- Action Mechanisms of Hormone Binding to Nuclear Receptors: The Steroid Receptors: Molecular Mechanism of Action
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Choi HS
- KMID: 2199643
- J Korean Soc Endocrinol.
- 2000 Jun;15(3):388-401.
No Abstract Available. -
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- Action Mechanisms of Hormone Binding to Nuclear Receptors: Transcriptional Coregulators of the Nuclear Receptor Superfamily
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Lee JW, Cheong JH, Lee YC, Na SY, Lee SK
- KMID: 2199644
- J Korean Soc Endocrinol.
- 2000 Jun;15(3):402-412.
No Abstract Available. -
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- Metabolic Regulation of Nuclear Receptors
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Lee EK, Park YJ
- KMID: 1479201
- J Korean Endocr Soc.
- 2008 Jun;23(3):155-164.
- doi: 10.3803/jkes.2008.23.3.155
No abstract available. -
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- Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
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Lee JM
- KMID: 2368524
- Diabetes Metab J.
- 2017 Feb;41(1):10-19.
- doi: 10.4093/dmj.2017.41.1.10
Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have... -
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- Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
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Ferrell JM, Chiang JY
- KMID: 2454055
- Diabetes Metab J.
- 2019 Jun;43(3):257-272.
- doi: 10.4093/dmj.2019.0043
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are... -
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- Role of PXR and CAR in Cholestasis
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Suh JI
- KMID: 760626
- Korean J Hepatol.
- 2006 Mar;12(1):5-15.
Cholestatic liver diseases are characterized by impairments of bile flows and accumulations of biliary constituents such as bile acids and bilirubin. The changes of phase I and II metabolism and... -
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- Targeting the Peroxisome Proliferator-Activated Receptor-gamma to Counter the Inflammatory Milieu in Obesity
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Corzo C, Griffin PR
- KMID: 2174220
- Diabetes Metab J.
- 2013 Dec;37(6):395-403.
- doi: 10.4093/dmj.2013.37.6.395
Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in... -
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- Transporters and Nuclear Hormone Receptors associated with Cholesterol Metabolism in Gallbladder Epithelial Cells
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Lee J
- KMID: 2168079
- Hanyang Med Rev.
- 2007 Feb;27(1):20-28.
Bile is concentrated in the gallbladder, and is often supersaturated in terms of cholesterol concentration. Such high levels of cholesterol in gallbladder bile has clinical implications with respect to cholesterol... -
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- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
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Jeong JY, Jeoung NH, Park KG, Lee IK
- KMID: 2174390
- Diabetes Metab J.
- 2012 Oct;36(5):328-335.
- doi: 10.4093/dmj.2012.36.5.328
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it... -
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- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
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Kim MJ, Kim TH, Lee HH
- KMID: 2200980
- J Menopausal Med.
- 2015 Aug;21(2):79-81.
- doi: 10.6118/jmm.2015.21.2.79
Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active... -
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- NOD-Like Receptors in Infection, Immunity, and Diseases
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Kim YK, Shin JS, Nahm MH
- KMID: 2466346
- Yonsei Med J.
- 2016 Jan;57(1):5-14.
- doi: 10.3349/ymj.2016.57.1.5
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane receptors, NLRs are cytoplasmic receptors that play a crucial role in... -
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- Nuclear receptor regulation of stemness and stem cell differentiation
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Jeong Y, Mangelsdorf DJ
- KMID: 1119318
- Exp Mol Med.
- 2009 Aug;41(8):525-537.
- doi: 10.3858/emm.2009.41.8.091
Stem cells include a diverse number of toti-, pluri-, and multi-potent cells that play important roles in cellular genesis and differentiation, tissue development, and organogenesis. Genetic regulation involving various transcription... -
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- The Hairless Gene: A Putative Navigator of Hair Follicle Development
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Kim JK, Kim BK, Park JK, Choi JH, Kim Yoon S
- KMID: 1806234
- Genomics Inform.
- 2011 Sep;9(3):93-101.
The Hairless (HR) gene regulates the expression of several target genes as a transcriptional corepressor of nuclear receptors. The hair follicle (HF), a small independent organ of the skin, resides... -
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- Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease
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Kim SG, Kim BK, Kim K, Fang S
- KMID: 2373067
- Endocrinol Metab.
- 2016 Dec;31(4):500-504.
- doi: 10.3803/EnM.2016.31.4.500
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver... -
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- Implications for Farnesoid X Receptor Signaling on Bile Acid Metabolism as a Potential Therapeutic Strategy for Nonalcoholic Fatty Liver Disease
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Yang H, Park CY
- KMID: 2368794
- Korean J Obes.
- 2016 Dec;25(4):167-175.
- doi: 10.7570/kjo.2016.25.4.167
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both developed and developing countries and is an important risk factor for both hepatic and cardiometabolic mortality.... -
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- The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae
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Kang TJ, Chae GT
- KMID: 2150731
- Immune Netw.
- 2011 Dec;11(6):424-427.
- doi: 10.4110/in.2011.11.6.424
The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages... -
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- Effect of Retinoic Acid Derivatives Using Polyethylene Glycol(PEG), Polyvinyl Pyrrolidone(PVP) on Dermal Wound Healing
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Jung WS, Cha JH, Kim YW, Kim HJ
- KMID: 2203639
- J Korean Soc Plast Reconstr Surg.
- 2004 Sep;31(5):701-706.
Retinoids are compounds with pleiotropic functions, selectively targeting certain skin structures. They are vitamins which must be derived from diet because retinol(vitamin A) is not synthesized in the body, and... -
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- Functions and physiological roles of two types of estrogen receptors, ERalpha and ERbeta, identified by estrogen receptor knockout mouse
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Lee HR, Kim TH, Choi KC
- KMID: 1436696
- Lab Anim Res.
- 2012 Jun;28(2):71-76.
- doi: 10.5625/lar.2012.28.2.71
Estrogens, a class of steroid hormones, regulate the growth, development, and physiology of the human reproductive system. Estrogens also involve in the neuroendocrine, skeletal, adipogenesis, and cardiovascular systems. Estrogen signaling... -
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- Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor gamma Activity and on Glucose Uptake by Thiazolidinediones
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Lee KW, Ku YH, Kim M, Ahn BY, Chung SS, Park KS
- KMID: 2281640
- Diabetes Metab J.
- 2011 Aug;35(4):340-347.
- doi: 10.4093/dmj.2011.35.4.340
BACKGROUND: Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic beta-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor gamma (PPARgamma),... -
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