- Small interfering RNA (siRNA): a hope for the loss-of-function studies in anesthesiology?
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Kim YH
- KMID: 1766494
- Korean J Anesthesiol.
- 2010 Dec;59(6):369-370.
- doi: 10.4097/kjae.2010.59.6.369
No abstract available. -
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- Tweety Homologs (TTYH) Freshly Join the Journey of Molecular Identification of the VRAC/VSOR Channel Pore
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Okada Y
- KMID: 2450208
- Exp Neurobiol.
- 2019 Apr;28(2):131-133.
- doi: 10.5607/en.2019.28.2.131
No abstract available. -
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- Functions of PIWI proteins in spermatogenesis
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Bak CW, Yoon TK, Choi Y
- KMID: 2045696
- Clin Exp Reprod Med.
- 2011 Jun;38(2):61-67.
- doi: 10.5653/cerm.2011.38.2.61
Recently, a significant understanding of the molecular mechanisms regulating spermatogenesis has been achieved utilizing small RNA molecules (small RNAs), including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs)... -
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- Current Prospects of RNA Interference-based Therapy in Organ Transplantation
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Kim JY
- KMID: 2202582
- J Korean Soc Transplant.
- 2015 Sep;29(3):101-108.
- doi: 10.4285/jkstn.2015.29.3.101
RNA interference (RNAi) is a normal cellular process in which small RNAs control gene expression. siRNAs introduced into cells suppress gene expression through their recognition and cleavage of cognate mRNAs... -
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- Small Interfering RNA–Mediated Suppression of Fas Modulate Apoptosis and Proliferation in Rat Intervertebral Disc Cells
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Park JB, Park C
- KMID: 2392649
- Asian Spine J.
- 2017 Oct;11(5):686-693.
- doi: 10.4184/asj.2017.11.5.686
STUDY DESIGN: In vitro cell culture model. PURPOSE: To investigate the effect of small interfering RNA (siRNA) on Fas expression, apoptosis, and proliferation in serum-deprived rat disc cells. OVERVIEW OF LITERATURE: Synthetic... -
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- The Blocking of TNF-alpha by RNA Interference and Its Influence on Synovial Fibroblast and Chondrocytes
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Kim HA
- KMID: 2334840
- J Korean Rheum Assoc.
- 2007 Dec;14(4):322-330.
OBJECTIVE: Small interfering RNA (siRNA) triggers RNA interference in mammalian somatic cells. TNF-alpha is a proinflammatory cytokine implicated in the pathogenesis of inflammatory arthritis including rheumatoid arthritis (RA). This study... -
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- siMacro: A Fast and Easy Data Processing Tool for Cell-Based Genomewide siRNA Screens
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Singh NK, Seo BY, Vidyasagar M, White MA, Kim HS
- KMID: 1806272
- Genomics Inform.
- 2013 Mar;11(1):55-57.
- doi: 10.5808/GI.2013.11.1.55
Growing numbers of studies employ cell line-based systematic short interfering RNA (siRNA) screens to study gene functions and to identify drug targets. As multiple sources of variations that are unique... -
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- Synthetic and Adenovirus Delivered Small Interference RNA Pools Targeting Conserved Regions of Foot-and-Mouth Disease Virus
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Kim SM, Lee KN, Ko YJ, Joo YS, Kim HS, Park JH
- KMID: 2168584
- J Bacteriol Virol.
- 2010 Dec;40(4):199-206.
- doi: 10.4167/jbv.2010.40.4.199
Foot-and-mouth disease (FMD) is an economically significant animal disease because of the speed of its transmission. Routine vaccination may not be effective for early protection in an outbreak situation. Small... -
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- Down-Regulation of Cellulose Synthase Inhibits the Formation of Endocysts in Acanthamoeba
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Moon EK, Hong Y, Chung DI, Goo YK, Kong HH
- KMID: 1792159
- Korean J Parasitol.
- 2014 Apr;52(2):131-135.
Acanthamoeba cysts are resistant to unfavorable physiological conditions and various disinfectants. Acanthamoeba cysts have 2 walls containing various sugar moieties, and in particular, one third of the inner wall is... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion
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Na KH, Choi JH, Kim CH, Kim KS, Kim GJ
- KMID: 1430078
- Clin Exp Reprod Med.
- 2013 Mar;40(1):12-22.
- doi: 10.5653/cerm.2013.40.1.12
OBJECTIVE: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. METHODS: NET and NE expression... -
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- The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats
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Ki KH, Park DY, Lee SH, Kim NY, Choi BM, Noh GJ
- KMID: 1766501
- Korean J Anesthesiol.
- 2010 Dec;59(6):403-410.
- doi: 10.4097/kjae.2010.59.6.403
BACKGROUND: Small interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions... -
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- The Effect of RNA Interference for TGF-beta1 Overexpression in Rat with Unilateral Ureteral Obstruction
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Kim HJ, Kim HC, Park KK
- KMID: 2307234
- Korean J Nephrol.
- 2005 Sep;24(5):739-748.
BACKGROUND: The progression of chronic renal diseases is an increasingly common condition, often leading to complete destruction of functional kidney tissue and dependency of affected individuals of life- long treatments... -
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- p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells
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Shrestha M, Park PH
- KMID: 2350505
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):487-498.
- doi: 10.4196/kjpp.2016.20.5.487
Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized... -
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- Expression and roles of NUPR1 in cholangiocarcinoma cells
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Kim KS, Jin DI, Yoon S, Baek SY, Kim BS, Oh SO
- KMID: 1447449
- Anat Cell Biol.
- 2012 Mar;45(1):17-25.
- doi: 10.5115/acb.2012.45.1.17
Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have... -
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- Effect of RNA Interference-Mediated Suppression of p75 on the Viability of Rat Notochordal Cells
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Park JB, Chang DG, Oh SY, Park EY
- KMID: 2362174
- Asian Spine J.
- 2016 Dec;10(6):985-992.
- doi: 10.4184/asj.2016.10.6.985
STUDY DESIGN: In vitro cell culture model. PURPOSE: To investigate the effects of RNA interference (RNAi) on p75 expression and viability of rat notochordal cells treated with serum deprivation. OVERVIEW OF LITERATURE:... -
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- Transcriptional Regulation of Hepatic Stellate Cell Activation by siRNA for TGF-beta1
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Oh HK, Kim KH, Keum YS, Cho CH, Park JB, Park KK
- KMID: 1472634
- Korean J Pathol.
- 2009 Dec;43(6):503-508.
- doi: 10.4132/KoreanJPathol.2009.43.6.503
BACKGROUND: The cytokine-induced activation of hepatic stellate cells (HSC) plays a major role in liver fibrosis. Quiescent HSCs undergo phenotypic transformation called "transdifferentiation" in response to viral, chemical or immune... -
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- Polymeric Gene Delivery for Diabetic Treatment
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Kim SW
- KMID: 2281637
- Diabetes Metab J.
- 2011 Aug;35(4):317-326.
- doi: 10.4093/dmj.2011.35.4.317
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene... -
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- The Role of CTGF in Osteosarcoma Progression
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Han I, Lee MR, Kim HS
- KMID: 1707758
- J Korean Bone Joint Tumor Soc.
- 2014 Jun;20(1):1-6.
- doi: 10.5292/jkbjts.2014.20.1.1
PURPOSE: To examine the expression of Connective Tissue Growth Factor (CTGF) in osteosarcoma and to evaluate its role in osteosarcoma invasion and proliferation. MATERIALS AND METHODS: The mRNA expression of CTGF... -
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- Effect of Small Hairpin RNA Molecules Targeting Angiotensin-converting Enzyme Gene in Spontaneously Hypertensive Rats
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Hong YM, Lee HR, Kim KC
- KMID: 2330959
- J Korean Soc Hypertens.
- 2012 Sep;18(3):105-116.
BACKGROUND: Interfering RNA (iRNA) represents a recent breakthrough in effective blocking of the target genes in mammalian cells. Angiotensin-converting enzyme (ACE) has been shown to play an important role in... -
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