- Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?
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Cacciapuoti F
- KMID: 2385338
- J Rheum Dis.
- 2017 Jun;24(3):127-130.
- doi: 10.4078/jrd.2017.24.3.127
Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be... -
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- Comparison of DPP-4 Inhibitors
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Kim NH, Kim SG
- KMID: 2173918
- J Korean Diabetes.
- 2013 Sep;14(3):111-119.
- doi: 10.4093/jkd.2013.14.3.111
During past several years, a novel class of antihyperglycemic agents, dipeptidyl peptidase-4 (DPP-4) inhibitors, has become one of the most important options in the management of type 2 diabetes. These... -
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- Chronic Lymphocytic Leukemia-Era of Targeted Therapy
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Shin DY, Kim I
- KMID: 2267805
- Korean J Med.
- 2013 Aug;85(2):141-153.
Chronic lymphocytic leukemia (CLL) is a unique indolent B-cell leukemia which is rare in Korea. Many patients with early stage CLL do not require immediate treatment, while those with advanced... -
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- A Case of Patient with Eisenmenger Syndrome Admitted to Intensive Care Unit Due to Septic Shock Complicated with Newlydiagnosed Down Syndrome and Moyamoya Disease
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Lee SJ, Kang HW, Huh JW, Kim SW, Cho HW, Ryu YJ, Lee JH, Chang JH
- KMID: 2227842
- Korean J Crit Care Med.
- 2013 Aug;28(3):204-209.
- doi: 10.4266/kjccm.2013.28.3.204
Eisenmenger syndrome is a severe form of pulmonary arterial hypertension related to congenital cardiac defects. Many patients die at a young age from such complications. The treatment of primary pulmonary... -
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- Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease
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Park J, Song JH, Park DA, Lee JS, Lee SD, Oh YM
- KMID: 1793026
- J Korean Med Sci.
- 2013 Aug;28(8):1200-1206.
- doi: 10.3346/jkms.2013.28.8.1200
Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an... -
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- Comparison of the Population Pharmacokinetics and Safety Between Please Orally Soluble Film and VIAGRA(R) in Healthy Male Volunteers
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Hong T, Lee J, Jeon S, Paek J, Kim HI, Kwak SS, Park SJ, Han S, Yim DS
- KMID: 2334542
- J Korean Soc Clin Pharmacol Ther.
- 2013 Jun;21(1):26-33.
BACKGROUND: The objective of this study was to compare the pharmacokinetics and safety between newly developed sildenafil (Please Orally Soluble Film) and sildenafil citrate (VIAGRA(R)) after single oral administration in... -
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- Treatment Strategy for Non-Responders to PDE5 Inhibitors
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Park NC, Kim TN, Park HJ
- KMID: 2320852
- World J Mens Health.
- 2013 Apr;31(1):31-35.
Currently, phosphodiesterase type 5 (PDE5) inhibitors are the initial treatment option for erectile dysfunction. The reported efficacy of PDE5 inhibitors is about 70%, although it is significantly lower in difficult-to-treat... -
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- A Case of Inferior Rectus Muscle Enlargement after Taking Sildenafil Citrate
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Jung YH, Lee NY, Yim HB
- KMID: 2216679
- J Korean Ophthalmol Soc.
- 2013 Feb;54(2):382-386.
- doi: 10.3341/jkos.2013.54.2.382
PURPOSE: Sildenafil citrate was developed to treat angina, but was found to also inhibit PDE in the corpus callosum and is now widely used to treat impotence. We report a... -
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- Antipsychotic-Induced Sexual Dysfunction and Its Management
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Park YW, Kim Y, Lee JH
- KMID: 2320871
- World J Mens Health.
- 2012 Dec;30(3):153-159.
Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is... -
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- Persistent Pulmonary Hypertension of the Newborn in a Preterm Infant Exposed to Methotrexate During the Early Gestational Period
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Suh YE, Lee BS, Kim JJ, Won HS, Lim G, Choi YS, Kim EA, Kim KS
- KMID: 2280896
- Korean J Perinatol.
- 2012 Dec;23(4):292-297.
Methotrexate (MTX) is used in the reproductive aged females for the management of medical conditions such as ectopic pregnancy, autoimmune diseases and malignancies. Because of its antimetabolite effect, exposure to... -
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- Pulmonary Arterial Thrombosis in a Patient With an Atrial Septal Defect and Eisenmenger Syndrome
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Lee CW, Huang SS, Huang PH
- KMID: 2224978
- Korean Circ J.
- 2012 Nov;42(11):772-775.
- doi: 10.4070/kcj.2012.42.11.772
Pulmonary hypertension is characterized by elevated pulmonary arterial pressure and secondary right ventricular failure. A thromboembolic occlusion of the proximal or distal pulmonary vasculature results in chronic thromboembolic pulmonary hypertension.... -
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- Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study
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Lee SK, Kim JH, Kim JS, Jang Y, Kim J, Park YH, Chun KJ, Lee MY
- KMID: 1767173
- Korean J Anesthesiol.
- 2012 Oct;63(4):340-345.
- doi: 10.4097/kjae.2012.63.4.340
BACKGROUND: The activation of guanine nucleotide binding protein-coupled receptors, such as adenosine receptor (ADR) and opioid receptor (OPR), protects the heart against ischemia and reperfusion injury. We hypothesized that ADR... -
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- Acute Unilateral Vestibular Weakness Following Sildenafil Ingestion
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Kim KW, Lee JW, Jung JY, Suh MW
- KMID: 2277381
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2012 Aug;55(8):513-517.
- doi: 10.3342/kjorl-hns.2012.55.8.513
Sildenafil is an effective oral medication for male erectile disorder. Due to potential vasodilating effects, silenafil is known to have side effects such as headache, flushing, dyspepsia, and nasal congestion.... -
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- Treatment of a Chronic Gouty Ulcer on the Lateral Malleolus with Vacuum-Assisted Closure (VAC) Therapy
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Kim YH, Kim JS, Young KW, Lee HS, Hur JU, Lee KT
- KMID: 2223077
- J Rheum Dis.
- 2012 Aug;19(4):230-233.
- doi: 10.4078/jrd.2012.19.4.230
Gouty ulceration is a clinical manifestation of gout, which is a metabolic disease induced by disturbed purine metabolism. In general, protruded gout tophus and secondary infection made a gouty ulceration.... -
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- Hidden Questions on Methotrexate
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Lee SW
- KMID: 2223114
- J Rheum Dis.
- 2012 Feb;19(1):11-18.
- doi: 10.4078/jrd.2012.19.1.11
Since the 1950's, methotrexatehas been the most widely used for the treatment of rheumatoid arthritis among various disease-modifying anti-rheumatic drugs (DMARDs). In this review, several hidden questions on methotrexate were... -
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- Analysis of Prescriptions of Alpha-Blockers and Phosphodiesterase 5 Inhibitors from the Urology Department and Other Departments
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Kang DH, Lee JY, Chung JH, Cho HJ, Cho JM, Moon HS, Kim YT, Yoo TK, Choi HY, Park HY, Lee SW
- KMID: 2232823
- Int Neurourol J.
- 2011 Dec;15(4):216-221.
PURPOSE: We analyzed the prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors (PDE5Is) in the urology department as well as in other departments of the general hospital. METHODS: We investigated the frequency... -
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- Bilateral Simultaneous Acute Angle Closure Glaucoma Following Sexual Intercourse Aided by Sildenafil Citrate
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Lee WJ, Seong M
- KMID: 2337989
- J Korean Ophthalmol Soc.
- 2011 Sep;52(9):1123-1127.
PURPOSE: The authors of the present study report a case of bilateral simultaneous acute angle closure glaucoma following sildenafil citrate-aided sexual intercourse. CASE SUMMARY: A 63-year-old man visited the emergency department... -
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- Interstitial Lung Disease
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Chung MP
- KMID: 2319549
- Tuberc Respir Dis.
- 2011 Sep;71(3):163-171.
Recently published articles on interstitial lung disease (ILD) have focused on the accurate diagnosis of idiopathic pulmonary fibrosis (IPF), serum biomarkers, acute exacerbation of IPF, the prognostic factors of ILD... -
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- Role of Phosphodiesterase Type 5 Inhibitor on Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms
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Kim SD, Park JK
- KMID: 2226462
- Korean J Androl.
- 2011 Aug;29(2):91-100.
- doi: 10.5534/kja.2011.29.2.91
There is strong evidence from multiple epidemiological studies that benign prostate hyperplasia (BPH) induced lower urinary tract symptoms (LUTS) are correlated with erectile dysfunction (ED). Although a direct causal relationship... -
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- Oral Sildenafil in Persistent Pulmonary Hypertension of the Newborn
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Son SB, Kim KA, Yun SY, Ko SY, Lee YK, Shin SM
- KMID: 2188477
- J Korean Soc Neonatol.
- 2011 May;18(1):124-129.
- doi: 10.5385/jksn.2011.18.1.124
PURPOSE: To evaluate the effect of oral sildenafil therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN) METHODS: We conducted a retrospective review of 32 neonates > or =35... -
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