- The Effect and Mechanism of the Specific Phosphodiesterase (PDE) III-Inhibitor Milrinone on Human and Rabbit Corpus Cavernosum
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Jeon SS, Paick JS, Kim SW
- KMID: 1914081
- Korean J Urol.
- 1996 Oct;37(10):1067-1074.
Milrinone is a positive inotropic/vasodilator agent in both preclinical and clinical studies. Milrinone has been shown previously to inhibit specific type III PDE isolated from different sources. To investigate the... -
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- Effects of Sphingosine-1-Phosphate on Neural Differentiation and Neurite Outgrowth in Neuroblastoma Cells
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Lee JH, Jang S, Jeong HS, Park JS
- KMID: 2172241
- Chonnam Med J.
- 2011 Apr;47(1):27-30.
- doi: 10.4068/cmj.2011.47.1.27
Sphingosine-1-phosphate (S1P) is emerging as a new class of second messenger involved in cellular proliferation, differentiation, and apoptosis and is implicated in diverse physiological functions. Despite many studies on the... -
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- Estrogen Effects and Mechanism of Action in the Central Nervous System
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Joe SH, Kim JW
- KMID: 2287305
- Korean J Psychopharmacol.
- 2003 Dec;14(4):316-329.
Estrogens have diverse effects on the CNS throughout the lifespan and do so via multiple mechanisms involving both genomic and non-genomic receptors. Estrogens affect not only the hypothalamus but also... -
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- p38 MAPK and NF-kappaB are required for LPS-induced RANTES production in immortalized murine microglia (BV-2)
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Jang SB, Lee KH
- KMID: 1580930
- Korean J Physiol Pharmacol.
- 2000 Oct;4(5):339-346.
Using murine immortalized microglial cells (BV-2), we examined the regulation of RANTES production stimulated by lipopolysaccharide (LPS), focusing on the role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB. The result showed... -
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- Rapid, Non-genomic Reduction of Intracelluar[Ca2+] and Mucin Secretion by Steroid Hormones in Human Nasal Epithelial Cells
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Kim TH, Kim DR, Cha SK, Moon JH, Kim SI, Park DJ
- KMID: 2276438
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Jul;48(7):870-876.
BACKGROUND AND OBJECTIVES: Airway mucus hypersecretion is one of the major clinical manifestation of patients suffering from various upper or lower respiratory tract diseases. But unfortunately, no drugs are yet... -
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- Purification of Inositol Triphosphate Kinase from Bovine Brain
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Kim HH, Lee JT
- KMID: 2320357
- Yeungnam Univ J Med.
- 1996 Jun;13(1):46-58.
- doi: 10.12701/yujm.1996.13.1.46
Inositol 1,4,5-triphosphate(InsP,) is a second messenger for obilizing intracellular Cal'. It can be dephosphorylated by soluble and particulate forms on InsP, 5-phosphatase, or phosphorylated to produce inositol 1,3,4,5-tetrakisphosphate(InsP,) by InsP,... -
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- G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
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Kim MJ, Kim TH, Lee HH
- KMID: 2200980
- J Menopausal Med.
- 2015 Aug;21(2):79-81.
- doi: 10.6118/jmm.2015.21.2.79
Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active... -
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- Homogeneity of Phospholipase C of Bovine Uterus and Seminal Vesicle Compared with Brain Isozymes
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Kim JH, Lee KY, Rhee SG
- KMID: 2376234
- Yeungnam Univ J Med.
- 1988 Dec;5(2):37-45.
- doi: 10.12701/yujm.1988.5.2.37
Phosphoinositide-specific Phospholipase C (PI-PLC) is a second messenger of signal transducer on cell membrane. In the previous study, PLC of bovine brain has been purified three isozymes. In this paper,... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Regulation of Ca2+ Signaling in Pulmonary Hypertension
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Firth AL, Won JY, Park WS
- KMID: 1432756
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):1-8.
- doi: 10.4196/kjpp.2013.17.1.1
Understanding the cellular and molecular mechanisms involved in the development and progression of pulmonary hypertension (PH) remains imperative if we are to successfully improve the quality of life and life... -
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- The mechanism of phospholipase C-gamma1 regulation
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Kim MJ, Kim EK, Ryu SH, Suh PG
- KMID: 755072
- Exp Mol Med.
- 2000 Sep;32(3):101-109.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while... -
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- The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease
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Yarosz EL, Chang CH
- KMID: 2404896
- Immune Netw.
- 2018 Feb;18(1):e14.
- doi: 10.4110/in.2018.18.e14
T lymphocytes rely on several metabolic processes to produce the high amounts of energy and metabolites needed to drive clonal expansion and the development of effector functions. However, many of... -
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- The Effects of Chronic Carbamazepine Administration on Protein Kinase A and Protein Kinase C Activities in Rat Brain
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Rheem DW, Kim L, Suh KY
- KMID: 2334572
- J Korean Soc Biol Psychiatry.
- 1998 Nov;5(2):227-234.
OBJECTIVE: Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning... -
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- A Case of Pseudohypoparathyroidism in a Premature Infant
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Yang JI, Seo JW, Kim JY
- KMID: 2206978
- J Korean Pediatr Soc.
- 2003 Oct;46(10):1032-1035.
In pseudohypoparathyroidism as reported by Albright in 1942, the parathyroid gland can normally synthesize and secrete parathyroid hormone(PTH). Pseudohypoparathyroidism has a similar biochemical finding with hypoparathyroidisms like hypocalcemia and hyperphosphatemia... -
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- New PDEs Inhibitors for Erectile Dysfunction
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Choi HK
- KMID: 2183138
- J Korean Med Assoc.
- 2003 Nov;46(11):1050-1056.
- doi: 10.5124/jkma.2003.46.11.1050
Phosphodiesterases (PDEs) are functionally diverse enzymes with wide organ and tissue distributions. Of these enzymes, PDE5 has received particular attention largely because of the introduction and widespread use of the... -
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- Protective Effect of Magnolol Against Ceramide-induced Apoptosis in SK-N-SH cells
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Lee DY, Kim SS, Kim KY, Lee WB
- KMID: 1917151
- Korean J Phys Anthropol.
- 2003 Jun;16(2):119-127.
Magnolol, isolated from the stem bark of Magnolia officnalis, is typical Oriental herbs. It has been known to have many biological activities such as anti-platelet aggregation, hydroxyl radical scavenging, Ca2+... -
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- The mRNA Expression of Phosphoinositide-specific Phospholipase C-beta Isozymes in Postnatal Rat Brains
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Rhyu IJ, Kim H, Kang YH, Park K, Hwang SJ, Suh PG, Suh YS
- KMID: 2092655
- Korean J Anat.
- 1998 Aug;31(4):535-544.
Phosphoinositide-specific phospholipase C(PLC) is known as a key enzyme which produces two major second messengers: diacylglycerol and inositol 1,4,5 trisphosphate. Although it has been suggested that PLC beta isozymes have... -
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- Calcium Signaling in Salivary Secretion
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Kim JM, Lee SW, Park K
- KMID: 2405561
- J Korean Dent Sci.
- 2017 Dec;10(2):45-52.
- doi: 10.5856/JKDS.2017.10.2.45
Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca²⺠plays a key role during the secretion of salivary glands. In this review, we introduce the diverse... -
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- A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
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Karunakaran U, Park KG
- KMID: 2280711
- Diabetes Metab J.
- 2013 Apr;37(2):106-112.
- doi: 10.4093/dmj.2013.37.2.106
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially beta-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as... -
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- Relaxation Effect of Synthetic Ceramide Analogues in Cat Esophageal Smooth Muscle Cells
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Lee DW, Park SY, Ryu JS, Kim SH, Im CU, Choi SH, Lee SE, Ko SK, Sohn UD
- KMID: 1838350
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):137-142.
- doi: 10.4196/kjpp.2008.12.4.137
Ceramide has emerged as a novel second messenger for intracellular signalling. It is produced from sphingomyelin and is involved in the control of cell differntiation, proliferation, and apoptosis. C2- ceramide,... -
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