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The prognostic significance and treatment modality for elevated pre- and postoperative serum CEA in colorectal cancer patients

Yang KM, Park IJ, Kim CW, Roh SA, Cho DH, Kim JC

PURPOSE: The purpose of this study was to evaluate the prognostic significance of serum CEA (s-CEA) changes in colorectal cancer (CRC) patients with sustained elevated postoperative s-CEA levels. METHODS: Between January...
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Characterization of biological responses of colorectal cancer cells to anticancer regimens

Roh SA, Choi EY, Cho DH, Yoon YS, Kim TW, Kim YS, Kim JC

PURPOSE: Identification of subgroups of patients who differ in their response to treatment could help to establish which of the best available chemotherapeutic options are best, based on biological activity....
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Invasiveness of and Drug Sensitivity to Various Anti-cancer Regimens in Five Colorectal Cancer Cell Lines

Lee YM, Yoon YS, Roh SA, Cho DH, Kim JC

PURPOSE: Colorectal cancer (CRC) is one of the leading causes of cancer death in South Korea. Angiogenesis has been associated with invasion and metastasis of tumors and with the secretion...
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Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change

Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC

Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated....
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Comparison between Therapeutic Efficacies of Histone Deacetylase Inhibitors and Established Drug Regimens Against Breast Cancer Cells using the Histoculture Drug Response Assay

Seo JY, Lee YM, Cho DH, Roh SA, Ro SG, Hyun YL, Kim SY, Kim YS, Kim TW, Ahn SH, Kim JC

PURPOSE: Histone deacetylase inhibitors (HDACIs) induce accumulation of acetylated histones in nucleosomes, which lead to reactivate gene expression and inhibit the growth and survival of tumor cells. This study evaluated...
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CpG Island Methylation in Familial Colorectal Cancer Patients Not Fulfilling the Amsterdam Criteria

Kim HC, Lee HJ, Roh SA, Kim JS, Yu CS, Kim JC

To determine the role of methylation in colorectal cancer patients with a family history, we enrolled 25 colorectal cancer patients with a family history of colorectal cancer but without a...
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Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas

Roh SA, Kim HC, Kim JS, Kim JC

The high-frequency microsatellite instability (MSI-H) phenotype, frequently identified in hereditary nonpolyposis colorectal cancer (HNPCC), also accounts for approximately 15% of sporadic colorectal cancers. Microsatellite instability (MSI) occurs from the mutational...
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Microsatellite Instability and Promoter Methylation of hMLH1 in Sporadic Gastric Carcinoma

Kim HC, Roh SA, Yook JH, Oh ST, Kim BS, Yu CS, Kim JC

  • KMID: 2372717
  • J Korean Gastric Cancer Assoc.
  • 2003 Mar;3(1):50-55.
BACKGROUND: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of...
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Loss of E-cadherin Function is Suggested to be Associated with Peritoneal Seeding in Colorectal Cancer

Kim HC, Roh SA, Kim JS, Yu CS, Kim JC

  • KMID: 1626388
  • J Korean Soc Coloproctol.
  • 2003 Feb;19(1):20-25.
PURPOSE: We investigated whether the loss of E-cadherin function was related to the peritoneal seeding in colorectal carcinomas. METHODS: Eleven patients who had undergone a palliative resection for a colorectal carcinoma,...
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Somatic Mutations of APC Presenting Polymorphisms in the Hamartomatous Polyps of the Colon

Kim JC, Roh SA, Kim HC, Yu CS, Beck NE, Bodmer WF

  • KMID: 2175141
  • J Korean Cancer Assoc.
  • 1999 Dec;31(6):1288-1296.
No abstract available.
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