Yonsei Med J.  2000 Dec;41(6):692-703. 10.3349/ymj.2000.41.6.692.

Cellular signaling in tissue regeneration

• Kim WJ

• KMID: 1114558
• DOI: http://doi.org/10.3349/ymj.2000.41.6.692

Abstract

With recent progress in stem cell-based research, there has been tremendous interest in stem cell-based tissue regeneration. Stem cells can be differentiated into specialized cells/tissues by growth factors and cytokines. These small molecules are thought to play an important role in both wound healing and tissue regeneration. However, their biological activity and signal transduction during tissue regeneration are poorly understood. With recent advances in signal transduction by growth factors, the receptor kinases and G protein-coupled receptors, an understanding in the underlying mechanism of how these factors regulate tissue regeneration beginning to take place. In this review, the potential underlying mechanisms of growth factor signaling in normal tissue regeneration and chronic wound healing is discussed. Thus, it is an aim to provide a basis for designing more specific therapies for tissue regeneration in the near future.

Keyword

Growth factors; cytokines; chemokines; MCP-1; CCR2; receptors; keloids; hypertrophic scars; fibroproliferative disease; collagen; signal transduction; wound repair; injury; regeneration; stem cells; tissue engineering

MeSH Terms

Animal
Cell Physiology*
Chemokines/physiology
Chronic Disease
Growth Substances/physiology
Human
Keloid/therapy
Keloid/physiopathology
Regeneration/physiology*
Signal Transduction/physiology*
Wound Healing/physiology