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Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions

Kim SI, Kim SJ, Suh DH, Kim K, No JH, Kim YB

OBJECTIVE: To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs). METHODS: We retrospectively identified...
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The efficacy of modified Swede Colposcopic Index in prediction of high-grade lesion and cancer of cervix

Rodpenpear N, Pataradool K

OBJECTIVE: To evaluate the efficacy of modified Swede Colposcopic Index (MSCI) to predict high-grade lesion and cancer of cervix (CIN2+, cervical intraepithelial neoplasia grade 2 or worse) in women with...
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Risk of cervical dysplasia among human papillomavirus-infected women in Korea: a multicenter prospective study

Park Y, Kim TJ, Hwang CS, Cho CH, Jeong DH, Seong SJ, Lee JK, Hur S, Kee MK, Seong J, Ki M

OBJECTIVE: Human papillomavirus (HPV) infection is the most important risk factor for cervical cancer, which progresses from precursor lesions with no symptom if left untreated. We compared the risk of...
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Cytomorphological Features of Hyperchromatic Crowded Groups in Liquid-Based Cervicovaginal Cytology: A Single Institutional Experience

Lee Y, Lee C, Park IA, An HJ, Kim H

BACKGROUND: Hyperchromatic crowed groups (HCGs) are defined as three-dimensional aggregates of crowded cells with hyperchromatic nuclei, and are frequently encountered in cervicovaginal liquid-based cytology (LBC). Here, we aimed to examine...
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Diagnostic Test Accuracy Review of Cytology for Squamous Intraepithelial Lesion and Squamous Cell Carcinoma of Uterine Cervix

Pyo JS, Kang G, Yoon HK, Kim HJ

BACKGROUND: Even though cervico-vaginal smears have been used as a primary screening test for cervical carcinoma, the diagnostic accuracy has been controversial. The present study aimed to evaluate the diagnostic...
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Burden of cervical neoplasia in mid-western rural Nepal: a population-based study

Thapa N, Shrestha G, Maharjan M, Lindell D, Maskey N, Shah R, Ge C, Cai H

OBJECTIVE: To assess the burden of cervical neoplasia in mid-western rural, Nepal using cytology, visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI). METHOD: A cross-sectional, population-based...
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Clinical factors that affect diagnostic discrepancy between colposcopically directed biopsies and loop electrosurgical excision procedure conization of the uterine cervix

Jung Y, Lee AR, Lee SJ, Lee YS, Park DC, Park EK

OBJECTIVE: This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP). METHODS: Between 2004 and 2016, 1,200...
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E2/E6 ratio and L1 immunoreactivity as biomarkers to determine HPV16-positive high-grade squamous intraepithelial lesions (CIN2 and 3) and cervical squamous cell carcinoma

Choi YJ, Lee A, Kim TJ, Jin HT, Seo YB, Park JS, Lee SJ

OBJECTIVE: Human papillomavirus (HPV) 16 is the most carcinogenic HPV genotype. We investigated if HPV16 L1 capsid protein and E2/E6 ratio, evaluated by cervical cytology, may be used as biomarkers...
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Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort

So KA, Kim SA, Lee YK, Lee IH, Lee KH, Rhee JE, Kee MK, Cho CH, Hong SR, Hwang CS, Jeong MS, Kim KT, Ki M, Hur SY, Park JS, Kim TJ

OBJECTIVE: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We analyzed...
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Are vaginal swabs comparable to cervical smears for human papillomavirus DNA testing?

Coorevits , Traen A, Bingé L, Van Dorpe , Praet M, Boelens J, Padalko E

OBJECTIVE: Human papillomavirus (HPV) testing is widely incorporated into cervical cancer screening strategies. Current screening requires pelvic examination for cervical sampling, which may compromise participation. The acceptance could be raised...
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Nationwide cervical cancer screening in Korea: data from the National Health Insurance Service Cancer Screening Program and National Cancer Screening Program, 2009–2014

Shim SH, Kim H, Sohn IS, Hwang HS, Kwon HS, Lee SJ, Lee JY, Kim SN, Lee K, Chang S

OBJECTIVE: The rates of participation in the Korean nationwide cervical cancer screening program and the rates of abnormal test results were determined. METHODS: The database of the National Health Insurance Service...
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Human Papillomavirus Genotype Distribution Among 18,815 Women in 13 Korean Cities and Relationship With Cervical Cytology Findings

Nah EH, Cho S, Kim S, Cho HI

BACKGROUND: The prevalence and genotype distribution of Human papillomavirus (HPV) infection vary depending on geographical region and the immunity provided by vaccines. This study aimed to clarify the recent prevalence...
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Atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion triage in Korean women: Revisiting the 2012 American Society of Colposcopy and Cervical Pathology screening guidelines

Hyun JY, Min KJ, Yang SY, Lee JK, Hong JH

OBJECTIVE: To determine whether triage for atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) from the updated American Society for Colposcopy and Cervical Pathology cervical...
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Current Cytology Practices in Korea: A Nationwide Survey by the Korean Society for Cytopathology

Oh EJ, Jung CK, Kim DH, Kim HK, Kim WS, Jin SY, Yoon HK, The Fellowship Council and Committee of Quality Improvement of the Korean Society for Cytopathology

BACKGROUND: Limited data are available on the current status of cytology practices in Korea. This nationwide study presents Korean cytology statistics from 2015. METHODS: A nationwide survey was conducted in 2016...
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Clinical Significance of an HPV DNA Chip Test with Emphasis on HPV-16 and/or HPV-18 Detection in Korean Gynecological Patients

Yeo MK, Lee A, Hur SY, Park JS

BACKGROUND: Human papillomavirus (HPV) is a major risk factor for cervical cancer. METHODS: We evaluated the clinical significance of the HPV DNA chip genotyping assay (MyHPV chip, Mygene Co.) compared with...
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DNA methylation in human papillomavirus-infected cervical cells is elevated in high-grade squamous intraepithelial lesions and cancer

Kim MK, Lee IH, Lee KH, Lee YK, So KA, Hong SR, Hwang CS, Kee MK, Rhee JE, Kang C, Hur SY, Park JS, Kim TJ

OBJECTIVE: DNA methylation has been shown to be a potential biomarker for early cancer detection. The aim of this study was to evaluate DNA methylation profiles according to liquid-based Pap...
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The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study

So KA, Kim MJ, Lee KH, Lee IH, Kim MK, Lee YK, Hwang CS, Jeong MS, Kee MK, Kang C, Cho CH, Kim SM, Hong SR, Kim KT, Lee WC, Park JS, Kim TJ

PURPOSE: The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined...
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