- Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
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Kim JR, Kim SY, Kim MJ, Kim JH
- KMID: 754996
- Exp Mol Med.
- 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers.... -
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- Hamartomatous gastric polyposis in a patient with tuberous sclerosis
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Kim BK, Kim YI, Kim WH
- KMID: 1730648
- J Korean Med Sci.
- 2000 Aug;15(4):467-470.
- doi: 10.3346/jkms.2000.15.4.467
A 42-year-old female diagnosed with tuberous sclerosis was found to have multiple polyps in the fundus of stomach. On histologic examination, the lesions were hamartomatous polyps. In tuberous sclerosis, many... -
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- DNA ploidy patterns in gastric adenocarcinoma
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Kim JY, Cho HJ
- KMID: 648117
- J Korean Med Sci.
- 2000 Apr;15(2):159-166.
- doi: 10.3346/jkms.2000.15.2.159
To assess the value of DNA ploidy, flow cytometric analysis was performed on unfixed fresh materials obtained from 86 patients with gastric cancer who underwent stomach resection. We evaluated the... -
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- Molecular genetic characterization of alternatively spliced CD44 transcripts in human stomach carcinoma
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Kim YS, Chi SG, Kim YW, Park YK, Yoon C
- KMID: 645110
- J Korean Med Sci.
- 1997 Dec;12(6):505-513.
- doi: 10.3346/jkms.1997.12.6.505
CD44 is a member of cell surface glycoproteins which are involved in cell-matrix adhesion and tumor metastasis. Certain types of tumors express complex CD44 isoforms generated by alternative splicing... -
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- The mechanism of c-erbB-2 gene product increase in stomach cancer cell lines
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Bae CD, Park SE, Seong YS, Kim SW, park JB, Park JG
- KMID: 1421967
- J Korean Med Sci.
- 1993 Apr;8(2):153-159.
- doi: 10.3346/jkms.1993.8.2.153
c-erbB-2 oncogene encodes a growth factor receptor whose amino acid sequence has extensive homology with human epidermal growth factor receptor. It is frequently overexpressed in human breast, ovary, lung, and... -
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- Role of the nm23-H1 gene in the metastasis of gastric cancer
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Hwang BG, Park IC, Park MJ, Moon NM, Choi DW, Hong WS, Lee SH, Hong SI
- KMID: 645111
- J Korean Med Sci.
- 1997 Dec;12(6):514-518.
- doi: 10.3346/jkms.1997.12.6.514
The nm23 gene is now generally accepted as one of the suppressor genes for metastasis in many types of human cancer. To investigate the role of the nm23 gene... -
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- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers
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Hong SJ, Oh JH, Jung YC, Kim YH, Kim SJ, Kang SJ, Seo EJ, Choi SW, Kang MI, Rhyu MG
- KMID: 1778036
- J Korean Med Sci.
- 2010 Mar;25(3):405-417.
- doi: 10.3346/jkms.2010.25.3.405
Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy... -
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- Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm
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Yoon H, Kim N, Shin CM, Lee HS, Kim BK, Kang GH, Kim JM, Kim JS, Lee DH, Jung HC
- KMID: 2363967
- Gut Liver.
- 2016 Mar;10(2):228-236.
- doi: 10.5009/gnl14472
BACKGROUND/AIMS: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. METHODS: We prospectively collected clinicopathologic data and measured the methylation... -
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- Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells
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Bae CD, Juhnn YS, Park JB
- KMID: 755111
- Exp Mol Med.
- 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the... -
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- Amplification of c-erbB-2 proto-oncogene in cancer foci, adjacent normal, metastatic and normal tissues of human primary gastric adenocarcinomas
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Kim JS, Choi CW, Kim BS, Shin SW, Kim YH, Mok YJ, Kim JS, Koo BH
- KMID: 1081052
- J Korean Med Sci.
- 1997 Aug;12(4):311-315.
- doi: 10.3346/jkms.1997.12.4.311
Genetic damages are frequently found in both tumor and normal cells at carcinogen exposed areas in the patients with upper aerodigestive tract cancer. These phenomena are explained by the... -
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- Genetic Alterations in Primary Gastric Carcinomas Correlated with Clinicopathological Variables by Array Comparative Genomic Hybridization
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Kang JU, Kang JJ, Kwon KC, Park JW, Jeong TE, Noh SM, Koo SH
- KMID: 2157817
- J Korean Med Sci.
- 2006 Aug;21(4):656-665.
- doi: 10.3346/jkms.2006.21.4.656
Genetic alterations have been recognized as an important event in the carcinogenesis of gastric cancer (GC). We conducted high resolution bacterial artificial chromosome array-comparative genomic hybridization, to elucidate in more... -
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- Prognostic Significance of p21 and p53 Expression in Gastric Cancer
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Seo YH, Joo YE, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1106143
- Korean J Intern Med.
- 2003 Jun;18(2):98-103.
BACKGROUND: Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of... -
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- Clinicopathologic Significance of Gastric and Intestinal Phenotypic Marker Expression in Gastric Carcinomas
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Kim GH, Song GA, Park DY, Lee DH, Kim TO, Lee SH, Heo J, Kang DH, Cho M
- KMID: 1782229
- Korean J Intern Med.
- 2005 Sep;20(3):191-197.
- doi: 10.3904/kjim.2005.20.3.191
BACKGROUND: It is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal... -
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- Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
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Shin JY, Kim HS, Lee KS, Kim JB, Park JB, Won MH, Chae SW, Choi YH, Choi KC, Park YE, Lee JY
- KMID: 1109306
- Exp Mol Med.
- 2000 Jun;32(2):79-83.
Cyclin-dependent kinase inhibitors (CDKI) are negative regulators of cell cycle progression by binding the cyclin-CDK complex and inhibiting the CDK activity. Genetic alteration in the CDKI genes has been implicated... -
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- Genetic events underlying morphological complexity of gastric carcinoma
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Rhyu MG
- KMID: 1038159
- J Korean Med Sci.
- 1998 Aug;13(4):339-349.
- doi: 10.3346/jkms.1998.13.4.339
Cancer is a genetic disorder in which gene alterations are selected to provide growth advantage by oncogene activation and/or tumor suppressor gene inactivation. Even marked intra-tumor variation in the... -
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- Microsatellite instability in Korean patients with gastric adenocarcinoma
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Jee MS, Koo C, Kim MH, Choi C, Lee KM, Choi SK, Rew JS, Yoon CM
- KMID: 1051579
- Korean J Intern Med.
- 1997 Jun;12(2):144-154.
OBJECTIVES: Microsatellites are short repeated oligonucleotide sequences found throughout the human genome. High mutation rates in microsatellite sequences have been found in tumors from patients with hereditary non-polyposis colorectal carcinoma... -
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- Continuous hypoxia attenuates paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line
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Kim H, Lee SW, Baek KM, Park JS, Min JH
- KMID: 1022125
- Exp Mol Med.
- 2011 Sep;43(9):494-500.
- doi: 10.3858/emm.2011.43.9.056
Paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride; PQ), an effective and widely used herbicide, was commercially introduced in 1962. It is reduced by the electron donor NADPH, and then reduced PQ transfers the electrons... -
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- Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma
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Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES
- KMID: 1775922
- Korean J Gastroenterol.
- 2010 Jan;55(1):19-25.
- doi: 10.4166/kjg.2010.55.1.19
BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such... -
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- Secretion of Biologically Active Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor by Transduced Gastric Cancer Cells
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Kim HY, Park GS, Shin HJ, Park S, Kim K, Kim HI
- KMID: 1084502
- Yonsei Med J.
- 2008 Apr;49(2):279-287.
- doi: 10.3349/ymj.2008.49.2.279
PURPOSE: Gastric cancer has the highest incidence rate among cancers in Asia. The advanced type of signet ring cell carcinoma has poor prognosis compared to other types of gastric cancer.... -
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