Soonchunhyang Med Sci.  2014 Dec;20(2):108-111. 10.0000/sms.2014.20.2.108.

A Case of Mixed Small and Large Cell Neuroendocrine Carcinoma of the Uterine Cervix

• Ryu A
• Mun ST
• Kim SS

• KMID: 2317734
• DOI: http://doi.org/10.0000/sms.2014.20.2.108

Abstract

A rare case of mixed carcinoma of the cervix is reported, composed of a small and large cell neuroendocrine carcinoma. Neuroendocrine cervical carcinomas are very rare and aggressive. The prognosis is very poor despite multimodal treatment. Earlier reports have shown that the majority of patients present with advanced stage disease, have lymph node metastasis, and are at a high risk for recurrence and disease progression. In this study, we report the case of a 26-year-old woman with composite small and large cell neuroendocrine carcinoma of the cervix. A woman presented with vaginal bleed since 2 months of presentation. Gynecologic examination revealed cervical enlargement, and punch biopsy of the cervical lesion was performed. The biopsy was disclosed a large cell neuroendocrine carcinoma. The patient underwent a radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection. The final histopathologic findings are mixed small and large cell neuroendocrine carcinoma of cervix.

Keyword

Uterine cervical neoplasms; Neuroendocrine carcinoma; Small cell carcinoma cervix; Large cell neuroendocrine carcinoma

MeSH Terms

Adult
Biopsy
Carcinoma, Neuroendocrine*
Cervix Uteri*
Combined Modality Therapy
Disease Progression
Female
Humans
Hysterectomy
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis
Prognosis
Recurrence
Uterine Cervical Neoplasms