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New horizon of SERM and tissue specific effect

Park HM

  • KMID: 1551286
  • Korean J Med.
  • 1999 Oct;57(4):467-471.
No abstract available.
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Selective Estrogen Receptor Modulators

An KC

Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen...
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Selective Estrogen Receptor Modulators: A Review of Action Mechanism and Clinical Data

Kim SS

Selective estrogen receptor modulators (SERMs) are a diverse group of synthetic non-steroidal compounds that have various levels of estrogen receptor (ER) agonist or antagonist activity depending on the target tissue....
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Pattern Alopecia during Hormonal Anticancer Therapy in Patients with Breast Cancer

Park J, Kim JI, Yun SK, Kim HU, Ihm CW

We report five cases of pattern alopecia in female patients who are undergoing hormonal anticancer therapy for the prevention of recurrence of breast cancer after surgery. Three patients demonstrated male...
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Growth Inhibition of Human Uterine Leiomyoma Cells by Selective Estrogen Receptor Modulator

Lee MY, Cho CH, Kwon SH, Song DK, Chung SW, Kang HO, Yoon SD, Cha SD

  • KMID: 2272357
  • Korean J Obstet Gynecol.
  • 2004 Jun;47(6):1071-1079.
OBJECTIVE: Our purpose was to evaluate potential efficacy of selective estrogen receptor modulators (raloxifene and tamoxifen) to human uterine leiomyoma cells. METHODS: The samples were collected from ten hysterectomized specimen. we...
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Current and Upcoming Treatments for Osteoporosis

Chung YS

Osteoporosis is a common senile disease that results in fragility fractures. With an ageing population, the medical and socioeconomic effect of osteoporosis, particularly postmenopausal osteoporosis, will increase further. Currently, good...
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The effects of Raloxifene therapy on endometrium in postmenopausal women

Kim GJ, Park HM

  • KMID: 2272575
  • Korean J Obstet Gynecol.
  • 2005 Apr;48(4):962-968.
OBJECTIVE: To determine the effects of a selective estrogen receptor modulator (SERM), raloxifene, on endometrium in postmenopausal women. METHODS: Double-blind randomized controlled study was designed for 138 healthy postmenopausal women to...
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Endocrine Therapy for Breast Cancer

Woo J, Lim W

Breast cancer is the second most common cancer in Korean women and its mortality rate has increased steadily. Although breast cancer is heterogeneous tumor, hormone receptor-positive tumors comprise about 75...
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An Overview of the Clinical Efficacy and Safety of Tissue Selective Estrogen Complex: From the Selective Estrogens, Menopause, and Response to Therapy (SMART) Trials

Chun SW

Hormone therapy (HT) is the most effective treatment for menopausal symptoms, and reduces both spinal and non-spinal postmenopausal osteoporotic fractures. However, a Women's Health Initiative (WHI) trial revealed that progestin-containing...
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Factors Influencing the Background Parenchymal Enhancement in Follow-Up Breast MRI after Adjuvant Endocrine Therapy

Youk JH, Son EJ, Kim JA

PURPOSE: To investigate factors influencing the evaluation of background parenchymal enhancement (BPE) at follow-up breast magnetic resonance imaging (MRI) after adjuvant endocrine therapy. MATERIALS AND METHODS: One hundred twelve women with...
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Current Treatment of Postmenopausal Osteoporosis

Yoon SH, Kim JG

  • KMID: 2272562
  • Korean J Obstet Gynecol.
  • 2005 Apr;48(4):844-856.
Osteoporosis is a silent disease which causes a serious morbidity such as fracture. Once osteoporosis risk has been established in postmenopausal women, dietary and lifestyle changes, such as exercise, discontinuing...
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Influence of Supplementary Vitamin D on Bone Mineral Density When Used in Combination with Selective Estrogen Receptor Modulators

Liu HJ, Kim SA, Shim DJ, Jung JM, Lee EJ

OBJECTIVES: Vitamin D is regarded as one of the major nutrients that significantly influence bone metabolism. This study aims to look at the effect of supplementary vitamin D on bone...
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Conservative Treatment of Osteoporotic Spinal Fractures

Lee JH, Jin Y, Lee JH

STUDY DESIGN: Literature review. OBJECTIVES: To present updated information on the conservative treatment of osteoporotic spinal fractures (OSFs). SUMMARY OF LITERATURE REVIEW: The treatments of osteoporotic spinal fractures are bed rest, pain...
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Uterine Malignant Mixed Müllerian Tumors Following Treatment with Selective Estrogen Receptor Modulators in Patients with Breast Cancer: A Report of 13 Cases and Their Clinicopathologic Characteristics

Jeong BK, Sung CO, Kim KR

BACKGROUND: Breast cancer treatment with selective estrogen receptor modulators (SERMs) increases the incidence of uterine malignant mixed Müllerian tumors (uMMMTs). We examine clinicopathologic characteristics and prognosis of SERM-associated uMMMTs (S-uMMMTs)...
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Diagnosis and Treatment of Osteoporosis

Limpaphayom KK, Kim HY

  • KMID: 1993589
  • Kosin Med J.
  • 2011 Dec;26(2):121-126.
Osteoporosis is common among older adults and results in costly osteoporotic fractures. With the aging of the population, low bone mass states will be an increasing clinical issue for both...
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Comparison of Anti-osteoporotic Medications and Alternatives

Kang BM

  • KMID: 2272985
  • Korean J Obstet Gynecol.
  • 2006 Dec;49(12):2459-2472.
Osteoporosis becomes a serious health threat for aging postmenopausal women by predisposing them to an increased risk of fracture. Conventional pharmacological options are available for osteoporosis therapy, including bisphosphonates, the...
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Recent Advances in the Drug Therapy of Osteoporosis

Lee HW

  • KMID: 2320272
  • Yeungnam Univ J Med.
  • 1999 Dec;16(2):155-168.
Osteoporosis is one of the most important public health problems facing the aging population. Drug therapy for osteoporosis can be divided operationally into two main categories: drugs that inhibit bone...
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Pharmacologic treatment of osteoporosis

Min YK

The objectives of this article are to review current pharmacologic approaches for the treatment of osteoporosis in Korea. Calcium and vitamin D supplementation are necessary for osteoporotic patients with inadequate...
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Pharmacological treatment of osteoporosis

Chun S

Osteoporosis is a skeletal disorder characterized by compromised bone strength resulting in a predisposition to fracture. Osteoporosis-related fractures can lead to pain, disability, and increased healthcare costs. This study aimed...
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Prescription Patterns of Anti-osteoporosis Medications by Gynecologists

Lee ES, Jang SH, Park HM

  • KMID: 2321360
  • J Korean Soc Menopause.
  • 2011 Apr;17(1):34-40.
OBJECTIVES: To describe prescription patterns by gynecologists for osteoporosis therapy and to compare with the prescription patterns by physicians of other medical specialties based on the data from the Health...
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