- Physiologic and Pathophysiologic Functions of Purinoceptors in Voiding Reflex
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Kim DK
- KMID: 2330962
- J Korean Continence Soc.
- 2008 Dec;12(2):93-98.
Purinergic neurotransmission has been regarded as major component of non-adrenergic, noncholinergic (NANC) contraction in detrusor smooth muscle. Although in normal human detrusor, this contraction seems to be small, the importance... -
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- Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors
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Chee HK, Oh SJ
- KMID: 2166514
- Genomics Inform.
- 2013 Dec;11(4):282-288.
- doi: 10.5808/GI.2013.11.4.282
The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors.... -
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- Na+ Homeostasis in the Inner Ear
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Kim SH, Kim SC
- KMID: 2037225
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Jul;53(7):399-407.
- doi: 10.3342/kjorl-hns.2010.53.7.399
Na+ homeostasis in the inner ear is important to maintain normal hearing and balance. Na+ transport in the inner ear is reported to be occurred in non-sensory epithelium of inner... -
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- Modulators of Ion Transport in Nasal Polyps: An in situ Measurement of Short-Circuit Current
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Lee JH, Rhee CS, Kim DW, Lee CH
- KMID: 1486057
- Clin Exp Otorhinolaryngol.
- 2008 Jun;1(2):75-79.
- doi: 10.3342/ceo.2008.1.2.75
OBJECTIVES: To examine possible modulators of the ion transport through the apical membrane of the nasal polyps. METHODS: The study was conducted using the freshly-excised nasal polyps from the patients... -
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- Existance of cholinergic and purinergic receptor on the detrusor muscle of rat urinary bladder
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Choi TS, Kwon OC, Ha JH, Lee KY, Kim WJ
- KMID: 2377369
- Yeungnam Univ J Med.
- 1991 Dec;8(2):138-149.
- doi: 10.12701/yujm.1991.8.2.138
This study was aimed at investigation of the stimulatory innervations on the rat urinary bladder. Detrusor muscle strips of 15 mm long were suspended in isolated muscle chambers containing 1... -
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- Membrane-Specific Expression of Functional Purinergic Receptors in Normal Human Nasal Epithelial Cells
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Kim CH, Kim SS, Yoo JB, Lee SY, Song MH, Lee JG, Yoon JH
- KMID: 1597341
- Korean J Otolaryngol-Head Neck Surg.
- 2005 May;48(5):606-614.
BACKGROUND AND OBJECTIVES: Extracellular purines and pyrimidines regulate various physiological responses via cell surface receptors known as purinoreceptors, and may exert autocrine or paracrine effects on ion transport, fluid transport,... -
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- Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine
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Park IK, Kim JH, Park CG, Kim MY, Parajuli S, Hong CS, Choi S, Jun JY
- KMID: 2458587
- Chonnam Med J.
- 2018 Jan;54(1):63-71.
- doi: 10.4068/cmj.2018.54.1.63
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles... -
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- Electrical Activity of the Bladder Is Attenuated by Intravesical Inhibition of P2X2/3 Receptors During Micturition in Female Rats
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Salazar BH, Hoffman KA, Zhang C, Kavanagh A, Zhang Y, Boone TB, Munoz A
- KMID: 2400893
- Int Neurourol J.
- 2017 Dec;21(4):259-269.
- doi: 10.5213/inj.1734998.499
PURPOSE: To simultaneously monitor electrical discharges in various bladder regions and the external urethral sphincter (EUS) during voiding contractions, and to assess the functional role of myogenic modulation of the... -
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- Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells
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Kim NH, Park KS, Sohn JH, Yeh BI, Ko CM, Kong ID
- KMID: 2389110
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):61-66.
P2Y receptors are metabotropic G-protein-coupled receptors, which are involved in many important biologic functions in the central nervous system including retina. Subtypes of P2Y receptors in retinal tissue vary according... -
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- Extracellular ATP stimulates Na+ and Cl- transport through the activation of multiple purinergic receptors on the apical and basolateral membranes in M-1 mouse cortical collecting duct cells
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Jung JS, Hwang SM, Lee RH, Kang SK, Woo JS, Kim YK
- KMID: 1606942
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):231-241.
The mammalian cortical collecting duct (CCD) plays a major role in regulating renal NaCl reabsorption, which is important in Na+ and Cl- homeostasis. The M-1 cell line, derived from the mouse cortical collecting... -
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- Effect of Uridine 5'-Triphosphate on Mucin Secretion in Human Middle Ear Epithelial Cells
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Choi JY, Lim JT, Yoon JH
- KMID: 2275992
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Feb;46(2):100-104.
BACKGROUND AND OBJECTIVES: Extracellular uridine 5'-triphosphate (UTP) regulates a variety of biological functions in the airway epithelium including chloride and fluid transport, mucociliary clearance, and mucin secretion via P2Y purinergic... -
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- Electrophysiological Effects of Purinergic Receptor Agonists on Atrial Muscle Fiber under Normal and Ischemic Conditions
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Kim JH, Ahn BH, Kang JC
- KMID: 2029390
- Korean Circ J.
- 1994 Aug;24(4):645-654.
- doi: 10.4070/kcj.1994.24.4.645
BACKGROUND: The electrophysiological effects of purinergic receptor agonists, adenosine triphosphate(ATP) and adenosine were examined using conventional microelectrode technique in rat atrial muscle fibers under superfused with a normal or a... -
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- Vascular Reactivity by Purinoceptor Activation in Rat Inferior Vena Cava
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Lee BS, Chung HS, Park KS, Kong ID, Jeong SW, Lee JW
- KMID: 2093759
- Korean Circ J.
- 2000 Sep;30(9):1156-1164.
- doi: 10.4070/kcj.2000.30.9.1156
BACKGROUND: Extracellular ATP, released from platelets and nerve endings, plays significant roles in the regulation of circulation. The effects of ATP depend on the location of the vessels and the... -
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- Expression of P2X3 and its colocalization with trpv1 in the human dental pulp
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Kim YK, Kim SK
- KMID: 2416529
- J Korean Acad Conserv Dent.
- 2007 Nov;32(6):514-521.
The purinoreceptor, P2X3 is a ligand-gated cation channel activated by extracellular ATP. It has been reported that ATP can be released during inflammation and tissue damage, which in turn may... -
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- Regulation of adenosine receptors in rat brain following chronic carbamazepine treatment
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Park KS, Yang WS, Kim KH
- KMID: 2285153
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):13-17.
Carbamazepine (CBZ), an anticonvulsant, has been reported to displace ligands at adenosine receptors. Several studies have demonstrated that as far as A-2 adenosine receptors is concerned, CBZ acts as an antagonist. However, the... -
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- Formation of Airway Mucus; Synthesis, Exocytosis and Dilution of Gel-Forming Mucins
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- KMID: 1969528
- Korean J Asthma Allergy Clin Immunol.
- 2012 Jun;32(2):73-80.
The lungs are highly defensive to environmental challenges thanks to the airway mucus layer, not only as a pool of antimicrobial and antioxidant contents but also as an important part... -
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- Participation of Central P2X7 Receptors in CFA-induced Inflammatory Pain in the Orofacial Area of Rats
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Yang KY, Kim MD, Ju JS, Kim MJ, Ahn DK
- KMID: 1703491
- Int J Oral Biol.
- 2014 Mar;39(1):49-56.
We investigated the role of central P2X receptors in inflammatory pain transmission in the orofacial area in rats. Experiments were carried out using male Sprague-Dawley rats weighing 230-280g. Complete Freund's... -
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- Effects of Uridine 5'-Triphosphate on the Vascular Tone of Rat Thoracic Aorta
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Park KS, Kong ID, Lee JW
- KMID: 2228958
- Korean Circ J.
- 1995 Feb;25(1):68-77.
- doi: 10.4070/kcj.1995.25.1.68
BACKGROUND: Uracil nucleotides are stored in platelets and all other cells, and are released into the extracellular space upon stimulation. They show various biological responses but their actions and mechanism... -
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- Extracellular Nucleotides Can Induce Chemokine (C-C motif) Ligand 2 Expression in Human Vascular Smooth Muscle Cells
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Kim JI, Kim HY, Kim SM, Lee SA, Son YH, Eo SK, Rhim BY, Kim K
- KMID: 2389106
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):31-36.
To understand the roles of purinergic receptors and cellular molecules below the receptors in the vascular inflammatory response, we determined if extracellular nucleotides up-regulated chemokine expression in vascular smooth muscle... -
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- Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment
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Kim SH, Lee HY, Jang YS
- KMID: 2150829
- Immune Netw.
- 2015 Feb;15(1):44-49.
- doi: 10.4110/in.2015.15.1.44
Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by... -
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