Obstet Gynecol Sci.  2013 Nov;56(6):420-425. 10.5468/ogs.2013.56.6.420.

Small cell neuroendocrine carcinoma of the uterine cervix presenting with syndrome of inappropriate antidiuretic hormone secretion

• Kim DY
• Yun HJ
• Lee YS
• Lee HN
• Kim CJ

• KMID: 1500379
• DOI: http://doi.org/10.5468/ogs.2013.56.6.420

Abstract

Small cell carcinoma of the uterine cervix is rare. It is estimated that 10% of patients with small-cell lung cancer have syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hyponatremia has been reported to be significantly associated with a poor prognosis. A proportion of small cell carcinoma of the uterine cervix exhibit neuroendocrine characteristics as revealed by immunohistochemistry, However, cases presenting typical symptoms due to SIADH are extremely rare. This report of the SIADH of the uterine cervix is a rare case in the small cell carcinoma of the cervix presenting with tumor-associated paraneoplastic syndrome.

Keyword

Cervical cancer; Small cell carcinoma; Syndrome of inappropriate antidiuretic hormone secretion

MeSH Terms

Carcinoma, Neuroendocrine*
Carcinoma, Small Cell*
Cervix Uteri
Female
Humans
Hyponatremia
Immunohistochemistry
Inappropriate ADH Syndrome*
Lung Neoplasms
Paraneoplastic Syndromes
Prognosis
Rare Diseases
Uterine Cervical Neoplasms*

Figure

• 

  Fig. 1 (A) Axial magnetic resonance image showing loss of majority of normal cervical stromal hyposignal intensity on T2-weighted imaging is seen around the above mass. Irregular an spiculated margin of the mass is noted. (B) Axial magnetic resonance image showing metastatic lymph node along the both iliac chains.

• 

  Fig. 2 Photomicrograph of the cervical tumor (A, B). Note that the cells are small in size with hyperchromatic round nuclei and scanty cystoplasm (A, H&E, ×40; B, H&E, ×200). (C) Parametrial Invasion but less then 0.1 cm (H&E, ×40). (D) Myometrial invasion (H&E, ×40). (E) Both external iliac lymph nodes showing metastasis (H&E, ×200). (F) Immunohistochemical staining for chromogranin (Immunohistochemistry for chromogranin, ×200).

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