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The effect of thalidomide on visceral fat pad mass and triglyceride concentration of the skeletal muscles in rats

Kim KH, Choi CB, Kim JY

BACKGROUND: Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle...
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A Case of Amyloidosis Presenting as Lymphadenopathy at the Porta Hepatis

Lee JI, Kim JS, Kim BW

We report a rare case of systemic amyloidosis with gastrointestinal and lymph node involvement. A 64-year-old woman was admitted to our hospital with dyspepsia and weight loss. Initial esophagogastroduodenoscopy (EGD)...
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Necessity of Research for Safe Drug use in Pregnant Women

Han JY, Cho GJ, Oh JM

The thalidomide tragedy in the 1960s has resulted in a perpetuation of a certain perception amongst physicians and pregnant women that the use of medication during pregnancy is a potential...
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Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus

Muñoz-Pérez VM, Fernández-Martínez E, Ponce-Monter H, Ortiz MI

The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats...
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Therapeutic effect of the immunomodulatory drug lenalidomide, but not pomalidomide, in experimental models of rheumatoid arthritis and inflammatory bowel disease

Lopez-Millan B, Diaz de la Guardia R, Roca-Ho H, García-Herrero CM, Lavoie JR, Rosu-Myles M, Gonzalez-Rey E, O'Valle F, Criado G, Delgado M, Menendez P

Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide...
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POEMS syndrome misdiagnosed as bone metastasis in a patient with thyroid cancer

Baek SA, Ryoo HM, Bae SH, Cho YY, Kim SG, Kim GY, Kim MK

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a monoclonal plasma cell disorder. Patients with POEMS syndrome also have various clinical manifestations including generalized edema, pleural effusion,...
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Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-beta1

Lv P, Meng Q, Liu J, Wang C

PURPOSE: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis. In this study, the effect of thalidomide on the...
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The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea

Kim C, Lee HS, Min CK, Lee JJ, Kim K, Yoon DH, Eom HS, Lee H, Lee WS, Shin HJ, Lee JH, Park Y, Jo JC, Do YR, Mun YC

BACKGROUND/AIMS: The purpose of this study was to determine the correlations between inflammatory factors-including absolute lymphocyte count, lactate dehydrogenase, beta2-microglobulin, albumin, C-reactive protein, and ferritin-and the prognosis for survival in...
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Pharmacologic Therapy for Cancer Anorexia-Cachexia Syndrome

Yoon S, Kim H

Cancer-related anorexia-cachexia syndrome (CACS) is a hypercatabolic state, characterized by reduced appetite and weight loss due to ongoing loss of skeletal muscle mass and adipose tissue. CACS occurs mainly in...
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Primary Amyloidosis with Involvement of Stomach, Duodenum and Colon

Kim IK, Lee JS, Mun JK, Choi MS, Ha JH, Jeong MY, Seo JH, Cheung DY, Kim JI

We report the case of a 57-year-old woman with abdominal discomfort. The patient had anemia and hypoalbuminemia. Esophagogastroduodenoscopy and colonoscopy revealed diffuse infiltrative lesions at the stomach, duodenum, and ascending...
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Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

Park SY, Moon HS, Seong JK, Jeong HY, Yoon BY, Hwang SW, Song KS

We report a rare case of a gastric plasmacytoma treated with endoscopic resection and oral thalidomide therapy. A 70-year-old man was admitted to our hospital with indigestion. He had no...
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Update on the Treatment of Intestinal Behcet's Disease

Kim KJ

Behcet's disease is a chronic relapsing disease with unknown etiology, involving the multiorgan system characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmologic, neurologic, or gastrointestinal manifestations (or...
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Gangrenous Cryoglobulinemic Vasculitis in a Patient with Multiple Myeloma

Ryu H, Park B, Moon JY, Lee MW, Choi YS, Song IC, Jo DY

  • KMID: 2267752
  • Korean J Med.
  • 2013 Dec;85(6):634-638.
We report a 62-year-old woman with multiple myeloma associated with cryoglobulinemia accompanied by gangrene of the digits. She presented with generalized purplish net-like discoloration (livedo reticularis), which was more prominent...
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Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain

Lee HG, Kim WM, Yoon MH, Park AR, Choi JI

BACKGROUND: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which...
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The impact of novel therapeutic agents before and after frontline autologous stem cell transplantation in patients with multiple myeloma

Min CK, Lee SE, Yahng SA, Cho BS, Eom KS, Kim YJ, Kim HJ, Lee S, Cho SG, Kim DW, Lee JW, Min WS, Park CW

BACKGROUND: Novel agents (NAs) such as thalidomide and bortezomib have been administered in combination with autologous stem-cell transplantation (ASCT) to effectively treat multiple myeloma (MM). However, whether NAs perform better...
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Diagnosis and therapy of multiple myeloma

Palumbo A, Cerrato C

Many advances in the treatment of multiple myeloma have been made due to the use of transplantation and the introduction of novel agents including thalidomide, lenalidomide, and bortezomib. The first...
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A Combination of Melphalan, Prednisone, and 50 mg Thalidomide Treatment in Non-Transplant-Candidate Patients with Newly Diagnosed Multiple Myeloma

Chang HJ, Lee JH, Do YR, Bae SH, Lee JL, Nam SH, Yoon SS, Bang SM

BACKGROUND/AIMS: The clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as...
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Is the Low-Thalidomide Dose MPT Regimen Beneficial?

Min CK

No abstract available.
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Treatment of chronic graft-versus-host disease: Past, present and future

Martin PJ, Inamoto Y, Carpenter , Lee SJ, Flowers ME

Chronic GVHD was recognized as a complication of allogeneic hematopoietic cell transplantation more than 30 years ago, but progress has been slowed by the limited insight into the pathogenesis of...
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Variant Burkitt-type translocation (8;22)(q24;q11) in plasma cell myeloma

Kim H, Moon HW, Hur M, Yun YM, Park CM, Lee MH

Variant Burkitt-type translocation, t(8;22)(q24;q11), is very rare in plasma cell myeloma. We report a 51-year-old male patient with plasma cell myeloma, who showed t(8;22) (q24;q11). He suffered from pelvic pain...
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