- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Molecules and their functions in autophagy
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Pyo JO, Nah J, Jung YK
- KMID: 1120125
- Exp Mol Med.
- 2012 Feb;44(2):73-80.
- doi: 10.3858/emm.2012.44.2.029
Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved... -
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- Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
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Lee YK, Hur W, Lee SW, Hong SW, Kim SW, Choi JE, Yoon SK
- KMID: 2155342
- Exp Mol Med.
- 2014 Feb;46(2):e77.
- doi: 10.1038/emm.2013.151
14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study,... -
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- Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled
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Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH
- KMID: 1009391
- Exp Mol Med.
- 2009 Oct;41(10):695-706.
- doi: 10.3858/emm.2009.41.10.076
Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and... -
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- Brain site-specific proteome changes in aging-related dementia
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Manavalan , Mishra M, Feng L, Sze SK, Akatsu H, Heese K
- KMID: 2154258
- Exp Mol Med.
- 2013 Sep;45(9):e39.
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer's disease (AD)). Our study... -
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- Developmental changes in hematopoietic stem cell properties
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Copley MR, Eaves CJ
- KMID: 2154274
- Exp Mol Med.
- 2013 Nov;45(11):e55.
Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate and maintain lifelong blood cell production. This functionality is achieved through their ability to undergo many divisions... -
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- Codon optimization of the rabbit hemorrhagic disease virus (RHDV) capsid gene leads to increased gene expression in Spodoptera frugiperda 9 (Sf9) cells
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Gao J, Meng C, Chen Z, Li C, Liu G
- KMID: 1712311
- J Vet Sci.
- 2013 Dec;14(4):441-447.
- doi: 10.4142/jvs.2013.14.4.441
Rabbit hemorrhagic disease (RHD) is contagious and highly lethal. Commercial vaccines against RHD are produced from the livers of experimentally infected rabbits. Although several groups have reported that recombinant subunit... -
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- C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
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Kim JW, Ahn YH
- KMID: 755211
- Exp Mol Med.
- 2002 Nov;34(5):379-384.
The expression of the GLUT2 glucose transporter gene in liver is suppressed in cultured hepatoma cell lines and primary cultured hepatocytes. Earlier report showed that CCAAT/enhancer binding protein (C/EBP) regulates... -
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- Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-kappaB/Caspase-1 pathway in Sprague-Dawley Rats
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Jia H, Chen W, Yu X, Wu X, Li S, Liu H, Liao J, Liu W, Mi M, Liu L, Cheng D
- KMID: 1705566
- J Vet Sci.
- 2013 Sep;14(3):345-353.
- doi: 10.4142/jvs.2013.14.3.345
The effects of black rice anthocyanidins (BRACs) on retinal damage induced by photochemical stress are not well known. In the present study, Sprague-Dawley rats were fed AIN-93M for 1 week,... -
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- Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
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Song JY, Bae HS, Koo DH, Lee JK, Jung HH, Lee KW, Lee NW
- KMID: 2157970
- J Korean Med Sci.
- 2012 Dec;27(12):1479-1485.
- doi: 10.3346/jkms.2012.27.12.1479
Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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- Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change
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Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC
- KMID: 1778028
- J Korean Med Sci.
- 2010 Mar;25(3):353-360.
- doi: 10.3346/jkms.2010.25.3.353
Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated.... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Development of a novel enzyme-linked immunosorbent assay to detect anti-IgG against swine hepatitis E virus
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Lee WJ, Shin MK, Cha SB, Yoo HS
- KMID: 1712314
- J Vet Sci.
- 2013 Dec;14(4):467-472.
- doi: 10.4142/jvs.2013.14.4.467
Swine hepatitis E virus (HEV) is widespread throughout pigs in both developing and industrialized countries. This virus is an important zoonotic agent and a public concern worldwide. Infected pigs are... -
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- Identification of a putative transactivation domain in human Nanog
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Oh JH, Do HJ, Yang HM, Moon SY, Cha KY, Chung HM, Kim JH
- KMID: 1056238
- Exp Mol Med.
- 2005 Jun;37(3):250-254.
Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells. It has been reported that murine Nanog has two... -
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- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus
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Muleke CI, Ruofeng Y, Lixin X, Yanming S, Xiangrui L
- KMID: 1089909
- J Vet Sci.
- 2006 Sep;7(3):249-255.
- doi: 10.4142/jvs.2006.7.3.249
Because of the complexity of the cathepsin B-like (CBL) family, an information on the biological and biochemical characteristics of individual CBL genes is lacking. In this study, we investigated the... -
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- Monitoring transfected cells without selection agents by using the dual-cassette expression EGFP vectors
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Kang SG, Lee EK, Schaus S, Henderson
- KMID: 938883
- Exp Mol Med.
- 2001 Sep;33(3):174-178.
Conventional methods of selecting gene transfected cells by toxic agents may yield ambiguous results. It is difficult to determine whether cell death is due to selection agents or gene transfection,... -
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- 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells
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Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS
- KMID: 1103318
- Exp Mol Med.
- 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of... -
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- Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia
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Hamasaki N, Kuma H, Tsuda H
- KMID: 1781292
- Ann Lab Med.
- 2013 Jan;33(1):8-13.
- doi: 10.3343/alm.2013.33.1.8
Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the... -
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