Korean J Intern Med.  2005 Sep;20(3):247-250. 10.3904/kjim.2005.20.3.247.

A Case of Uterine Cervical Cancer Presenting with Granulocytosis

• Ahn HJ
• Park YH
• Chang YH
• Park SH
• Kim MS
• Ryoo BY
• Yang SH

• KMID: 1782238
• DOI: http://doi.org/10.3904/kjim.2005.20.3.247

Abstract

Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69, 000/micro L, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.

Keyword

Leukocytosis; Paraneoplastic syndrome; Cervical cancer

MeSH Terms

Uterine Neoplasms/complications/*diagnosis
Uterine Cervical Neoplasms/complications/*diagnosis/physiopathology
Paraneoplastic Syndromes/*etiology
Middle Aged
Leukocytosis/*etiology
Humans
Granulocytes/*pathology
Female