J Menopausal Med.  2015 Aug;21(2):79-81. 10.6118/jmm.2015.21.2.79.

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health

  • 1Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. heeobgy@schmc.ac.kr
  • 2Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University, Asan, Korea.


Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.


Estradiol; Estrogens; Genomics; GTP-binding proteins

MeSH Terms

GTP-Binding Proteins*
Receptors, Cytoplasmic and Nuclear
Second Messenger Systems
Transcription Factors
Women's Health*
GTP-Binding Proteins
Receptors, Cytoplasmic and Nuclear
Transcription Factors


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