- Withaferin A-Caused Production of Intracellular Reactive Oxygen Species Modulates Apoptosis via PI3K/Akt and JNKinase in Rabbit Articular Chondrocytes
-
Yu SM, Kim SJ
- KMID: 2129597
- J Korean Med Sci.
- 2014 Aug;29(8):1042-1053.
- doi: 10.3346/jkms.2014.29.8.1042
Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Antioxidant on Reduction of Hindlimb Muscle Atrophy Induced by Cisplatin in Rats
-
Kim JI, Choe MA
- KMID: 1791866
- J Korean Acad Nurs.
- 2014 Aug;44(4):371-380.
- doi: 10.4040/jkan.2014.44.4.371
PURPOSE: The purpose of this study was to examine the effects of Cu/Zn SOD on reduction of hindlimb muscular atrophy induced by cisplatin in rats. METHODS: Forty-two rats were assigned to... -
- CITED
-
- Close
- SHARE
-
- Close
- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
-
Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
- CITED
-
- Close
- SHARE
-
- Close
- Overexpression of Human Arginine Decarboxylase Rescues Human Mesenchymal Stem Cells against H2O2 Toxicity through Cell Survival Protein Activation
-
Seo SK, Yang W, Park YM, Lee WT, Park KA, Lee JE
- KMID: 1786932
- J Korean Med Sci.
- 2013 Mar;28(3):366-373.
- doi: 10.3346/jkms.2013.28.3.366
In this study, we explored the potentiality of human arginine decarboxylase (ADC) to enhance the survival of mesenchymal stem cells (MSCs) against unfavorable milieu of host tissues as the low... -
- CITED
-
- Close
- SHARE
-
- Close
- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
-
Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
- CITED
-
- Close
- SHARE
-
- Close
- Early Sustained Injections of Erythropoietin Improve Angiogenesis and Restoration of Perfusion in the Ischemic Mouse Hindlimb
-
Ahn S, Min SK, Min SI, Suh JH, Kim SJ, Ha J
- KMID: 1782142
- J Korean Med Sci.
- 2012 Sep;27(9):1073-1078.
- doi: 10.3346/jkms.2012.27.9.1073
This study was conducted to investigate the effects of erythropoietin (Epo) on both acute and chronic limb ischemia (ALI and CLI) and to evaluate the differences in mechanisms according to... -
- CITED
-
- Close
- SHARE
-
- Close
- Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3beta signaling pathway
-
Jun HO, Kim DH, Lee SW, Lee HS, Seo JH, Kim JH, Kim JH, Yu YS, Min BH, Kim KW
- KMID: 991623
- Exp Mol Med.
- 2011 Jan;43(1):53-61.
- doi: 10.3858/emm.2011.43.1.006
Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium. Here, we report that clusterin... -
- CITED
-
- Close
- SHARE
-
- Close
- Haloperidol and clozapine differentially regulate signals pstream of glycogen synthase kinase 3 in the rat frontal cortex
-
Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, Kang UG, Juhnn YS, Kim YS
- KMID: 1047086
- Exp Mol Med.
- 2007 Jun;39(3):353-360.
Glycogen synthase kinase 3 (GSK3) was recently suggested to be a potential target of psychotropics used in psychiatric illnesses such as schizophrenia and bipolar disorder. Relevant studies have found that... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin
-
Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J, Kim TY
- KMID: 2155352
- Exp Mol Med.
- 2014 Mar;46(3):e87.
- doi: 10.1038/emm.2013.157
Inflammation is a part of the complex biological responses of a tissue to injury that protect the organ by removing injurious stimuli and initiating the healing process, and is considered... -
- CITED
-
- Close
- SHARE
-
- Close
- Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation
-
Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH
- KMID: 1047088
- Exp Mol Med.
- 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effects of Family History of Colorectal Cancer on the Development of Colorectal Adenoma
-
Choi MY, Kim BG, Kim JW, Lee KL, Jeong JB, Lee JK, Jung YJ, Kim W, Ahn DW, Kim YH, Joo SK, Chang MS, Kwon HJ
- KMID: 1718464
- Korean J Gastroenterol.
- 2012 Jul;60(1):36-41.
- doi: 10.4166/kjg.2012.60.1.36
BACKGROUND/AIMS: Early detection of polyp is important for the prevention of colorectal cancer (CRC). There have been few studies to investigate the relationship between colorectal adenoma and family history of... -
- CITED
-
- Close
- SHARE
-
- Close
- Combined treatment with silibinin and either sorafenib or gefitinib enhances their growth-inhibiting effects in hepatocellular carcinoma cells
-
Gu HR, Park SC, Choi SJ, Lee JC, Kim YC, Han CJ, Kim J, Yang KY, Kim YJ, Noh GY, No SH, Jeong JH
- KMID: 2155291
- Clin Mol Hepatol.
- 2015 Mar;21(1):49-59.
- doi: 10.3350/cmh.2015.21.1.49
BACKGROUND/AIMS: Silibinin, the main component of silymarin, is used as a hepatoprotectant and exhibits anticancer effects against various cancer cells. This study evaluated the effects of a combination of silibinin... -
- CITED
-
- Close
- SHARE
-
- Close
- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells
-
Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston R, Chung YH
- KMID: 1097265
- Exp Mol Med.
- 2011 Feb;43(2):82-90.
- doi: 10.3858/emm.2011.43.2.010
It is not yet understood how the enhanced expression of pancreatic adenocarcinoma up-regulated factor (PAUF; a novel oncogene identified in our recent studies), contributes to the oncogenesis of pancreatic cells.... -
- CITED
-
- Close
- SHARE
-
- Close
- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
-
Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
- CITED
-
- Close
- SHARE
-
- Close
- Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
-
Kim D, Kim SJ, Kang SS, Jin EJ
- KMID: 756209
- Exp Mol Med.
- 2009 Sep;41(9):656-664.
- doi: 10.3858/emm.2009.41.9.072
Curcumin is a well known natural polyphenol product isolated from the rhizome of the plant Curcuma longa, anti-inflammatory agent for arthritis by inhibiting synthesis of inflammatory prostaglandins. However, the mechanisms... -
- CITED
-
- Close
- SHARE
-
- Close
- Bilirubin Activates Transcription of HIF-1alpha in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content
-
Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ
- KMID: 2069806
- J Korean Med Sci.
- 2014 Sep;29(Suppl 2):S146-S154.
- doi: 10.3346/jkms.2014.29.S2.S146
The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which... -
- CITED
-
- Close
- SHARE
-
- Close
- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
-
Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells
-
Nguyen TL, Kim CK, Cho JH, Lee KH, Ahn JY
- KMID: 1104385
- Exp Mol Med.
- 2010 Aug;42(8):583-595.
- doi: 10.3858/emm.2010.42.8.060
Neurotrophins protect neurons against excitotoxicity; however the signaling mechanisms for this protection remain to be fully elucidated. Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway... -
- CITED
-
- Close
- SHARE
-
- Close
- Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1
-
Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH
- KMID: 1123464
- Exp Mol Med.
- 2009 Mar;41(3):171-179.
- doi: 10.3858/emm.2009.41.3.020
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in... -
- CITED
-
- Close
- SHARE
-
- Close
- Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle
-
Oh YS, Kim HJ, Ryu SJ, Cho KA, Park YS, Park H, Kim M, Kim CK, Park SC
- KMID: 1047091
- Exp Mol Med.
- 2007 Jun;39(3):395-401.
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in... -
- CITED
-
- Close
- SHARE
-
- Close
