World J Mens Health.  2012 Dec;30(3):153-159.

Antipsychotic-Induced Sexual Dysfunction and Its Management

• Park YW
• Kim Y
• Lee JH

Abstract

Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole. With regard to treatment in patients suffering from sexual dysfunction, sildenafil was associated with significantly more erections sufficient for penetration as compared to a placebo. Subsequent studies are needed in order to provide physicians with a better understanding of this problem, thereby leading toward efficacious and safe solutions.

Keyword

Sexual dysfunction; Antipsychotic agents; Management

MeSH Terms

Antipsychotic Agents
Benzodiazepines
Clozapine
Compliance
Dibenzothiazepines
Haloperidol
Humans
Hyperprolactinemia
Piperazines
Purines
Quinolones
Receptors, Dopamine D2
Risperidone
Stress, Psychological
Sulfones
Sulpiride
Thiazoles
Aripiprazole
Quetiapine Fumarate
Sildenafil Citrate
Antipsychotic Agents
Benzodiazepines
Clozapine
Dibenzothiazepines
Haloperidol
Piperazines
Purines
Quinolones
Receptors, Dopamine D2
Risperidone
Sulfones
Sulpiride
Thiazoles