intervention in Acute Myocardial Infarction

Park JY, Park SH, Oh JY, Kim IJ, Lee YH, Park SH, Kwon KH

In the era before reperfusion therapy, ventricular septal rupture complicated 1~3% of acute myocardial infarctions (AMI) usually 3-5 days after onset. Studies have reported a positive correlation between the incidence...
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A Case of Uterine Cervical Cancer Presenting with Granulocytosis

Ahn HJ, Park YH, Chang YH, Park SH, Kim MS, Ryoo BY, Yang SH

Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients...
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Expression of Cyclooxygenase-2 and Bcl-2 in Human Gastric Adenomas

Park JH, Kang KH, Kim SH, Lee JH, Cho CM, Kweon YO, Kim SK, Choi YH, Bae HI, Kim MS

BACKGROUND: Cyclooxygenase (COX) -2 is the rate-limiting enzyme in prostaglandin synthesis. An increased expression has been implicated in the development and progression of human gastric cancers and colorectal adenomas and...
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Clinicopathologic Significance of Gastric and Intestinal Phenotypic Marker Expression in Gastric Carcinomas

Kim GH, Song GA, Park DY, Lee DH, Kim TO, Lee SH, Heo J, Kang DH, Cho M

BACKGROUND: It is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal...
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High-dose Versus Low-dose Cyclophosphamide in Combination with G-CSF for Peripheral Blood Progenitor Cell Mobilization

Ahn JS, Park S, Im SA, Yoon SS, Lee JS, Kim BK, Bang SM, Cho EK, Lee JH, Jung CW, Kim HC, Seong CM, Lee MH, Kim CS, Lee KS, Lee JA, Ahn MJ

BACKGROUND: To compare the mobilizing effects and toxicities of two different doses of cyclophosphamide (CY) plus lenograstim (glycosylated G-CSF), we performed a prospective randomized study by enrolling patients suffering with...
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Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma

Oh JM, Kim SH, Suh CH, Nahm DH, Park HS, Lee YM, Lee JH, Park CS, Shin HD

BACKGROUND: Glutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val)...
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Effect of High-Dose Intravenous N-acetylcysteine on the Concentration of Plasma Sulfur-Containing Amino Acids

Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Lee EM, Hwang SK

BACKGROUND: The purpose of this study was to determine the adequate loading and maintenance doses of N-acetylcyseteine (NAC) for patients suffering from acute ROS-induced injury. METHODS: Concentrations of extra cellular...
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Irinotecan, Continuous 5-Fluorouracil, and Low dose of Leucovorin (modified FOLFIRI) as First Line of Therapy in Recurrent or Metastatic Colorectal Cancer

Lee MA, Byun JH, Shim BY, Woo IS, Kang JH, Hong YS, Lee KS, Choi MG, Chang SK, Oh ST, Choi SI, Lee DS

BACKGROUND: Irinotecan, in combination with 5-fluorouracil (5-FU) and a high dose of leucovorin (LV), known as FOLFIRI regimen, has shown activity in recurrent or metastatic colorectal cancer. Therefore, we evaluated...
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Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study

Ko OB, Kim S, Shim H, Lee JH, Ahn JM, Yoon SM, Jeon MH, Do IN, Lee SY, Kim YG, Kim SW, Kim SB, Kim SH, Lee JS, Kim W, Park CJ, Chi HS, Suh C

BACKGROUND: Although high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially...
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The Inverse Association Between the Presence of Antibody to Hepatitis B Surface Antigen and Atopy in Young Adults

Koh YI, Choi IS, Park CH, Ahn JS, Ji SG

BACKGROUND: Some bacterial and viral infections may reduce the risk of atopy, and this is based on the concept of their ability to divert the immune system towards the Th1...
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