- Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1)
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Kim KS, Shin DH, Nam JH, Park KS, Zhang YH, Kim WK, Kim SJ
- KMID: 2071715
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):419-425.
- doi: 10.4196/kjpp.2010.14.6.419
Mast cells are activated by specific allergens and also by various nonspecific stimuli, which might induce physical urticaria. This study investigated the functional expression of temperature sensitive transient receptor potential... -
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- Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene
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Choi JY, Kim SE, Lee SE, Kim SC
- KMID: 2418801
- Yonsei Med J.
- 2018 Mar;59(2):341-344.
- doi: 10.3349/ymj.2018.59.2.341
Olmsted syndrome (OS) is a rare congenital skin disorder characterized by severe palmoplantar and periorificial keratoderma, alopecia, onychodystrophy, and severe pruritus. Recently, pathogenic ‘gain-of-function‘ mutations of the transient receptor potential... -
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- Expression of Calcium Transporters According to Dietary Sodium in the Distal Tubule of Rat Kidneys
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Heo NJ, Kim HS, Lee JH, Jang HR, Kim SJ, Oh YK, Na KY, Joo KW, Han JS
- KMID: 2079742
- Korean J Nephrol.
- 2007 Jul;26(4):390-397.
PURPOSE: Hypercalciuria is a risk factor of renal calcium stone and proper initial management is dietary salt restriction. But the molecular mechanism responsible for this sodium calcium relationship remains unclear.... -
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- Kidney and Calcium Homeostasis
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Jeon US
- KMID: 2134808
- Electrolyte Blood Press.
- 2008 Dec;6(2):68-76.
- doi: 10.5049/EBP.2008.6.2.68
Plasma calcium concentration is maintained within a narrow range (8.5-10.5 mg/dL) by the coordinated action of parathyroid hormone (PTH), 1,25(OH)2D3, calcitonin, and ionized calcium (iCa2+) itself. The kidney plays a... -
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- The Effect of DA-5018, A Synthetic Capsaicin Derivative,on Voltage-Dependent Calcium Currents in TrigeminalGanglion Neurons of Neonatal Rats
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Kim JS
- KMID: 1883692
- Chonnam Med J.
- 2007 Dec;43(3):158-167.
Capsaicin is known to produce initial excitation followed by desensitization to various stimuli on the sensory neurons. The aim of this study was to investigate the electrophysiological characteristics of voltage-dependent... -
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- Neonatal Bladder Irritation Is Associated With Vanilloid Receptor TRPV1 Expression in Adult Rats
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Park JS, Jung HD, Cho YS, Jin MH, Hong CH
- KMID: 2422504
- Int Neurourol J.
- 2018 Sep;22(3):169-176.
- doi: 10.5213/inj.1836020.101
PURPOSE: To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats. METHODS:... -
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- Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability
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Lee JH, Park C, Kim SJ, Kim HJ, Oh GS, Shen A, So HS, Park R
- KMID: 2154231
- Exp Mol Med.
- 2013 Mar;45(3):e12.
Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient... -
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- Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation
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Kang SS, Shin SH, Auh CK, Chun J
- KMID: 1402315
- Exp Mol Med.
- 2012 Dec;44(12):707-722.
The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues where it participates in the generation... -
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- Differential Effect of Capsaicin on the Cell Death in Primary Cultured Neurons
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Lee WT, Lee JH, Lee SH, Park KA, Lee JE
- KMID: 2030752
- Korean J Anat.
- 2002 Apr;35(2):161-171.
Capsaicin, the pungent algesic substance of the red pepper is known to be a neurotoxic substance, interrupting the pain conducting pathway. The neurotoxic effects of capsaicin to adult animals were... -
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- Are Rice and Spicy Diet Good for Functional Gastrointestinal Disorders?
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Gonlachanvit S
- KMID: 2326134
- J Neurogastroenterol Motil.
- 2010 Apr;16(2):131-138.
Rice- and chili-containing foods are common in Asia. Studies suggest that rice is completely absorbed in the small bowel, produces little intestinal gas and has a low allergenicity. Several clinical... -
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- Increase of TRPV1-Immunoreactivity in Dorsal Root Ganglia Neurons Innervating the Femur in a Rat Model of Osteoporosis
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Yoshino K, Suzuki M, Kawarai Y, Sakuma Y, Inoue G, Orita S, Yamauchi K, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Toyone T, Takahashi , Ohtori S
- KMID: 2070208
- Yonsei Med J.
- 2014 Nov;55(6):1600-1605.
- doi: 10.3349/ymj.2014.55.6.1600
PURPOSE: Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli. Recently, an association between bone pain and... -
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- Transient Receptor Potential Vanilloid 1-Immunoreactive Innervation Increases in Fractured Rat Femur
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Kawarai Y, Suzuki M, Yoshino K, Inoue G, Orita S, Yamauchi K, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Takaso M, Toyone T, Takahashi , Ohtori S
- KMID: 1779904
- Yonsei Med J.
- 2014 Jan;55(1):185-190.
- doi: 10.3349/ymj.2014.55.1.185
PURPOSE: Pain from vertebral or femoral neck fractures is a particularly important problem in clinical orthopaedics. Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, and there... -
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- Viewpoints on Acid-Induced Inflammatory Mediators in Esophageal Mucosa
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Harnett KM, Rieder F, Behar J, Biancani P
- KMID: 2204233
- J Neurogastroenterol Motil.
- 2010 Oct;16(4):374-388.
We have focused on understanding the onset of gastroesophageal reflux disease by examining the mucosal response to the presence of acid in the esophageal lumen. Upon exposure to HCl, inflammation... -
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- Effects of Thiazide on the Expression of TRPV5, Calbindin-D28K, and Sodium Transporters in Hypercalciuric Rats
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Jang HR, Kim S, Heo NJ, Lee JH, Kim HS, Nielsen S, Jeon US, Oh YK, Na KY, Joo KW, Han JS
- KMID: 1778157
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S161-S169.
- doi: 10.3346/jkms.2009.24.S1.S161
TRPV5 is believed to play an important role in the regulation of urinary calcium excretion. We assessed the effects of hydrochlorothiazide (HCTZ) on the expression of TRPV5, calbindin-D28K, and several... -
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- High Dose Vitamin D3 Attenuates the Hypocalciuric Effect of Thiazide in Hypercalciuric Rats
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Jang HR, Lee JW, Kim S, Heo NJ, Lee JH, Kim HS, Jung JY, Oh YK, Na KY, Han JS, Joo KW
- KMID: 1785909
- J Korean Med Sci.
- 2010 Sep;25(9):1305-1312.
- doi: 10.3346/jkms.2010.25.9.1305
Thiazide is known to decrease urinary calcium excretion. We hypothesized that thiazide shows different hypocalciuric effects depending on the stimuli causing hypercalciuria. The hypocalciuric effect of hydrochlorothiazide (HCTZ) and the... -
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