- Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon
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Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR
- KMID: 2433475
- J Neurogastroenterol Motil.
- 2015 Jul;21(3):361-369.
- doi: 10.5056/jnm14157
BACKGROUND/AIMS: Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine... -
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- Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle
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Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD
- KMID: 2071728
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):267-272.
- doi: 10.4196/kjpp.2011.15.5.267
A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes.... -
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- The Effect of 5-Hydroxytryptamine Type 3 Receptor Antagonist on the Motor Activity of the Sphincter of Oddi
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Ryu HS, Kim CD, Jeen YT, Hyum JH
- KMID: 2240631
- Korean J Gastroenterol.
- 1998 Apr;31(4):532-540.
BACKGROUND AND AIMS: The sphincter of Oddi motor activity is modulated by multifactorial and various neural and hormonal factors. However, it has not been studied whether 5-HT3 receptor antagonist modulate... -
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- Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain
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Jung KT, Yoon MH, Lee HY, Yu BY, Kim DK, Lim KJ
- KMID: 1978655
- Korean J Pain.
- 2013 Apr;26(2):125-129.
- doi: 10.3344/kjp.2013.26.2.125
BACKGROUND: 5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or... -
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- Psychosis in Parkinson
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Koh SB, Park KW, Lee DH
- KMID: 1944956
- J Korean Soc Biol Psychiatry.
- 1997 Jun;4(1):132-135.
Current treatment strategies for levodopa-induced psychosis in advanced Parkinson's disease have had limited success. Reduction or discontinuation of levodopa and coadministration with dopamine-blocking neuroleptics may attenuate the psychotic symptoms, but... -
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- Amino acid residues involved in agonist binding and its linking to channel gating, proximal to transmembrane domain of 5-HT3A receptor for halothane modulation
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Kim MK, Min KT, Koo BN
- KMID: 2031864
- Korean J Anesthesiol.
- 2009 Jan;56(1):66-73.
- doi: 10.4097/kjae.2009.56.1.66
BACKGROUND: The 5-hydroxytryptamine type 3 (5-HT3) receptor is a member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) and modulated by pharmacologic relevant concentrations of volatile anesthetics or n-alcohols... -
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- Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy
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Yang DG, Chang YS, Kim YS, Lee JG, Ahn KH, Park JM, Kim SK, Chung HC, Chang J, Ahn CM, Kim SK, Lee WY
- KMID: 2050145
- Tuberc Respir Dis.
- 1999 Jun;46(6):811-816.
- doi: 10.4046/trd.1999.46.6.811
BACKGROUND: Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin... -
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- Analgesic effects of palonosetron in the intravenous propofol injection
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Ryu HB, Kim SJ
- KMID: 2092428
- Korean J Anesthesiol.
- 2014 Feb;66(2):99-104.
- doi: 10.4097/kjae.2014.66.2.99
BACKGROUND: Propofol is a good induction agent, but it has the disadvantage of causing pain on intravenous injection. The incidence of propofol-induced pain is approximately 70%. Palonosetron is a novel... -
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- Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level
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Yoon MH, Bae HB, Choi JI, Kim SJ, Kim CM, Jeong ST, Kim KS, Jin WJ, Kim JP, Kim JS, Kim SY, Jeong CY
- KMID: 2277972
- Korean J Pain.
- 2005 Dec;18(2):113-117.
- doi: 10.3344/kjp.2005.18.2.113
BACKGROUND: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea... -
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- Seizure developed after palonosetron intravenous injection during recovery from general anesthesia: A case report
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Park PG, Shin HY, Kang H, Jung YH, Woo YC, Kim JY, Koo GH, Park SG, Baek CW
- KMID: 1780202
- Korean J Anesthesiol.
- 2012 Aug;63(2):173-176.
- doi: 10.4097/kjae.2012.63.2.173
Seizure associated with antiemetics is rare. We report seizure associated with a 5-HT3 receptor antagonist in a 38 years old female. The patient underwent ureterorenoscopic lithotripsy due to left upper... -
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- Modulatory Role of Adenylyl Cyclase and Protein Kinase A (PKA) in 5-hydroxytriptamine3 Induced Intracellular Calcium Increase in Parasympathetic Neurons of Rat Major Pelvic Ganglia
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Kim DR, Cha SK, Park KS, Song ES, Park YH, Song YS, Kong ID
- KMID: 2294142
- Korean J Urol.
- 2006 May;47(5):541-547.
- doi: 10.4111/kju.2006.47.5.541
PURPOSE: Serotonin has effects on the bladder contraction or urethral sphincter tone. Different subtypes of 5-hydroxytriptamine (5-HT) receptors appear to mediate the effects of serotonin on voiding. 5-HT1 and 5-HT2,... -
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- The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia
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Lim BG, Choi SS, Jeong YJ, Lim YJ, Kim YC, Park KU, Lee DK, Lee MK
- KMID: 2425272
- Korean J Anesthesiol.
- 2014 Dec;67(6):384-390.
- doi: 10.4097/kjae.2014.67.6.384
BACKGROUND: Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative NV, including intraoperative... -
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- Lamotrigine, an antiepileptic drug, inhibits 5-HT₃ receptor currents in NCB-20 neuroblastoma cells
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Kim KJ, Jeun SH, Sung KW
- KMID: 2371035
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):169-177.
- doi: 10.4196/kjpp.2017.21.2.169
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine... -
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- Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex
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Park SW, Jang HJ, Cho KH, Kim MJ, Yoon SH, Rhie DJ
- KMID: 2285442
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):65-70.
- doi: 10.4196/kjpp.2012.16.1.65
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP... -
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- A randomized, double-blind study to evaluate the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting after gynecological laparoscopic surgery
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Park SK, Cho EJ, Kang SH, Lee YJ, Kim DA
- KMID: 1798226
- Korean J Anesthesiol.
- 2013 Feb;64(2):133-137.
- doi: 10.4097/kjae.2013.64.2.133
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after anesthesia and surgery; 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have been considered as a first-line therapy. Ramosetron and palonosetron... -
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- Pharmacologic Agents for Chronic Diarrhea
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Lee KJ
- KMID: 2070745
- Intest Res.
- 2015 Oct;13(4):306-312.
- doi: 10.5217/ir.2015.13.4.306
Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type... -
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- Multicenter nonrandomized trial of ramosetron versus palonosetron in controlling chemotherapy-induced nausea and vomiting for colorectal cancer
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Kim JS, Kim JY, Lee SJ, Park DK, Namgung H, Kim CN, Choi WJ, Baek MJ
- KMID: 1804093
- Ann Surg Treat Res.
- 2014 Jul;87(1):9-13.
- doi: 10.4174/astr.2014.87.1.9
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) have a negative impact on patients' quality of life and frequently pointed to as a major factor for treatment abandonment. Serotonin (5-HT3) receptor antagonist... -
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- Role of 5-Hydroxytryptamine in Non-Adrenergic Non-cholinergic Relaxation of the Circcular Muscle from Rat Stomach Fundus
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Kim JH, Kang PJ, Kim CH, Cho SR, Lee IT, Park JH, Kim CH, Rhim BY
- KMID: 2084756
- Korean J Gastroenterol.
- 1997 Oct;30(4):433-444.
BACKGROUND AND AIMS: Gastrointestinal smooth muscle is innervated bv non-adrenergic, non-cholinergic (NANC) inhibitory neurons. These inhibitory enteric neurons play an important role in gastrointestinal motility, and are involved in receptive... -
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- Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats
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Yoo SH, Chung JH, Seo Y, Choi MK, Choi WK, Kim JB
- KMID: 2388836
- Anesth Pain Med.
- 2017 Jul;12(3):224-229.
- doi: 10.17085/apm.2017.12.3.224
BACKGROUND: Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant... -
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- Effect of Granisetron Plus Dexamethasone in the Prevention of Delayed Nausea and Vomiting
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Shim JW, Lee YS, Kim HU, Jung GW, Park YH, Chang SH, Whang JY, Jang JS, Lee JS
- KMID: 2059135
- J Korean Cancer Assoc.
- 1997 Aug;29(4):690-699.
BACKGROUND: Granisetron, a new 5-HT3 receptor antagonist, was reported as a highly effective antiemetics, especially in combination with dexamethasone, in the prevention of acute emesis induced by cisplatin. But there... -
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