- Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis
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Kim JW
- KMID: 1717321
- Korean J Hepatol.
- 2010 Sep;16(3):278-279.
- doi: 10.3350/kjhep.2010.16.3.278
No abstract available. -
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- Silencing of Long Non-Coding RNA MALAT1 Promotes Apoptosis of Glioma Cells
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Xiang J, Guo S, Jiang S, Xu Y, Li J, Li L, Xiang J
- KMID: 2373664
- J Korean Med Sci.
- 2016 May;31(5):688-694.
- doi: 10.3346/jkms.2016.31.5.688
The metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA) gene. However, little is known about the pathological role of lncRNA MALAT1 in glioma. In... -
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- Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma
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Tan XY, Chang S, Liu W, Tang HH
- KMID: 1774548
- Gut Liver.
- 2014 Mar;8(2):196-204.
BACKGROUND/AIMS: To evaluate the expression of CXC motif chemokine receptor 4 (CXCR4) in the tissues of patients with hilar cholangiocarcinoma (hilar-CCA) and to investigate the cell proliferation and frequency of... -
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- Prostaglandin E2 and Interleukin-1beta Reduce E-cadherin Expression by Enhancing Snail Expression in Gastric Cancer Cells
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Jee YS, Jang TJ, Jung KH
- KMID: 1782129
- J Korean Med Sci.
- 2012 Sep;27(9):987-992.
- doi: 10.3346/jkms.2012.27.9.987
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) on E-cadherin expression in SNU719... -
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- The Role of Focal Adhesion Kinase in the TGF-beta-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
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Hong S, Lee JB, Iizuka Y, Song YK, Seong GJ, Han SH
- KMID: 1120181
- Korean J Ophthalmol.
- 2012 Feb;26(1):45-48.
- doi: 10.3341/kjo.2012.26.1.45
PURPOSE: To investigate the role of focal adhesion kinase (FAK) in transforming growth factor (TGF)-beta-induced myofibroblast transdifferentiation of human Tenon's fibroblasts. METHODS: Primary cultured human Tenon's fibroblasts were exposed to TGF-beta1... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-kappaB Inhibition in Human Renal Proximal Tubular Epithelial Cells
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Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY
- KMID: 2069805
- J Korean Med Sci.
- 2014 Sep;29(Suppl 2):S139-S145.
- doi: 10.3346/jkms.2014.29.S2.S139
We evaluated the effect of cobalt chloride (CoCl2) on TNF-alpha and IFN-gamma-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2... -
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- Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation
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Jun JH, Choi JH, Bae SH, Oh SH, Kim GJ
- KMID: 2373138
- Clin Mol Hepatol.
- 2016 Sep;22(3):372-381.
- doi: 10.3350/cmh.2016.0032
BACKGROUND/AIMS: Chronic liver disease leads to liver fibrosis, and although the liver does have a certain regenerative capacity, this disease is associated with dysfunction of the liver vessels. C-reactive protein... -
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- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines
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Choi SH, Shin HW, Park JY, Yoo JY, Kim DY, Ro WS, Yun CO, Han KH
- KMID: 1717322
- Korean J Hepatol.
- 2010 Sep;16(3):280-287.
- doi: 10.3350/kjhep.2010.16.3.280
BACKGROUND/AIMS: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of... -
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- Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
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Chang W, Lee CY, Park JH, Park MS, Maeng LS, Yoon CS, Lee MY, Hwang KC, Chung YA
- KMID: 1482815
- J Vet Sci.
- 2013 Mar;14(1):69-76.
- doi: 10.4142/jvs.2013.14.1.69
The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of... -
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- Atg3-Mediated Lipidation of Atg8 Is Involved in Encystation of Acanthamoeba
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Moon EK, Chung DI, Hong Y, Kong HH
- KMID: 1090608
- Korean J Parasitol.
- 2011 Jun;49(2):103-108.
- doi: 10.3347/kjp.2011.49.2.103
Autophagy is a catabolic process involved in the degradation of a cell's own components for cell growth, development, homeostasis, and the recycling of cellular products. Autophagosome is an essential component... -
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- Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells
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Lee YS, Lee EK, Han IO, Park SH
- KMID: 1103587
- Exp Mol Med.
- 2008 Feb;40(1):43-51.
- doi: 10.3858/emm.2008.40.1.43
The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions.... -
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