- Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer
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Lee SS, Cho KJ, Hong SI, Myoung NK, Jang JJ
- KMID: 1064962
- J Korean Med Sci.
- 1998 Apr;13(2):153-158.
- doi: 10.3346/jkms.1998.13.2.153
We unexpectedly observed strong nuclear overexpression of bcl-2 protein in advanced stomach cancer. As far as we know, such expression has not yet been reported. To investigate the significance... -
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- Distribution of 5-Fluorouracil-14C in Body Tissues after Systemic and Regional Administration in Gastric Cancer
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Min JS, Ban JM, Kim MW, Kim CK, Ryu KJ
- KMID: 693031
- Yonsei Med J.
- 1986 Sep;27(3):200-204.
- doi: 10.3349/ymj.1986.27.3.200
This study was to determine which of two routes of administration of 5-fluorouracil (5-FU) is more effective, by measuring the radioactvity in the body tissues of gastric cancer patients after... -
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- Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma
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Jang SJ, Ahn MJ, Paik SS, Kong G, Keum JS, Park YW, Lee JD
- KMID: 1038163
- J Korean Med Sci.
- 1998 Aug;13(4):369-376.
- doi: 10.3346/jkms.1998.13.4.369
Evidence suggests that multiple molecular events, including alteration of cell cycle regulators are involved in the development and progression of gastric carcinoma. Recently, it has been reported that the... -
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- Expression of eosinophil chemotactic factors in stomach cancer
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Hong SW, Cho MY, Park C
- KMID: 711626
- Yonsei Med J.
- 1999 Apr;40(2):131-136.
- doi: 10.3349/ymj.1999.40.2.131
We have occasionally experienced eosinophilic abscess of the liver in patients with gastric carcinoma, suggesting that some eosinophil mobilizing (chemotactic and proliferative) factors might be produced by carcinoma... -
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- Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer
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Ko BK, Cho HR, Choi DW, Nam CW, Park CJ, Kim GY, Kim SS, Woo YJ, Huh J, Kim MY
- KMID: 1745551
- J Korean Med Sci.
- 1998 Jun;13(3):286-290.
- doi: 10.3346/jkms.1998.13.3.286
The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes and their... -
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- p21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP
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Park YE, Choi KC, Choi YH
- KMID: 645210
- J Korean Med Sci.
- 1998 Oct;13(5):507-512.
- doi: 10.3346/jkms.1998.13.5.507
p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a... -
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- Prognostic significance of E-cadherin/catenin complex expression in gastric cancer
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Joo YE, Park CS, Kim HS, Choi SK, Rew JS, Kim SJ
- KMID: 2157546
- J Korean Med Sci.
- 2000 Dec;15(6):655-666.
- doi: 10.3346/jkms.2000.15.6.655
Abnormal expression of E-cadherin/catenin complex in cancer has been associated with poor differentiation and acquisition of invasiveness, suggesting a possible role of this protein as an invasion suppressor. In this... -
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- Fatty acid patterns in gastric mucosa of stomach cancer patients
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Ahn J, Park IS, Lee KS, Kim SY, Chung EJ, Kim J, Kim DJ, Yoon S, Lee-Kim YC
- KMID: 720612
- Yonsei Med J.
- 2001 Apr;42(2):220-226.
- doi: 10.3349/ymj.2001.42.2.220
omega6 and omega3 fatty acids are important cellular components and known to be involved in disease processes. However, few studies have focused on mucosa fatty acid in... -
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- Expression of MAGE-1, -2, and -3 genes in gastric carcinomas and cancer cell lines derived from Korean patients
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Kim YM, Lee YH, Shin SH, Kim EH, Choi YW, Lee KM, Park JH, Lee YU, Seel DJ, Kim MC
- KMID: 1066496
- J Korean Med Sci.
- 2001 Feb;16(1):62-68.
- doi: 10.3346/jkms.2001.16.1.62
We investigated the expression of MAGE-1, -2, and -3 genes in tissues of 51 gastric carcinomas from Korean patients and in 11 gastric cancer cell lines established in Korea using... -
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- Clinicopathologic characteristics of mucinous gastric adenocarcinoma
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Hyung WJ, Noh SH, Shin DW, Yoo CH, Kim CB, Min JS, Lee KS
- KMID: 711621
- Yonsei Med J.
- 1999 Apr;40(2):99-106.
- doi: 10.3349/ymj.1999.40.2.99
There has been considerable controversy over the prognosis of mucinous gastric enocarcinoma (MGC). In this study we analyzed the clinicopathologic fferences between MGC and non-mucinous gastric carcinoma (NMGC).... -
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- Primary malignant lymphomas of the stomach. Pathological and clinical analyses of 38 resected cases
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Kang YK, Kim CW, Kim WH, Jang JJ, Park SH, Kim YI
- KMID: 645011
- J Korean Med Sci.
- 1996 Dec;11(6):480-488.
- doi: 10.3346/jkms.1996.11.6.480
The stomach is the most frequent site of extranodal lymphoma and primary gastric lymphoma might be distinguished from the nodal lymphoma by its different pathogenesis and prognosis. Based on the... -
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- Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
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Shin JY, Kim HS, Lee KS, Kim JB, Park JB, Won MH, Chae SW, Choi YH, Choi KC, Park YE, Lee JY
- KMID: 1109306
- Exp Mol Med.
- 2000 Jun;32(2):79-83.
Cyclin-dependent kinase inhibitors (CDKI) are negative regulators of cell cycle progression by binding the cyclin-CDK complex and inhibiting the CDK activity. Genetic alteration in the CDKI genes has been implicated... -
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- Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance
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Ahn MJ, Kim BH, Jang SJ, Hong EK, Lee WM, Baik HK, Park HK, Lee CB, Ki M
- KMID: 645211
- J Korean Med Sci.
- 1998 Oct;13(5):513-518.
- doi: 10.3346/jkms.1998.13.5.513
Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent... -
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- Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death
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Choi SC, Yoon SR, Park YP, Song EY, Kim JW, Kim WH, Yang Y, Lim JS, Lee HG
- KMID: 1091065
- Exp Mol Med.
- 2007 Dec;39(6):705-714.
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this gene has not been elucidated. In the present study, we... -
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- Expression of Peroxisome Proliferator-activated Receptor (PPAR)gamma in Helicobacter pylori-infected Gastric Epithelium
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Son SH, Kim HK, Ji JS, Cho YS, Kim SS, Chae HS, Choi MG, Han SW, Choi KY, Chung IS, Shin OR
- KMID: 935182
- Korean J Gastroenterol.
- 2007 Feb;49(2):72-78.
BACKGROUND/AIMS: Peroxisome proliferator-activated receptorgamma (PPARgamma), a nuclear transcription factor, plays a critical role in the regulation of gene expression associated with inflammation and cancer. PPARgamma is expressed in human gastric... -
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- Transforming growth factor beta 1 expression in gastric carcinoma
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Park YE, Choi YH, Lee WY, Choi KC
- KMID: 1038392
- J Korean Med Sci.
- 1997 Jun;12(3):215-220.
- doi: 10.3346/jkms.1997.12.3.215
Many types of human malignant tumor have been reported to amplify transforming growth factor-beta 1 (TGF-beta 1) gene and overexpress its protein. However, little work has been... -
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- Prostaglandin E2 and Interleukin-1beta Reduce E-cadherin Expression by Enhancing Snail Expression in Gastric Cancer Cells
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Jee YS, Jang TJ, Jung KH
- KMID: 1782129
- J Korean Med Sci.
- 2012 Sep;27(9):987-992.
- doi: 10.3346/jkms.2012.27.9.987
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) on E-cadherin expression in SNU719... -
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- Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer
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Lee MA, Hong YS, Kang JH, Lee KS, You JY, Lee KY, Park CH
- KMID: 759684
- Korean J Intern Med.
- 2004 Mar;19(1):43-47.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently, some gastric cancer cells were observed to contain the EBV sequence. We detected EBV in gastric... -
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- P53 overexpression in gastric adenocarcinoma with Helicobacter pylori infection
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Chang KH, Kwon JW, Kim BS, Hwang JH, Lee SK, Lee YC, Park HJ, Park IS, Kim HK
- KMID: 699939
- Yonsei Med J.
- 1997 Apr;38(2):117-124.
- doi: 10.3349/ymj.1997.38.2.117
Gastric carcinogenesis has been studied in various aspects. Helicobacter pylori (Hp) infection and mutation of the p53 tumor suppressor gene have recently been argued to be important factors... -
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- Effect of Helicobacter pylori on Gastric Epithelial Cell Kinetics and Expression of Apoptosis-related Proteins in Gastric Carcinogenesis
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Lee KM, Lee DS, Yang JM, Ahn BM, Lee EH, Yoo JY, Kim YJ, Chung IS, Sun HS, Park DH
- KMID: 772516
- Korean J Gastroenterol.
- 2003 Jul;42(1):12-19.
BACKGROUND/AIMS: We investigated apoptosis, cell proliferation and the expression of apoptosis-related proteins in the gastric epithelial cells of Helicobacter pylori (H. pylori)-negative and positive patients. METHODS: TUNEL staining, immunohistochemical... -
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