Asian Spine J.  2016 Aug;10(4):787-791. 10.4184/asj.2016.10.4.787.

Selective Estrogen Receptor Modulators

• An KC

• KMID: 2349306
• DOI: http://doi.org/10.4184/asj.2016.10.4.787

Abstract

Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target tissue. After tamoxifen, raloxifene, lasofoxifene and bazedoxifene SERMs have been developed and used for treatment. The clinically decisive difference among these drugs (i.e., the key difference) is their endometrial safety. Compared to bisphosphonate drug formulations for osteoporosis, SERMs are to be used primarily in postmenopausal women of younger age and are particularly recommended if there is a family history of invasive breast cancer, as their use greatly reduces the incidence of this type of cancer in women. Among the above mentioned SERMs, raloxifene has been widely used in prevention and treatment of postmenopausal osteoporosis and vertebral compression fractures, and clinical studies are now underway to test the comparative advantages of raloxifene with those of bazedoxifene, a more recently developed SERM. Research on a number of adverse side effects of SERM agents is being performed to determine the long-term safety of this class of compouds for treatment of osteoporosis.

Keyword

Osteoporosis; Selective estrogen receptor modulators

MeSH Terms

Breast Neoplasms
Chemistry, Pharmaceutical
Estrogens
Female
Fractures, Compression
Humans
Incidence
Osteoporosis
Osteoporosis, Postmenopausal
Raloxifene Hydrochloride
Selective Estrogen Receptor Modulators*
Tamoxifen
Estrogens
Raloxifene Hydrochloride
Selective Estrogen Receptor Modulators
Tamoxifen