- Cellular signaling in tissue regeneration
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Kim WJ
- KMID: 1114558
- Yonsei Med J.
- 2000 Dec;41(6):692-703.
- doi: 10.3349/ymj.2000.41.6.692
With recent progress in stem cell-based research, there has been tremendous interest in stem cell-based tissue regeneration. Stem cells can be differentiated into specialized cells/tissues by growth factors and cytokines.... -
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- The physiological meaning of rapid responses to steroid hormones in epithelia
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Harvey BJ
- KMID: 1026954
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S57-S58.
- doi: 10.3346/jkms.2000.15.S.S57
No abstract available. -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- Increased methylation of the cytosolic 20-kD protein is accompanied by liver regeneration in a hepatectomized rat
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Kwon SY, Kim S, Lee K, Kim TJ, Lee SH, Lee KM, Park GH
- KMID: 755670
- Exp Mol Med.
- 2004 Feb;36(1):85-92.
Arginine methylation has been implicated in the signal transduction pathway leading to cell growth. Here we show that a regenerating rat liver following partial hepatectomy exhibited elevated methyltransferase activity as... -
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- Biomedical significance of endothelial cell specific growth factor, angiopoietin
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Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC
- KMID: 1093591
- Exp Mol Med.
- 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth... -
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- Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes
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Choi K, Kim YB
- KMID: 1785667
- Korean J Intern Med.
- 2010 Jun;25(2):119-129.
- doi: 10.3904/kjim.2010.25.2.119
Insulin resistance is a major risk factor for developing type 2 diabetes caused by the inability of insulin-target tissues to respond properly to insulin, and contributes to the morbidity of... -
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- Human Papilloma Virus Type 16 E7 Genes Protect Astrocytes against Apoptotic and Necrotic Death Induced by Hydrogen Peroxide
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Lee WT, Lee JE, Lee SH, Jang HS, Giffard RG, Park KA
- KMID: 1728868
- Yonsei Med J.
- 2001 Oct;42(5):471-479.
- doi: 10.3349/ymj.2001.42.5.471
Hydrogen peroxide is considered to be a dose- and time-dependent mediator in apoptotic and necrotic death. In this study, we examined the signaling of the E6 and E7 proteins with... -
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- Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
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Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY
- KMID: 1072950
- Exp Mol Med.
- 2008 Dec;40(6):699-708.
- doi: 10.3858/emm.2008.40.6.699
Expression of protein kinase C-delta (PKC delta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKC delta gene transcription. In the present... -
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- Porcine circovirus type 2 increases interleukin-1beta and interleukin-10 production via the MyD88–NF-kappa B signaling pathway in porcine alveolar macrophages in vitro
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Han J, Zhang S, Zhang Y, Chen M, Lv Y
- KMID: 2412571
- J Vet Sci.
- 2017 Jun;18(2):183-191.
- doi: 10.4142/jvs.2017.18.2.183
Porcine alveolar macrophages (PAMs) represent the first line of defense in the porcine lung after infection with porcine circovirus type 2 (PCV2) via the respiratory tract. However, PCV2 infection impairs... -
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- Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling
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Sung YK, Hwang SY, Farooq M, Kim JC, Kim MK
- KMID: 1109313
- Exp Mol Med.
- 2003 Aug;35(4):257-262.
Glypican-3 (GPC3) encodes a cell-surface heparan-sulfate proteoglycan and its expression is frequently silenced in ovarian cancer, mesotheliomas, and breast cancer cell lines and ectopic expression of GPC3 inhibited the growth... -
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- Prologation of c-Jun N-Terminal Kinase is Associated with Cell Death Induced by Tumor Necrosis Factor Alpha in Human Chondrocytes
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Yoon HS, Kim HA
- KMID: 2157687
- J Korean Med Sci.
- 2004 Aug;19(4):567-573.
- doi: 10.3346/jkms.2004.19.4.567
The aim of this study was to elucidate the role of JNK signaling pathway involved in tumor necrosis factor-alpha (TNF-alpha)-induced death of chondrocytes. Primary chondrocyte cultures were obtained from human... -
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- CD98 activation increases surface expression and clusteringof beta 1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms
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Kim SM, Hahn JH
- KMID: 756327
- Exp Mol Med.
- 2008 Jun;40(3):261-270.
- doi: 10.3858/emm.2008.40.3.261
CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta 1 integrin- mediated cell adhesion. However, the molecular mechanisms underlying CD98-mediated activation of beta 1 integrin are presently unclear.... -
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- Morphine Postconditioning Attenuates ICAM-1 Expression on Endothelial Cells
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Min TJ, Kim JI, Kim JH, Noh KH, Kim TW, Kim WY, Lee YS, Park YC
- KMID: 1782121
- J Korean Med Sci.
- 2011 Feb;26(2):290-296.
- doi: 10.3346/jkms.2011.26.2.290
The purpose of this study is to determine 1) whether morphine postconditiong (MPostC) can attenuate the intercellular adhesion molecules-1 (ICAM-1) expression after reoxygenation injury and 2) the subtype(s) of the... -
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- Identification of high-affinity VEGFR3-binding peptides through a phage-displayed random peptide library
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Shi LF, Wu Y, Li CY
- KMID: 2345924
- J Gynecol Oncol.
- 2015 Oct;26(4):327-335.
- doi: 10.3802/jgo.2015.26.4.327
OBJECTIVE: Vascular endothelial growth factor (VEGF) interaction with its receptor, VEGFR-3/Flt-4, regulates lymphangiogenesis. VEGFR-3/Flt-4 expression in cancer cells has been correlated with clinical stage, lymph node metastasis, and lymphatic invasion.... -
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- Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions
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Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW
- KMID: 755659
- Exp Mol Med.
- 2004 Feb;36(1):1-12.
Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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