Tuberc Respir Dis.  1999 Jun;46(6):811-816. 10.4046/trd.1999.46.6.811.

Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy

• Yang DG
• Chang YS
• Kim YS
• Lee JG
• Ahn KH
• Park JM
• Kim SK
• Chung HC
• Chang J
• Ahn CM
• Kim SK
• Lee WY

• KMID: 2050145
• DOI: http://doi.org/10.4046/trd.1999.46.6.811

Abstract

BACKGROUND: Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin.
METHODS
Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis.
RESULTS
Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002).
CONCLUSION
Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.

Keyword

Nausea and vomiting; Serotonin; Urinary 5-HIAA; Cisplatin chemotherapy

MeSH Terms

Cisplatin*
Drug Therapy*
Enterochromaffin Cells
Female
Humans
Hydroxyindoleacetic Acid
Male
Nausea
Ondansetron
Plasma
Receptors, Serotonin, 5-HT3
Serotonin
Vomiting
Cisplatin
Hydroxyindoleacetic Acid
Ondansetron
Receptors, Serotonin, 5-HT3
Serotonin