- The Effect of a-Tocopherol in Puromycin Aminonucleoside Induced Nephropathy in Rats
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Seo HH, Jung TS, Lee ES, Shin SM, Park YH, Kim YJ
- KMID: 1543945
- J Korean Soc Pediatr Nephrol.
- 1999 May;3(1):35-41.
Hyalinizing trabecular adenoma is an uncommon benign thyroid tumor that is recently described in the literature. This tumor is easily confused with medullary carcinoma on surgical specimens and with papillay... -
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- Changes in Endothelin Receptor Type B and Neuronal Nitric Oxide Synthase in Puromycin Aminonucleoside-Induced Nephrotic Syndrome
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Bae EH, Kim SW
- KMID: 2285406
- Korean J Physiol Pharmacol.
- 2010 Aug;14(4):223-228.
- doi: 10.4196/kjpp.2010.14.4.223
The collecting duct endothelin (ET) system, which involves ET-1 and its two receptors, may play a role in the regulation of renal sodium in association with the nitric oxide synthase... -
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- Effect of Puromycin Aminonucleoside on Podocyte P-Cadherin
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Ha TS
- KMID: 2098914
- J Korean Soc Pediatr Nephrol.
- 2013 Oct;17(2):79-85.
PURPOSE: To test whether the expression of P-cadherin, a component of slit diaphragms between podocyte foot processes, would be altered by puromycin aminonucleoside (PAN) in a cultured podocyte in vitro. METHODS:... -
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- Ultrastructural Changes in Glomerular Anionic Sites in Puromycin Aminonucleoside Nephropathy
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Kim HC, Choi CO, Kim YH, Park KK
- KMID: 2037273
- Korean J Pathol.
- 2000 Jan;34(1):56-67.
An ultrastructural study was done on puromycin aminonucleoside (PAN) nephropathy which was induced in a group of Sprague-Dawley rats by a single intraperitoneally injected dose. To study the ultrastructural alteration... -
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- Morphological Changes in Glomerular Epithelial Cells and Basement Membranes in Puromycin Aminonucleoside Induced Nephropathy
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Choi CO, Kim HC, Park KK
- KMID: 1990094
- Korean J Nephrol.
- 1998 Nov;17(6):853-865.
Puromycin aminonucleoside (PAN) nephropathy was induced in a group of Sprague-Dawley rat by a single dose of intraperitoneal injection to study an ultrastructural alteration of glomerular anionic sites by stain... -
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- Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome
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Bae EH, Lee JU, Ma SK, Kim SW
- KMID: 2285364
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):1-7.
- doi: 10.4196/kjpp.2009.13.1.1
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and... -
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- The Effects of Selective Cyclooxygenase-2 Inhibition in Puromycin Aminonucleoside Nephropathy Rats
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Lee DW, Son JM, Kim JH, Jeong YS, Lee SB, Kwak IS
- KMID: 2307255
- Korean J Nephrol.
- 2004 Sep;23(5):714-720.
BACKGROUND: It is known that non-steroidal antiinflammatory drugs (NSAIDs) reduce the amount of proteinuria in nephrotic syndrome. It is based on the facts that the NSAIDs block the production of... -
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- Effect of Glomerular Cyclooxygenase-2 Overexpression on Podocyte Injury Induced by Puromycin in Mice
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Jo YI
- KMID: 2254037
- Korean J Nephrol.
- 2007 Mar;26(2):127-136.
PURPOSE: The aim of this study is to investigate the effect of glomerular cyclooxygenase-2 (COX-2) overexpression on podocyte injury by puromycin aminonucleoside (PAN) in nephrin-driven COX-2 transgenic mice. METHODS: We administrated... -
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- The Change of Podocyte beta-Catenin by Puromycin Aminonucleoside
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Choi JY, Ahn EM, Park HY, Shin JI, Ha TS
- KMID: 2196707
- J Korean Soc Pediatr Nephrol.
- 2011 Oct;15(2):138-145.
PURPOSE: To test whether the expression of beta-catenin, a component of podocyte as a filtration molecule, would be altered by puromycin aminonucleoside (PAN) in the cultured podocyte in vitro. METHODS: We... -
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- Puromycin aminonucleoside modulates p130Cas of podocytes
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Ha TS, Choi JY, Park HY
- KMID: 2140712
- Korean J Pediatr.
- 2012 Oct;55(10):371-376.
- doi: 10.3345/kjp.2012.55.10.371
PURPOSE: Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers... -
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- Effects of puromycin aminonucleoside on the cytoskeletal changes of glomerular epithelial cells
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Lee JH, Ha TS
- KMID: 1487159
- Korean J Pediatr.
- 2008 Jan;51(1):54-61.
- doi: 10.3345/kjp.2008.51.1.54
PURPOSE:This study was designed to clarify the mechanism of proteinuria in nephrotic syndrome patients by using puromycin aminonucleoside (PAN) nephrosis model. METHODS:Following administration of various concentrations of PAN and antioxidants we... -
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- Altered Expression of Renal AQP1, AQP2 and NHE3 in Puromycin Aminonucleoside Induced Nephrotic Syndrome: Intervention by Alpha-MSH Treatment
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Kwon TH, Kim KK
- KMID: 2079268
- Korean J Nephrol.
- 2003 Jan;22(1):10-23.
BACKGROUND: We examined whether puromycin aminonucleoside (PAN)-induced nephrotic syndrome (NS) is associated with altered renal handling of water and sodium along with changes of renal abundance of aquaporins (AQP1 and... -
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- Glomerular Hypertrophy and Sclerosis in Rats with Chronic Puromycin Aminonucleoside Nephropathy
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Kim SM, Jang HS, Hong IH, Ko CW, Koo JH, Kim YJ
- KMID: 2079075
- Korean J Nephrol.
- 2000 Mar;19(2):218-226.
PURPOSE: This experimental study was conducted to determine serial morphological changes of rat's kidney with chronic puromycin aminonucleoside (PAN) nephropathy. Special emphasis was given to the occurrence of glomerular hypertrophy... -
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- Effects of Dietary Salt Restriction on Puromycin Aminonucleoside Nephrosis: Preliminary Data
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Jo CH, Kim S, Park JS, Kim GH
- KMID: 2168385
- Electrolyte Blood Press.
- 2011 Dec;9(2):55-62.
- doi: 10.5049/EBP.2011.9.2.55
Proteinuria is a major promoter that induces tubulointerstitial injury in glomerulopathy. Dietary salt restriction may reduce proteinuria, although the mechanism is not clear. We investigated the effects of dietary salt... -
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- Renal Injury by Albumin Infusion in Puromycin Aminonucleoside Induced Nephrotic: Range Proteinuric Rats
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Sung SH, Lee SJ
- KMID: 1989889
- Korean J Nephrol.
- 2000 Nov;19(6):1033-1040.
PURPOSE: To examine the renal injury by albumin infusion, which has been widely used to correct severe nephrotic edema, in puromycin aminonucleoside(PAN) induced nephrotic-range proteinuric rats. MATERIALS AND METHODS: Sixty Sprague-Dawley... -
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- Expression of Nephrin in Puromycin Aminonucleoside Nephrosis in Rat
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Lee YK, Kwon TG, Kim DJ, Kim MK, Yoon SJ, Lee HH, Kim JA, Huh WS, Kim YG, Oh HY
- KMID: 2254432
- Korean J Nephrol.
- 2002 May;21(3):382-390.
BACKGROUND: Nephrin, a recently identified protein, could be a slit diaphragm component and it has been suggested to play a crucial role in maintaining the glomerular filtration barrier. It has... -
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- Puromycin aminonucleoside triggers apoptosis in podocytes by inducing endoplasmic reticulum stress
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Min SY, Ha DS, Ha TS
- KMID: 2447160
- Kidney Res Clin Pract.
- 2018 Sep;37(3):210-221.
- doi: 10.23876/j.krcp.2018.37.3.210
BACKGROUND: Puromycin aminonucleoside (PAN) is a known podocytotoxin. PAN-induced nephrosis is a widely used animal model for studying human idiopathic nephrotic syndrome. Abnormal protein accumulation associated with podocyte-specific endoplasmic reticulum... -
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- The Effect of Captopril on Urinary Protein Excretion and Anionic Sites on Glomerular Basement Membrane in Puromycin Aminonucleoside Nephrosis in Rats
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Park MS, Lee HS, Choi Y, Ko KW
- KMID: 2254834
- Korean J Nephrol.
- 1997 Jun;16(2):209-220.
Captopril, an orally active ACE inhibitor, has been known to attenuate the protein excretion in animal model such as puromycin-aminonucleoside(PAN)- induced nephrotic rats or partially nephrectomized rats and clinical study,... -
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- Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuries
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Lee SY, Choi JY, Jin DC, Kim J, Cha JH
- KMID: 2168886
- Anat Cell Biol.
- 2010 Jun;43(2):132-139.
- doi: 10.5115/acb.2010.43.2.132
Our previous research demonstrated that calponin-immunoreactivity was localized in myofibroblasts of the periglomerular region of human kidney specimens obtained at the time of transplantation from organ recipients. In the present... -
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- Effects of Celecoxib and Nordihydroguaiaretic Acid on Puromycin Aminonucleoside-Induced Nephrosis in the Rat
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Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Chung HC, Yang BY, Lee MY, Sol MY
- KMID: 1778160
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S183-S188.
- doi: 10.3346/jkms.2009.24.S1.S183
The selective cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX) inhibitors might inhibit prostaglandin synthesis and reduce proteinuria. The present study was designed to investigate the anti-proteinuric effects of nordihydroguaiaretic acid (NDGA) as... -
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