J Gynecol Oncol.  2020 Mar;31(2):e13. 10.3802/jgo.2020.31.e13.

Pathologic discrepancies between colposcopy-directed biopsy and loop electrosurgical excision procedure of the uterine cervix in women with cytologic high-grade squamous intraepithelial lesions

• Kim SI
• Kim SJ
• Suh DH
• Kim K
• No JH
• Kim YB

• KMID: 2470866
• DOI: http://doi.org/10.3802/jgo.2020.31.e13

Abstract

OBJECTIVE
To investigate pathologic discrepancies between colposcopy-directed biopsy (CDB) of the cervix and loop electrosurgical excision procedure (LEEP) in women with cytologic high-grade squamous intraepithelial lesions (HSILs).
METHODS
We retrospectively identified 297 patients who underwent both CDB and LEEP for HSILs in cervical cytology between 2015 and 2018, and compared their pathologic results. Considering the LEEP to be the gold standard, we evaluated the diagnostic performance of CDB for identifying cervical intraepithelial neoplasia (CIN) grades 2 and 3, adenocarcinoma in situ, and cancer (HSIL+). We also performed age subgroup analyses.
RESULTS
Among the study population, 90.9% (270/297) had pathologic HSIL+ using the LEEP. The diagnostic performance of CDB for identifying HSIL+ was as follows: sensitivity, 87.8%; specificity, 59.3%; balanced accuracy, 73.6%; positive predictive value, 95.6%; and negative predictive value, 32.7%. Thirty-three false negative cases of CDB included CIN2,3 (n=29) and cervical cancer (n=4). The pathologic HSIL+ rate in patients with HSIL− by CDB was 67.3% (33/49). CDB exhibited a significant difference in the diagnosis of HSIL+ compared to LEEP in all patients (p<0.001). In age subgroup analyses, age groups <35 years and 35-50 years showed good agreement with the entire data set (p=0.496 and p=0.406, respectively), while age group ≥50 years did not (p=0.036).
CONCLUSION
A significant pathologic discrepancy was observed between CDB and LEEP results in women with cytologic HSILs. The diagnostic inaccuracy of CDB increased in those ≥50 years of age.

Keyword

Papanicolaou Test; Colposcopy; Conization; High-Grade Squamous Intraepithelial Lesions; Uterine Cervical Neoplasms; Early Detection of Cancer

MeSH Terms

Adenocarcinoma in Situ
Biopsy*
Cervical Intraepithelial Neoplasia
Cervix Uteri*
Colposcopy
Conization
Dataset
Diagnosis
Early Detection of Cancer
Female
Humans
Papanicolaou Test
Retrospective Studies
Sensitivity and Specificity
Squamous Intraepithelial Lesions of the Cervix*
Uterine Cervical Neoplasms