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BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors

Kim M, Kim Sj, Ha SY, Xu Z, Han Y, Jee HG, Cho SW, Park YJ, Lee KE

Background: Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown. We elucidated the effect of...
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Anti-adipogenic Effect and Mechanism in 3T3-L1 Preadipocyte Differentiation by Salvianolic Acid B

Kwon HS, Jang BC

Salvianolic acid B (Sal B) is one of the most active hydrophilic compounds extracted from Salvia miltiorrhiza root. Previous in vitro and in vivo studies demonstrate the ability of Sal...
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Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study

Ku BM, Park S, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Choi YL, Ahn MJ

Purpose: Mesenchymal-epithelial transition tyrosine kinase receptor (MET) amplification is one of the common acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). To evaluate the usefulness...
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Malignant Apocrine Lesions of the Breast: Multimodality Imaging Findings and Biologic Features

Lee Hj, Kang SW, Lee JE, Jeong WG, Lee JS, Park MH, Lim HS

The apocrine morphology of the breast is observed in a broad pathological spectrum, ranging from benign cysts to invasive carcinomas. However, the number of clinical research investigating malignant apocrine lesions...
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Pregnancy After Breast Cancer – Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review

Nolan K, Boland MR, Hill AD

Purpose: Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research...
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Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat

Youn Dh, Jun J, Kim TW, Park K

Background: Repeated administration of opioid analgesics for pain treatment can produce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus, this study investigated whether spinally (centrally) administered orexin A attenuates opioid-induced...
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Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala

Zhu Y, Sun M, Liu P, Shao W, Xiong M, Xu B

Background: The decreased expression of mu-opioid receptors (MOR) in the amygdala may be a key molecular in chronic post-surgical pain (CPSP). It is known that miR-339-5p expression in the amygdala...
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The role of botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

Bu H, Jiao P, Fan X, Gao Y, Zhang L, Guo H

Background: The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) as well as GABA...
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68Ga‑DOTATATE Avid Metastatic Vertebral Renal Cell Carcinoma in the Setting of von Hippel‑Lindau Syndrome

Patel M, Jha A, Antic T, Nielsen S, Churpek J, Ling A, Pacak K

Although rare, a metastatic renal cell carcinoma could present with 68Ga-DOTATATE avidity. A 66-year-old man with von Hippel-Lindau syndrome (VHL) presented with 68Ga-DOTATATE uptake in the pancreatic head, splenic hilar...
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The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer

Song IH, Kim YA, Heo SH, Bang WS, Park HS, Choi Yh, Lee H, Seo JH, Cho Y, Jung SW, Kim HJ, Ahn SH, Lee HJ, Gong G

Purpose The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level of tumor-infiltrating...
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Evaluation of Anti-cancer and Anti-proliferative Activity of Medicinal Plant Extracts (Saffron, Green Tea, Clove, Fenugreek) on Toll Like Receptors Pathway

Ajmal S, Shafqat M, Ajmal L, Younas H, Tasadduq R, Mahmood N

Despite considerable efforts, cancer remains an aggressive killer worldwide. Chemotherapeutic drugs that are currently in use lead to destructive side effects and have not succeeded in fulfilling expectations. For centuries,...
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Current and future perspectives on CAR-T cell therapy for renal cell carcinoma: A comprehensive review

Kim TJ, Lee YH, Koo KC

In the clinical setting of renal cell carcinoma (RCC), immune reactions such as tumor-specific T cell responses can be spontaneous events or can be elicited by checkpoint inhibitors, cytokines, and...
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Time to Chemotherapy for Patients With Estrogen Receptor-Positive Breast Cancer and Cyclin-Dependent Kinase 4 and 6 Inhibitor Use

Endo Y, Yoshimura A, Sawaki M, Hattori M, Kotani H, Kataoka A, Horisawa N, Ozaki Y, Nozawa K, Takatsuka D, Isogai A, Iwata H

Purpose: Safely postponing the use of chemotherapy is important for quality of life maintenance in patients with hormone receptor-positive advanced breast cancer. In previous studies, a combination of cyclin-dependent kinase...
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A study on the effect of JNJ-10397049 on proliferation and differentiation of neural precursor cells

Karami N, Azari H, Rahimi M, Aligholi H, Kalantari T

The orexin 2 receptor plays a central role in maintaining sleep and wakefulness. Recently, it has been shown that sleep and wakefulness orchestrate the proliferation and differentiation of oligodendrocytes. Here,...
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GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells

Kim JW, Roh E, Choi KM, Yoo HJ, Hwang HJ, Baik SH

Endothelial dysfunction is strongly linked with inflammatory responses, which can impact cardiovascular disease. Recently, G protein-coupled receptor 40 (GPR40) has been investigated as a modulator of metabolic stress; however, the...
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Usefulness of Real-Time Quantitative Microvascular Ultrasonography for Differentiation of Graves’ Disease from Destructive Thyroiditis in Thyrotoxic Patients

Baek HS, Park JY, Jeong CH, Ha J, Kang MI, Lim DJ

Background: Microvascular ultrasonography (MVUS) is a third-generation Doppler technique that was developed to increase sensitivity compared to conventional Doppler. The purpose of this study was to compare MVUS with conventional...
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The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Huang YH, Hsu KH, Chin CS, Tseng JS, Yang TY, Chen KC, Su KY, Yu SL, Chen JJ, Chang GC

Purpose The aim of this study was to investigate the efficacy of various epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) plus bevacizumab in advanced EGFR-mutant lung adenocarcinoma patients. Materials and Methods From...
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Bioaerosol Exposure and in vitro Activation of Toll-like Receptors in a Norwegian Waste Sorting Plant

Eriksen E, Graff P, Pedersen I, Straumfors A, Afanou AK

Background The global shift toward greener societies demands new technologies and work operations in the waste-management sector. However, progressive industrial methods do not necessarily consider workers’ health. This study characterized workers'...
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Individualized Treatment for Patients With Familial Hypercholesterolemia

Tada H, Takamura M, Kawashiri Ma

Familial hypercholesterolemia (FH) is one of the most common and, therefore, important inherited disorders in preventive cardiology. This disease is mainly caused by a single pathogenic mutation in the low-density...
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Anti-nociceptive and anti-inflammatory activities of the essential oil isolated from Cupressus arizonica Greene fruits

Fakhri S, Jafarian S, Majnooni MB, Farzaei MH, Mohammadi-Noori E, Khan H

Background: Cupressus arizonica Greene is a coniferous tree with great importance in fragrance and pharmaceutical industries. Essential oils from C. arizonica (EC) have shown potential antioxidant, and anti-microbial activities. This...
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