- The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Park YY, Nam HJ, Do M, Lee JH
- KMID: 2361537
- Exp Mol Med.
- 2016 Aug;48(8):e250.
- doi: 10.1038/emm.2016.61
RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription,... -
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- Phosphorylated S6 Kinase-1 as Predictive Marker of Lapatinib Efficacy in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients
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Ko EB, Seong MK, Choi HS, Park CS, Choi JH, Lee JK, Seol H, Kim HA, Noh WC
- KMID: 2401816
- J Breast Dis.
- 2017 Dec;5(2):57-63.
- doi: 10.14449/jbd.2017.5.2.57
PURPOSE: The 40S ribosomal protein S6 kinase-1 (S6K1) is a crucial downstream effector of the PI3K/AKT/mTOR pathway. S6K1 overexpression is found in 10% to 30% of breast cancers and is... -
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- The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line
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Kim HS, Kim SJ, Bae J, Wang Y, Park SY, Min YS, Je HD, Sohn UD
- KMID: 2364263
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):595-603.
- doi: 10.4196/kjpp.2016.20.6.595
Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is... -
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- The Role of Akt-1/PKBalpha on Insulin Action in 3T3-L1 Adipocyte
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Lee JM, Son HS, Kwon HS, Kwack SK, Ko SH, Chang SA, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Sharma P
- KMID: 2177818
- J Korean Diabetes Assoc.
- 2002 Aug;26(4):274-285.
BACKGROUNDS: Akt/PKB as a serine/threonine kinase is stimulated by insulin and other growth factors. And insulin stimulates glucose uptake by promoting the translocation of glucose transporter 4 (GLUT4) to the... -
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- Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485
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Rakhmanova V, Jin M, Shin J
- KMID: 2414558
- Immune Netw.
- 2018 Jun;18(3):e18.
- doi: 10.4110/in.2018.18.e18
Mast cells integrate innate and adaptive immunity and are implicated in pathophysiological conditions, including allergy, asthma, and anaphylaxis. Cross-linking of the high-affinity IgE receptor (FcεRI) initiates diverse signal transduction pathways... -
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- Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
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Park JA, Lee CH
- KMID: 2429050
- Biomol Ther.
- 2018 Mar;26(2):115-120.
- doi: 10.4062/biomolther.2016.248
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- Bilirubin Activates Transcription of HIF-1alpha in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content
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Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ
- KMID: 2069806
- J Korean Med Sci.
- 2014 Sep;29(Suppl 2):S146-S154.
- doi: 10.3346/jkms.2014.29.S2.S146
The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which... -
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- Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma
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Park S, Lim J, Kim JR, Cho S
- KMID: 2398500
- J Vet Sci.
- 2017 Dec;18(4):419-429.
- doi: 10.4142/jvs.2017.18.4.419
Liver cancer occurs very frequently worldwide and hepatocellular carcinoma (HCC) accounts for more than 80% of total primary liver cancer cases. In this study, the anticarcinogenic effects of resveratrol against... -
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- Predicting the Benefit of Adjuvant Aromatase Inhibitor Therapy in Postmenopausal Breast Cancer Patients with Phosphorylated S6K1 Expression Status
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Choi J, Park CS, Seong MK, Seol H, Kim JS, Park IC, Noh WC, Kim HA
- KMID: 2470878
- J Breast Cancer.
- 2020 Feb;23(1):10-19.
- doi: 10.4048/jbc.2020.23.e5
PURPOSE: Phosphorylated ribosomal S6 kinase 1 (pS6K1) is a major downstream regulator of the mammalian target of rapamycin (mTOR) pathway. Recent studies have addressed the role of S6K1 in adipogenesis.... -
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- The Clinicopathological Factors That Determine a Local Recurrence of Rectal Cancers That Have Been Treated with Surgery and Chemoradiotherapy
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Choi CW, Kim MS, Yoo SY, Cho CK, Yang KM, Yoo HJ, Seo YS, Kim MS, Lee SS, Hwang DY, Moon SM
- KMID: 2003459
- J Korean Soc Ther Radiol Oncol.
- 2006 Dec;24(4):255-262.
PURPOSE: To evaluate the pathological prognostic factors related to local recurrence after radical surgery and adjuvant radiation therapy in advanced rectal cancer. MATERIALS AND METHODS: Fifty-four patients with advanced rectal cancer... -
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- Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
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Tang JC, An R, Jiang YQ, Yang J
- KMID: 2388323
- Cancer Res Treat.
- 2017 Jul;49(3):778-789.
- doi: 10.4143/crt.2015.485
PURPOSE: The purpose of this study was to observe the effects of metformin on human esophageal cancer cell and to investigate its possible mechanisms. MATERIALS AND METHODS: Cell viability was detected... -
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- Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis
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Kim JW, Jeong JH
- KMID: 2444199
- Korean J Neurotrauma.
- 2019 Apr;15(1):2-10.
- doi: 10.13004/kjnt.2019.15.e2
OBJECTIVE: Astrocyte dysfunctions are related to several central nervous system (CNS) pathologies. Transcriptomic profiling of human mRNAs to investigate astrocyte functions may provide the basic molecular-biological data pertaining to the... -
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- P70S6K and Elf4E Dual Inhibition Is Essential to Control Bladder Tumor Growth and Progression in Orthotopic Mouse Non-muscle Invasive Bladder Tumor Model
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Chi BH, Kim SJ, Seo HK, Seo HH, Lee SJ, Kwon JK, Lee TJ, Chang IH
- KMID: 2133310
- J Korean Med Sci.
- 2015 Mar;30(3):308-316.
- doi: 10.3346/jkms.2015.30.3.308
We investigated how the dual inhibition of the molecular mechanism of the mammalian target of the rapamycin (mTOR) downstreams, P70S6 kinase (P70S6K) and eukaryotic initiation factor 4E (eIF4E), can lead... -
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- Chronic activation of CREB and p90RSK in human epileptic hippocampus
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Park SA, Kim TS, Choi KS, Park HJ, Heo K, Lee BI
- KMID: 1093608
- Exp Mol Med.
- 2003 Oct;35(5):365-370.
Mesial temporal lobe epilepsy (MTLE) is associated with severe neuronal death and reactive gliosis in hippocampus. However, the molecular mechanisms underlying these pathological changes remain unanswered. ERK has been reported... -
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- 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice
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Zhang EY, Gao B, Shi HL, Huang LF, Yang L, Wu XJ, Wang ZT
- KMID: 2395749
- Exp Mol Med.
- 2017 Oct;49(10):e387.
- doi: 10.1038/emm.2017.151
Impaired angiogenesis is one of the crucial factors that impede the wound healing process in diabetic foot ulcers (DFUs). In this study, we found that 20(S)-protopanaxadiol (PPD), an aglycone of... -
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- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells
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Lee Y, Broxmeyer , Mantel C, Kwon HJ, Kim JW, Kim JS, Kwon D, Choe IS
- KMID: 1094704
- Exp Mol Med.
- 2003 Jun;35(3):222-226.
Stem cell factor (SCF) is an early-acting cytokine inducing proliferative synergy with other cytokines in hematopoietic cells. We earlier showed that p21 was synergistically induced in SCF synergy and the... -
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- The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
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Park S, Lim S, Chang W, Song H, Lee S, Song BW, Kim HJ, Cha MJ, Choi E, Jang Y, Chung N, Cho SY, Hwang KC
- KMID: 1793194
- Yonsei Med J.
- 2008 Aug;49(4):592-600.
- doi: 10.3349/ymj.2008.49.4.592
PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms... -
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