- Molecular Basis of Drug Resistance: Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Anaplastic Lymphoma Kinase Inhibitors
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Yang SH
- KMID: 2320467
- Tuberc Respir Dis.
- 2013 Nov;75(5):188-198.
Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary... -
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- Regulation of Protein Kinase in KCl-induced Contraction of Cat Gastric Smooth Muscle
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Kim MS, Jo YH, Yoon SH, Hahn SJ, Sim SS, Shim HS, Rhie DJ, Kim SR
- KMID: 2304693
- Korean J Gastroenterol.
- 1998 Sep;32(3):290-297.
BACKGROUND AND AIMS: Smooth muscle contraction and relaxation are suggested to be modulated by intracellular Ca2+, protein kinases and tyrosine kinases. To investigate whether protein kinases are invelved in the... -
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- RET: A Multi-Faceted Gene in Human Cancer
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Santoro M, Carlomagno F, Melillo RM
- KMID: 2282399
- Endocrinol Metab.
- 2012 Sep;27(3):173-179.
- doi: 10.3803/EnM.2012.27.3.173
REarranged during Transfection (RET) gene encodes a receptor tyrosine kinase and it was initially discovered as an in vitro transforming gene. For many years, RET has been involved in papillary... -
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- The Efficacy and Safety of a Tofacitinib in the Treatment of Active Ulcerative Colitis
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Seo GS
- KMID: 1718070
- Korean J Gastroenterol.
- 2013 Jun;61(6):354-355.
- doi: 10.4166/kjg.2013.61.6.354
No abstract available. -
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- Effects of Ca2+ Antagonists and Protein Kinase Inhibitors on Ethanol-Induced Contraction of Cat Gastric Smooth Muscle
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Sim SS, Choi JC, Kim MS, Kim CJ, Jo YH
- KMID: 2240323
- Korean J Gastroenterol.
- 2000 May;35(5):539-545.
BACKGROUND/AIMS: The mechanism of ethanol in contraction of gastric smooth muscle still remains unclear. To investigate underlying mechanism of ethanol in tonic contraction, we measured isometric contractions of cat gastric smooth muscle using... -
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- Skin-Related Toxicity of Tyrosine Kinase Inhibitor in Thyroid Cancer
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Lim DJ
- KMID: 2448976
- Int J Thyroidol.
- 2018 Nov;11(2):82-87.
- doi: 10.11106/ijt.2018.11.2.82
Skin-related toxicity is one of the most important adverse events from multi-target tyrosine kinase inhibitor (MTKI) to treat radioiodine refractory thyroid cancer. As hand foot skin reaction can limit quality... -
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- Regulation of Helicobacter pylori-induced Interleukin-8 Production by Gastric Epithelial Cells in vitro
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Lee YC, Kim WH, Lee HY, Moon YM, Kang JK, Park IS
- KMID: 2240437
- Korean J Gastroenterol.
- 1999 May;33(5):601-614.
BACKGROUND/AIMS: Production of interleukin-8 (IL-8) by gastric epithelial cells may play an impor tant role in H. pylori-induced mucosal injury. The aim of this study was to evaluate physico-chemica factors... -
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- Regulation of the contraction induced by emptying of intracellular Ca2+ stores in cat gastric smooth muscle
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Baek HJ, Sim SS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS
- KMID: 1982597
- Korean J Physiol Pharmacol.
- 2000 Apr;4(2):113-120.
To investigate the mechanism of smooth muscle contraction induced by emptying of intracellular Ca2+ stores, we measured isometric contraction and 45Ca2+ influx. CaCl2 increased Ca2+ store emptying- induced contraction in dose-dependent manner, but... -
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- p21-Activated Kinases (PAKs) as a Therapeutic Target
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Koo BS
- KMID: 2277281
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Dec;54(12):813-818.
- doi: 10.3342/kjorl-hns.2011.54.12.813
p21-activated kinases (PAKs) are a family of serine/threonine protein kinases comprised of six isoform (PAK1-6), all of which are direct targets of the small GTPases Rac and Cdc42. PAKs have... -
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- Development of Tyrosine Kinase Inhibitor in Chronic Myeloid Leukemia
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Kim H
- KMID: 2168203
- Hanyang Med Rev.
- 2012 May;32(2):103-111.
- doi: 10.7599/hmr.2012.32.2.103
Chronic myeloid leukemia (CML) is a malignant disease induced by the oncogenic signal of the BCRABL transcript resulting from the translocation between chromosome 9 and 22, t (9:22). This genetic... -
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- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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- Current Status of Molecular Targeted Therapies in Hepatocellular Carcinoma
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Suh SJ, Yim HJ
- KMID: 1501636
- Korean J Gastroenterol.
- 2013 Mar;61(3):136-146.
- doi: 10.4166/kjg.2013.61.3.136
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in Korea. Curative treatment is only possible when the disease is diagnosed at the early stage. The prognosis... -
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- Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes
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Kwak YG, Chae SW
- KMID: 2285223
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,... -
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- Persistent suboptimal molecular response in a patient with chronic myelogenous leukemia and Klinefelter syndrome
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Chakraborty R, Mukkamalla SKR, Singam K, Calderon N
- KMID: 2070143
- Korean J Intern Med.
- 2014 Nov;29(6):827-829.
- doi: 10.3904/kjim.2014.29.6.827
No abstract available. -
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- Telomerase Activity is Constitutively Expressed in the Murine CD8+ T Cells and Controlled Transcriptionally and Post-Translationally
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Kim S, Kim M, Kim K
- KMID: 2167978
- Immune Netw.
- 2004 Sep;4(3):166-175.
- doi: 10.4110/in.2004.4.3.166
BACKGROUND: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of... -
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- Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase
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Ha TS, Park HY, Seong SB, Ahn HY
- KMID: 2363691
- J Korean Med Sci.
- 2016 Apr;31(4):535-541.
- doi: 10.3346/jkms.2016.31.4.535
Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the... -
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- Rapid Sequential Gain of ABL1 Kinase Domain Mutations with a Complex Karyotype in the Progression of Chronic Myelogenous Leukemia
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Chung Y, Eom HS, Lee H, Park S, Shim H, Cho EH, Kong SY
- KMID: 1791958
- Ann Lab Med.
- 2014 Sep;34(5):399-401.
- doi: 10.3343/alm.2014.34.5.399
No abstract available. -
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- Molecular targeted therapy for advanced gastric cancer
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Kim JG
- KMID: 1501767
- Korean J Intern Med.
- 2013 Mar;28(2):149-155.
- doi: 10.3904/kjim.2013.28.2.149
Although medical treatment has been shown to improve quality of life and prolong survival, no significant progress has been made in the treatment of advanced gastric cancer (AGC) within the... -
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- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
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Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
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- Involvement of Src Family Tyrosine Kinase in Apoptosis of Human Neutrophils Induced by Protozoan Parasite Entamoeba histolytica
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Sim S, Yu JR, Lee YA, Shin MH
- KMID: 1104693
- Korean J Parasitol.
- 2010 Dec;48(4):285-290.
- doi: 10.3347/kjp.2010.48.4.285
Tyrosine kinases are one of the most important regulators for intracellular signal transduction related to inflammatory responses. However, there are no reports describing the effects of tyrosine kinases on neutrophil... -
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