Korean J Obstet Gynecol.  2005 Apr;48(4):962-968.

The effects of Raloxifene therapy on endometrium in postmenopausal women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea. hmpark@hananet.net

Abstract


OBJECTIVE
To determine the effects of a selective estrogen receptor modulator (SERM), raloxifene, on endometrium in postmenopausal women.
METHODS
Double-blind randomized controlled study was designed for 138 healthy postmenopausal women to determine the effects of raloxifene on postmeonopausal endometrium. The women were randomly assigned to receive either placebo, or raloxifene HCl 60 mg/day for 6 months. Transvaginal ultrasound was done at baseline and at 6 months later.
RESULTS
Mean endometrial thickness of normal postmenopausal women was 3.4 ( +/- 1.6) mm. Mean endometrial thickness was decreased by 0.2 mm in both groups, but with no statistical significance.
CONCLUSION
Raloxifene 60 mg/day did not stimulate the endometrium after 6 months of use in postmenopausal women.

Keyword

Raloxifene; Endometrium; Postmenopause
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