- RNA Regulation in Neurologic Disease and Cancer
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Darnell RB
- KMID: 2270800
- Cancer Res Treat.
- 2010 Sep;42(3):125-129.
The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response... -
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- RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment
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Hong S
- KMID: 2434281
- J Cancer Prev.
- 2017 Dec;22(4):203-210.
- doi: 10.15430/JCP.2017.22.4.203
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA... -
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- Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma
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Park BM, Lee JH, Kim SJ
- KMID: 2171666
- Ann Dermatol.
- 2014 Apr;26(2):256-258.
- doi: 10.5021/ad.2014.26.2.256
No abstract available. -
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- Alternative Polyadenylation in Human Diseases
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Chang JW, Yeh HS, Yong J
- KMID: 2406184
- Endocrinol Metab.
- 2017 Dec;32(4):413-421.
- doi: 10.3803/EnM.2017.32.4.413
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as... -
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- An Emerging Role for Circular RNAs in Osteoarthritis
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Yu CX, Sun S
- KMID: 2407857
- Yonsei Med J.
- 2018 May;59(3):349-355.
- doi: 10.3349/ymj.2018.59.3.349
Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form a covalently closed continuous loop without 5′ or 3′ polarities. With the... -
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- Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes
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He P, Tian N
- KMID: 2443606
- Korean J Physiol Pharmacol.
- 2019 May;23(3):181-189.
- doi: 10.4196/kjpp.2019.23.3.181
Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by... -
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- Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders
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Jeon SJ, Ryu JH, Bahn GH
- KMID: 2378800
- Biomol Ther.
- 2017 May;25(3):231-238.
- doi: 10.4062/biomolther.2016.042
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin... -
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- IMP3 Expression of the Cholangiocarcinoma in Cytology Specimen and Its Diagnostic Value
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Yang JW, Lee JS, Kim DC, Song DH, Ko GH, Lee JH
- KMID: 2277542
- Korean J Pathol.
- 2010 Dec;44(6):642-650.
BACKGROUND: Pathologists occasionally have difficulty in distinguishing cholangiocarcinoma from benign reactive cells on the biliary cytology. We estimated the diagnostic value of insulinlike growth factor II mRNA binding protein 3... -
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- Clinical Relevance for Serum Cold-Inducible RNA-Binding Protein Level in Alopecia Areata
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Shin JM, Ko JW, Kwon IS, Choi JW, Hong D, Lee JH, Seo YJ, Kim CD, Lee JH, Lee Y, Park KD
- KMID: 2451475
- Ann Dermatol.
- 2019 Aug;31(4):387-392.
- doi: 10.5021/ad.2019.31.4.387
BACKGROUND: Alopecia areata (AA), a chronic, relapsing hair-loss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond... -
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- Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
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Moon IS, Lee HJ, Park IS
- KMID: 1778833
- J Korean Med Sci.
- 2012 Oct;27(10):1241-1247.
- doi: 10.3346/jkms.2012.27.10.1241
Long-term synaptic plasticity requires addition of new proteins at the synaptic site. The local protein synthesis at subsynaptic sites confers advantageous mechanisms that would regulate the protein composition in local... -
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- LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer
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Yang H, Peng M, Li Y, Zhu R, Li X, Qian Z
- KMID: 2466034
- J Gastric Cancer.
- 2019 Dec;19(4):460-472.
- doi: 10.5230/jgc.2019.19.e43
PURPOSE: Long noncoding RNA 00703 (LINC00703) was found originating from a region downstream of Kruppel-like factor 6 (KLF6) gene, having 2 binding sites for miR-181a. Since KLF6 has been reported... -
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- Physical and Functional Interaction between 5-HT₆ Receptor and Nova-1
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Kim SH, Seo M, Hwang H, Moon DM, Son GH, Kim K, Rhim H
- KMID: 2439003
- Exp Neurobiol.
- 2019 Feb;28(1):17-29.
- doi: 10.5607/en.2019.28.1.17
5-HT₆ receptor (5-HT₆R) is implicated in cognitive dysfunction, mood disorder, psychosis, and eating disorders. However, despite its significant role in regulating the brain functions, regulation of 5-HT₆R at the molecular... -
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- High RNA-binding Motif Protein 3 Expression Is Associated with Improved Clinical Outcomes in Invasive Breast Cancer
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Kang SH, Cho J, Jeong H, Kwon SY
- KMID: 2421369
- J Breast Cancer.
- 2018 Sep;21(3):288-296.
- doi: 10.4048/jbc.2018.21.e34
PURPOSE: Expression of RNA-binding motif protein 3 (RBM3) is induced by hypoxia and hypothermia. Recently, high expression of RBM3 was reported to be associated with a good prognosis in colon... -
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- Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation
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Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG
- KMID: 1123466
- Exp Mol Med.
- 2009 Mar;41(3):189-200.
- doi: 10.3858/emm.2009.41.3.022
Protein phosphatase-1 (PP1) nuclear targeting subunit (PNUTS), also called PP1R10, p99, or CAT 53 was originally isolated as a mammalian nuclear PP1-binding protein. In this study, we performed yeast two-hybrid... -
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- Effect of Modulation of hnRNP L Levels on the Decay of bcl-2 mRNA in MCF-7 Cells
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Lim MH, Lee DH, Jung SE, Youn DY, Park CS, Lee JH
- KMID: 1457696
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):15-20.
- doi: 10.4196/kjpp.2010.14.1.15
It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L)... -
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- Developmental changes in hematopoietic stem cell properties
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Copley MR, Eaves CJ
- KMID: 2154274
- Exp Mol Med.
- 2013 Nov;45(11):e55.
Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate and maintain lifelong blood cell production. This functionality is achieved through their ability to undergo many divisions... -
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- Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues
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Sun Y, Zhang P, Zheng H, Dong L, Tan L, Song C, Qiu X, Liao Y, Meng C, Yu S, Ding C
- KMID: 2402689
- J Vet Sci.
- 2018 Jan;19(1):3-12.
- doi: 10.4142/jvs.2018.19.1.3
T-cell internal antigen-1 (TIA-1) has roles in regulating alternative pre-mRNA splicing, mRNA translation, and stress granule (SG) formation in human cells. As an evolutionarily conserved response to environmental stress, SGs... -
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- Clinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A
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Park CH, Lee JH, Lee NK, Lee YC, Lee SK
- KMID: 2412067
- Gut Liver.
- 2016 Sep;10(5):714-718.
- doi: 10.5009/gnl15283
BACKGROUND/AIMS: Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer... -
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- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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- Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice
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Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H
- KMID: 2410471
- Exp Neurobiol.
- 2018 Apr;27(2):103-111.
- doi: 10.5607/en.2018.27.2.103
A recent study reveals that missense mutations of EWSR1 are associated with neurodegenerative disorders such as amyotrophic lateral sclerosis, but the function of wild-type (WT) EWSR1 in the central nervous... -
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