J Korean Endocr Soc.  2008 Jun;23(3):155-164. 10.3803/jkes.2008.23.3.155.

Metabolic Regulation of Nuclear Receptors

• Lee EK
• Park YJ

• KMID: 1479201
• DOI: http://doi.org/10.3803/jkes.2008.23.3.155

Abstract

No abstract available.

MeSH Terms

Receptors, Cytoplasmic and Nuclear
Receptors, Cytoplasmic and Nuclear

Figure

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  Fig. 1 Nuclear receptors as ligand-dependent transcription factors. A. the structure of the nuclear receptor : N-terminal activation function 1 (AF1), DNA binding, ligand binding, and C-terminal AF2 domains. B. Response elements in the nuclear receptor can be configured as either direct, inverted, or everted repeats of the hexad core sequence AGGTCA. The number of nucleotides between the two core elements (n) confers additional specificity. C. RXR heterodimers constitutively bind to response elements in the promoter regions of target genes.

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  Fig. 2 Metabolic regulation by thyroid hormone receptor (TR).

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  Fig. 3 Metabolic regulation by peroxisome proliferator-activated receptor (PPAR).

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  Fig. 4 Metabolic regulation by Liver X receptor (LXR).

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  Fig. 5 Metabolic regulation by farnesoid X receptor (FXR).

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  Fig. 6 Metabolic regulation by pregnane X receptor (PXR) and constitutive androstane receptor (CAR).

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  Fig. 7 Metabolic regulation by small heterodimer partner (SHP)

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